Zobrazeno 1 - 10
of 903
pro vyhledávání: '"M. Krahn"'
Autor:
Ludovic Reveiz, Carla Saenz, Maxwell J Smith, Michelle M Haby, Timothy M Krahn, Sarah Carracedo
Publikováno v:
BMJ Global Health, Vol 9, Iss 9 (2024)
The calls for health research to be collaborative are ubiquitous—even as part of a recent World Health Assembly resolution on clinical trials—yet the arguments in support of collaborative research have been taken for granted and are absent in the
Externí odkaz:
https://doaj.org/article/aac93f142e994bf4b6a22c9c7302b8ab
Autor:
Jacob Gordon, Fleur L. Chapus, Elizabeth G. Viverette, Jason G. Williams, Leesa J. Deterding, Juno M. Krahn, Mario J. Borgnia, Joseph Rodriguez, Alan J. Warren, Robin E. Stanley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
PELP1 is a large scaffolding protein implicated in many cellular activities, including ribosome assembly as part of the Rix1 complex, comprising PELP1, WDR18, TEX10 and other components. Here, authors present the cryo-EM structure of PELP1 in complex
Externí odkaz:
https://doaj.org/article/7a28ba5ed69749b48501c3dc0b091105
Autor:
Thomas W. Kirby, Scott A. Gabel, Eugene F. DeRose, Lalith Perera, Juno M. Krahn, Lars C. Pedersen, Robert E. London
Publikováno v:
Biomolecules, Vol 13, Iss 11, p 1603 (2023)
Formation of active HIV-1 reverse transcriptase (RT) proceeds via a structural maturation process that involves subdomain rearrangements and formation of an asymmetric p66/p66′ homodimer. These studies were undertaken to evaluate whether the inform
Externí odkaz:
https://doaj.org/article/376b12fa42bb4eceacdfd0459bcc8b10
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-18 (2021)
Abstract Background Human cancer cell line profiling and drug sensitivity studies provide valuable information about the therapeutic potential of drugs and their possible mechanisms of action. The goal of those studies is to translate the findings fr
Externí odkaz:
https://doaj.org/article/4b1de6683af848de92c5bf39c5ce389f
Autor:
Monica C. Pillon, Meredith N. Frazier, Lucas B. Dillard, Jason G. Williams, Seda Kocaman, Juno M. Krahn, Lalith Perera, Cassandra K. Hayne, Jacob Gordon, Zachary D. Stewart, Mack Sobhany, Leesa J. Deterding, Allen L. Hsu, Venkata P. Dandey, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nsp15 is a uridine specific endoribonuclease present in all coronaviruses. Here, the authors determine the cryo-EM structures of SARS-CoV-2 Nsp15 in the apo and UTP-bound states, which together with biochemical experiments, mass spectrometry and mole
Externí odkaz:
https://doaj.org/article/3b3bd68422cc4508a02721056de1a082
Autor:
Margaret M. Krahn, Gina M. Ylitalo, Douglas G. Burrows, John Calambokidis, Sue E. Moore, Merrill Gosho, Patrick Gearin, Paul D. Plesha, Robert L. Brownell Jr., S. A. Blokhin, Karen L. Tilbury, Teri Rowles, John E. Stein
Publikováno v:
J. Cetacean Res. Manage.. 3:19-29
Organochlorine (OC) contaminant concentrations in tissues and lipid profiles in blubber are summarised for 101 gray whales (Eschrichtius robustus) from the eastern North Pacific stock. Samples were obtained from presumably healthy gray whales during
Publikováno v:
J. Cetacean Res. Manage.. 5:103-113
This paper reviews current scientific literature to provide information for avoiding errors commonly made in comparing and interpreting datasets from laboratories measuring organochlorine contaminants in cetaceans. Before making comparisons and inter
Autor:
Yu-Hua Lo, Mack Sobhany, Allen L. Hsu, Brittany L. Ford, Juno M. Krahn, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Rix7 is a type II AAA-ATPase that is required for the assembly of the large ribosomal subunit. Here the authors present the 4.5 Å cryo-EM structure of the Rix7 homohexamer with a polypeptide fragment bound in its central channel and provide insight
Externí odkaz:
https://doaj.org/article/532b14f2bbab448784ac75464a65da1f
Autor:
Margaret M. Krahn, David P. Herman, Gina M. Ylitalo, Catherine A. Sloan, Douglas G. Burrows, Roderick C. Hobbs, Barbara A. Mahoney, Gladis K. Yanagida, John Calambokidis, Sue E. Moore
Publikováno v:
J. Cetacean Res. Manage.. 6:175-189
The biopsy 2 via dart, trocar or surgery 2 is becoming the preferred protocol for sampling skin and blubber of many cetacean species, because a small sample from a healthy animal may provide better information than a larger sample collected via necro
Autor:
Amanda A. Riccio, Jonathan Bouvette, Matthew J. Longley, Juno M. Krahn, Mario J. Borgnia, William C. Copeland
Publikováno v:
Methods. 205:263-270
The mitochondrial replisome replicates the 16.6 kb mitochondria DNA (mtDNA). The proper functioning of this multicomponent protein complex is vital for the integrity of the mitochondrial genome. One of the critical protein components of the mitochond