Zobrazeno 1 - 10
of 95
pro vyhledávání: '"M. Konai"'
Autor:
Divakara S S M Uppu, Mohini M Konai, Paramita Sarkar, Sandip Samaddar, Isabel C M Fensterseifer, Celio Farias-Junior, Paramanandam Krishnamoorthy, Bibek R Shome, Octávio L Franco, Jayanta Haldar
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183263 (2017)
Chronic bacterial biofilms place a massive burden on healthcare due to the presence of antibiotic-tolerant dormant bacteria. Some of the conventional antibiotics such as erythromycin, vancomycin, linezolid, rifampicin etc. are inherently ineffective
Externí odkaz:
https://doaj.org/article/8f707a6c37594fdfb46815e8b37e5bf9
Autor:
Kathakali De, Jayanta Haldar, Peter N. Monk, Swagatam Barman, Mohini M. Konai, Utsarga Adhikary, Rahaf Issa, Sheila MacNeil
Publikováno v:
ACS Infectious Diseases. 6:703-714
The role of molecular arrangement of hydrophobic and hydrophilic groups for designing membrane-active molecules remains largely ambiguous. To explore this aspect, herein we report a series of membrane-active small molecules by varying the spatial dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c4225b42177cfdc8c093253d9971b7
https://doi.org/10.1021/acsinfecdis.9b00334
https://doi.org/10.1021/acsinfecdis.9b00334
Autor:
Chandradhish Ghosh, Goutham B Manjunath, Mohini M Konai, Divakara S S M Uppu, Jiaul Hoque, Krishnamoorthy Paramanandham, Bibek R Shome, Jayanta Haldar
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144094 (2015)
Development of synthetic strategies to combat Staphylococcal infections, especially those caused by methicillin resistant Staphyloccus aureus (MRSA), needs immediate attention. In this manuscript we report the ability of aryl-alkyl-lysines, simple me
Externí odkaz:
https://doaj.org/article/92683e8727d74c06af8e26c84ca16f94
Autor:
Jayanta Haldar, Mohini M. Konai
Publikováno v:
ACS Infectious Diseases. 6:91-99
The priority pathogen list published by the World Health Organization (WHO) has categorized carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa as the top two critical pathogens, and hence, the development of novel antibacterial s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45649e4f2e53bd36a0ed24229a7b6f45
https://doi.org/10.1021/acsinfecdis.9b00221
https://doi.org/10.1021/acsinfecdis.9b00221
Publikováno v:
ACS Applied Materials & Interfaces. 11:33559-33572
An optimum hydrophilic/hydrophobic balance has been recognized as a crucial parameter in designing cationic polymers that mimic antimicrobial peptides (AMPs). To date, this balance was achieved either by hydrophilicity variation through altering the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5524e79895ac3de2b658285123cca2d8
https://doi.org/10.1021/acsami.9b09016
https://doi.org/10.1021/acsami.9b09016
Autor:
Stuart D. Dowall, Kevin Bewley, Robert J. Watson, Seshadri S. Vasan, Chandradhish Ghosh, Mohini M. Konai, Gro Gausdal, James B. Lorens, Jason Long, Wendy Barclay, Isabel Garcia-Dorival, Julian Hiscox, Andrew Bosworth, Irene Taylor, Linda Easterbrook, James Pitman, Sian Summers, Jenny Chan-Pensley, Simon Funnell, Julia Vipond, Sue Charlton, Jayanta Haldar, Roger Hewson, Miles W. Carroll
Publikováno v:
Viruses, Vol 8, Iss 11, p 277 (2016)
In light of the recent outbreak of Ebola virus (EBOV) disease in West Africa, there have been renewed efforts to search for effective antiviral countermeasures. A range of compounds currently available with broad antimicrobial activity have been test
Externí odkaz:
https://doaj.org/article/7dc2cb79f6f64d30b56a604b5dc35a8e
Autor:
Khatija Tabbasum, Natalia Sharma, Mohini M. Konai, Jayanta Haldar, Prashant Garg, Iqbal Pakrudheen, Swagatam Barman
Publikováno v:
Chemical communications (Cambridge, England). 56(14)
Cyclam-based antibacterial molecules (CAMs) that display potent activity against both the planktonic and stationary phase of multidrug-resistant Gram-negative bacteria were rationally designed. The optimized compound retained its activity in human pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524b864cc5b97490e2eac11e4eda397c
https://pubmed.ncbi.nlm.nih.gov/31970367
https://pubmed.ncbi.nlm.nih.gov/31970367
Bacteria are increasingly developing resistance against the antibiotics of last resort, which has created enormous threats in the face of global public health. In order to address this clinical challenge, there is a continuous effort toward the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f556ce4c303ab089298e76d670709564
https://doi.org/10.1016/b978-0-12-818480-6.00004-7
https://doi.org/10.1016/b978-0-12-818480-6.00004-7
Autor:
Mohini M. Konai, Gianfranco Bocchinfuso, Jayanta Haldar, Sandip Samaddar, Valerio Santucci, Lorenzo Stella
Publikováno v:
Chemical Communications. 54:4943-4946
Here we report the design of membrane-active peptidomimetic molecules with a tunable arrangement of hydrophobic and polar groups. In spite of having the same chemical composition, the effective hydrophobicities of the compounds were different as a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816a02efd788512ec9acc85324fda6ec
https://doi.org/10.1039/c8cc01926f
https://doi.org/10.1039/c8cc01926f
Autor:
Jubi Jacob, Sunil Varughese, B. S. Dileep Kumar, Mohini M. Konai, Chandrasekhar Challa, Jayanta Haldar, Ravi S. Lankalapalli, Jaice Ravindran
Publikováno v:
ACS Omega, Vol 2, Iss 8, Pp 5187-5195 (2017)
Easily accessible 3,3′-diindolylmethanes (DIMs) were utilized to generate a focused library of indolo[2,3-b]quinolines (2), chromeno[2,3-b]indoles (3), and 3-alkenyl-oxindoles (4) under 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-mediated oxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99ef50751ea33262773be358ef3521a
https://doi.org/10.1021/acsomega.7b00840
https://doi.org/10.1021/acsomega.7b00840