Zobrazeno 1 - 10
of 386
pro vyhledávání: '"M. Knipe"'
Autor:
Yue Deng, Yuqi Lin, Siyu Chen, Yuhang Xiang, Hongjia Chen, Shuyuan Qi, Hyung Suk Oh, Biswajit Das, Gloria Komazin-Meredith, Jean M. Pesola, David M. Knipe, Donald M. Coen, Dongli Pan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Herpes simplex virus 1 (HSV-1) latent infection entails repression of viral lytic genes in neurons. By functional screening using luciferase-expressing HSV-1, we identify ten neuron-specific microRNAs potentially repressing HSV-1 neuronal re
Externí odkaz:
https://doaj.org/article/410423a0a7d541e0b07de9835ebc0df5
Autor:
Jonathan Sundstrom, Emma Vanderleeden, Nathaniel J. Barton, Sambra D. Redick, Pepper Dawes, Liam F. Murray, Meagan N. Olson, Khanh Tran, Samantha M. Chigas, Adrian R. Orszulak, George M. Church, Benjamin Readhead, Hyung Suk Oh, David M. Harlan, David M. Knipe, Jennifer P. Wang, Yingleong Chan, Elaine T. Lim
Publikováno v:
Cells, Vol 13, Iss 23, p 1978 (2024)
Viral infections leading to inflammation have been implicated in several common diseases, such as Alzheimer’s disease (AD) and type 1 diabetes (T1D). Of note, herpes simplex virus 1 (HSV-1) has been reported to be associated with AD. We sought to i
Externí odkaz:
https://doaj.org/article/3b3add34bc8e44acbd5c612c96c50812
Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physician
Autor:
Peter M. Howley, David M. Knipe
Now in four convenient volumes, Field's Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus fam
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Productive replication of herpes simplex virus (HSV) relies upon a well-ordered transcriptional cascade flowing from immediate-early (IE) to early (E) to late (L) gene products. While several virus-encoded transcriptional activators are invo
Externí odkaz:
https://doaj.org/article/07f28e9df399451b8e7ddebf98938a8e
Autor:
Michael J. Walsh, Courtney T. Stump, Rakeeb Kureshi, Patrick Lenehan, Lestat R. Ali, Michael Dougan, David M. Knipe, Stephanie K. Dougan
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112219- (2023)
Summary: Tumors in immune equilibrium are held in balance between outgrowth and destruction by the immune system. The equilibrium phase defines the duration of clinical remission and stable disease, and escape from equilibrium remains a major clinica
Externí odkaz:
https://doaj.org/article/f1f8592f2d8e4bfab43410d828e98a6f
Autor:
Tao Peng, Khamsone Phasouk, Catherine N. Sodroski, Sijie Sun, Yon Hwangbo, Erik D. Layton, Lei Jin, Alexis Klock, Kurt Diem, Amalia S. Magaret, Lichen Jing, Kerry Laing, Alvason Li, Meei-Li Huang, Max Mertens, Christine Johnston, Keith R. Jerome, David M. Koelle, Anna Wald, David M. Knipe, Lawrence Corey, Jia Zhu
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tissue-resident-memory T cells (TRM) populate the body’s barrier surfaces, functioning as frontline responders against reencountered pathogens. Understanding of the mechanisms by which CD8TRM achieve effective immune protection remains incomplete i
Externí odkaz:
https://doaj.org/article/8a1eece0c94043338e4530333d1db25a
Autor:
Sarah Hulsey Stubbs, Marjorie Cornejo Pontelli, Nischay Mishra, Changhong Zhou, Juliano de Paula Souza, Rosa Maria Mendes Viana, W. Ian Lipkin, David M. Knipe, Eurico Arruda, Sean P. J. Whelan
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Oropouche virus (OROV) infection of humans is associated with a debilitating febrile illness that can progress to meningitis or encephalitis. First isolated from a forest worker in Trinidad and Tobago in 1955, the arbovirus OROV has since be
Externí odkaz:
https://doaj.org/article/769e93f927cb42e19a1bbf60c6eef537
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009567 (2021)
Histones are rapidly loaded on the HSV genome upon entry into the nucleus of human fibroblasts, but the effects of histone loading on viral replication have not been fully defined. We showed recently that ATRX is dispensable for de novo deposition of
Externí odkaz:
https://doaj.org/article/43f099a4bbd84e53a775f49f3d824d21
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009281 (2021)
Intrinsic resistance is a crucial line of defense against virus infections, and members of the Tripartite Ring Interaction Motif (TRIM) family of proteins are major players in this system, such as cytoplasmic TRIM5α or nuclear promyelocytic leukemia
Externí odkaz:
https://doaj.org/article/60218ac4f83d49968f176ef3c3ddbd6c