Zobrazeno 1 - 10
of 505
pro vyhledávání: '"M. Koomen"'
Autor:
M. A. Voronkova, B. Johnson, N. Gandhi, J. M. Koomen, M Patrick, S. Shanthi Bhupathi, V. M. Wu, A. Elliott, A. Vanderwalde, B. Halmos, L. A. Hazlehurst
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract We have identified endoplasmic reticulum oxidoreductase 1 alpha (ERO1A) as a poor prognostic indicator in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (EGFR MUT-NSCLC). In addition, comparison of high versus low
Externí odkaz:
https://doaj.org/article/235773db14064b1da23ffd8eff9c4a28
Autor:
Hilal Ozakinci, MD, Aileen Y. Alontaga, PhD, Pedro Cano, MD, John M. Koomen, PhD, Bradford A. Perez, MD, Amer A. Beg, PhD, Alberto A. Chiappori, MD, Eric B. Haura, MD, Theresa A. Boyle, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 11, Pp 100723- (2024)
Introduction: The translation of gene expression profiles of SCLC to clinical testing remains relatively unexplored. In this study, gene expression variations in SCLC were evaluated to identify potential biomarkers. Methods: RNA expression profiling
Externí odkaz:
https://doaj.org/article/ea0254e38bb7448e97135d59c5c6d059
Autor:
Surbhi Chouhan, Dhivya Sridaran, Cody Weimholt, Jingqin Luo, Tiandao Li, Myles C. Hodgson, Luana N. Santos, Samantha Le Sommer, Bin Fang, John M. Koomen, Markus Seeliger, Cheng-Kui Qu, Armelle Yart, Maria I. Kontaridis, Kiran Mahajan, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded by PTPN11), promotes developmental disorders and several malignancies by varying phosphatase activity. We uncovered that SHP2 is a distinct class of
Externí odkaz:
https://doaj.org/article/8786074726574cf993ac21c17b758fad
Autor:
Qian Liu, Emma Adhikari, Daniel K. Lester, Bin Fang, Joseph O. Johnson, Yijun Tian, Andrea T. Mockabee-Macias, Victoria Izumi, Kelly M. Guzman, Michael G. White, John M. Koomen, Jennifer A. Wargo, Jane L. Messina, Jianfei Qi, Eric K. Lau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Melanoma incidence and mortality rates are historically higher for men than women. Although emerging studies have highlighted tumorigenic roles for the male sex hormone androgen and its receptor (AR) in melanoma, cellular and molecular mecha
Externí odkaz:
https://doaj.org/article/1d6b5538888248d5b44646f3fe07e1be
Autor:
Michael F. Emmons, Richard L. Bennett, Alberto Riva, Kanchan Gupta, Larissa Anastasio Da Costa Carvalho, Chao Zhang, Robert Macaulay, Daphne Dupéré-Richér, Bin Fang, Edward Seto, John M. Koomen, Jiannong Li, Y. Ann Chen, Peter A. Forsyth, Jonathan D. Licht, Keiran S. M. Smalley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Melanomas can adopt multiple transcriptional states. Little is known about the epigenetic drivers of these cell states, limiting our ability to regulate melanoma heterogeneity. Here, we identify stress-induced HDAC8 activity as driving melan
Externí odkaz:
https://doaj.org/article/eaa6d6439c614e83a09975f61db4c4e0
Autor:
M. Ghariq, W. B. van den Hout, O. M. Dekkers, M. Bootsma, B. de Groot, J. G. J. Groothuis, M. P. M. Harms, M. E. W. Hemels, E. C. A. Kaal, E. M. Koomen, F. J. de Lange, S. Y. G. Peeters, I. A. van Rossum, J. H. W. Rutten, E. W. van Zwet, J. G. van Dijk, R. D. Thijs, on behalf of the SYNERGY Consortium
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Syncope management is fraught with unnecessary tests and frequent failure to establish a diagnosis. We evaluated the potential of implementing the 2018 European Society of Cardiology (ESC) Syncope Guidelines regarding diagnostic y
Externí odkaz:
https://doaj.org/article/d5f9c4ecf56944c49da5af0c4bdfd679
Autor:
Emma Adhikari, Qian Liu, Joseph Johnson, Paul Stewart, Viktoriya Marusyk, Bin Fang, Victoria Izumi, Kiah Bowers, Kelly M. Guzman, John M. Koomen, Andriy Marusyk, Eric K. Lau
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113463- (2023)
Summary: Brain metastasis cancer-associated fibroblasts (bmCAFs) are emerging as crucial players in the development of breast cancer brain metastasis (BCBM), but our understanding of the underlying molecular mechanisms is limited. In this study, we a
Externí odkaz:
https://doaj.org/article/c94698fc17e54b619ec84e1ff20702ab
Autor:
Aya G. Elmarsafawi, Rebecca S. Hesterberg, Mario R. Fernandez, Chunying Yang, Lancia N.F. Darville, Min Liu, John M. Koomen, Otto Phanstiel IV, Reginald Atkins, John E. Mullinax, Shari A. Pilon-Thomas, Frederick L. Locke, Pearlie K. Epling-Burnette, John L. Cleveland
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
Glutaminolysis is a hallmark of the activation and metabolic reprogramming of T cells. Isotopic tracer analyses of antigen-activated effector CD8+ T cells revealed that glutamine is the principal carbon source for the biosynthesis of polyamines putre
Externí odkaz:
https://doaj.org/article/b2a468345105429b88b1c9a8b533e6c4
Autor:
M. L. F. van Velthuysen, S. van Eeden, S. le Cessie, M. de Boer, H. van Boven, B. M. Koomen, F. Roozekrans, J. Bart, W. Timens, Q. J. M. Voorham
Publikováno v:
BMC Health Services Research, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background The COVID-19 pandemic has a huge impact on healthcare provided. The nationwide pathology registry of the Netherlands, PALGA, offers an outstanding opportunity to measure this impact for diseases in which pathology examinations are
Externí odkaz:
https://doaj.org/article/7a5bcb8d0088498e996c851f55de7dd9
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Although supported housing facilities (SHF) appear to be an ideal setting for supporting people with severe mental illness (SMI) to obtain a healthier lifestyle, little is known about the effects of lifestyle interventions in SHF and the factors cont
Externí odkaz:
https://doaj.org/article/cba95809c5414d3999c7dfeaff1a5bc6