Zobrazeno 1 - 10
of 98
pro vyhledávání: '"M. Kyle Hadden"'
Autor:
Radha Charan Dash, Jiachen Wen, Angela M. Zaino, Shana R. Morel, Lianne Q. Chau, Robert J. Wechsler-Reya, M. Kyle Hadden
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 265-276 (2021)
The glioma-associated family of transcription factors (GLI) have emerged as a promising therapeutic target for a variety of human cancers. In particular, GLI1 plays a central role as a transcriptional regulator for multiple oncogenic signaling pathwa
Externí odkaz:
https://doaj.org/article/34eced58f47c49659557437a8bf7db95
Autor:
Chang Huang, Denzil Bernard, Jiaqi Zhu, Radha Charan Dash, Alexander Chu, Alec Knupp, Anna Hakey, M. Kyle Hadden, Antonio Garmendia, Young Tang
Publikováno v:
Virology Journal, Vol 17, Iss 1, Pp 1-11 (2020)
Abstract Background Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating diseases affecting the pork industry globally. PRRS is caused by PRRS virus (PRRSV). Currently there are no effective treatments agai
Externí odkaz:
https://doaj.org/article/5f2b1d07a8464d7e92b4f6890e5b49e4
Autor:
Kanayo E. Ikeh, Erica N. Lamkin, Andrew Crompton, Jamie Deutsch, Kira J. Fisher, Mark Gray, David J. Argyle, Won Y. Lim, Dmitry M. Korzhnev, M. Kyle Hadden, Jiyong Hong, Pei Zhou, Nimrat Chatterjee
Publikováno v:
Cancers, Vol 13, Iss 21, p 5290 (2021)
Cancer therapy resistance is a persistent clinical challenge. Recently, inhibition of the mutagenic translesion synthesis (TLS) protein REV1 was shown to enhance tumor cell response to chemotherapy by triggering senescence hallmarks. These observatio
Externí odkaz:
https://doaj.org/article/a8b30413ff89465cb626e026f8c27cf5
Publikováno v:
Molecules, Vol 25, Iss 7, p 1500 (2020)
While loss-of-function mutations in the ATRX gene have been implicated as a driving force for a variety of pediatric brain tumors, as well as pancreatic neuroendocrine tumors, the role of ATRX in gene regulation and oncogenic development is not well-
Externí odkaz:
https://doaj.org/article/e53cf930c7e3463195605fb74acd610a
Autor:
Christopher O. Dusek, Radha Charan Dash, Kerry S. McPherson, Jackson T. Calhoun, Irina Bezsonova, Dmitry M. Korzhnev, M. Kyle Hadden
Publikováno v:
Biochemistry.
DNA damage tolerance (DDT) pathways enable cells to cope with a variety of replication blocks that threaten their ability to complete DNA replication. Helicase-like transcription factor (HLTF) plays a central role in the error-free DDT pathway, templ
Autor:
Rishabh Kejriwal, Tristan Evans, Joshua Calabrese, Lea Swistak, Lauren Alexandrescu, Michelle Cohen, Nahian Rahman, Niel Henriksen, Radha Charan Dash, M. Kyle Hadden, Nicola J. Stonehouse, David J. Rowlands, Natalie J. Kingston, Madeline Hartnoll, Samuel J. Dobson, Simon J. White
Publikováno v:
ChemMedChem. 18
Autor:
Rishabh Kejriwal, Tristan Evans, Joshua Calabrese, Lea Swistak, Lauren Alexandrescu, Michelle Cohen, Nahian Rahman, Niel Henriksen, Radha Charan Dash, M. Kyle Hadden, Nicola J. Stonehouse, David J. Rowlands, Natalie J. Kingston, Madeline Hartnoll, Samuel J. Dobson, Simon J. White
Publikováno v:
ChemMedChem. 18
Autor:
Rishabh Kejriwal, Tristan Evans, Joshua Calabrese, Lea Swistak, Lauren Alexandrescu, Michelle Cohen, Nahian Rahman, Niel Henriksen, Radha Charan Dash, M. Kyle Hadden, Nicola J. Stonehouse, David J. Rowlands, Natalie J. Kingston, Madeline Hartnoll, Samuel J. Dobson, Simon J. White
The enterovirus (EV) genus includes a number of important human and animal pathogens. EV-A71, EV-D68, poliovirus (PV), and coxsackievirus (CV) outbreaks have affected millions worldwide causing a range of upper respiratory, skin, neuromuscular diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22b7e3490fe45c7119a3b6fa7a156f60
https://doi.org/10.1101/2022.10.06.511132
https://doi.org/10.1101/2022.10.06.511132
Autor:
Marcello Stanzione, Jun Zhong, Edmond Wong, Thomas J. LaSalle, Jillian F. Wise, Antoine Simoneau, David T. Myers, Sarah Phat, Moshe Sade-Feldman, Michael S. Lawrence, M. Kyle Hadden, Lee Zou, Anna F. Farago, Nicholas J. Dyson, Benjamin J. Drapkin
Publikováno v:
Science Advances. 8
In small cell lung cancer (SCLC), acquired resistance to DNA-damaging therapy is challenging to study because rebiopsy is rarely performed. We used patient-derived xenograft models, established before therapy and after progression, to dissect acquire
Autor:
Jiachen Wen, Radha Charan Dash, Angela M. Zaino, Noah J. Harrahill, Jackson T. Calhoun, Christopher O. Dusek, Shana R. Morel, Matthew Russolillo, M. Kyle Hadden
Publikováno v:
Bioorganic Chemistry. 132:106387