Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips

Autor: H. H. T. Middelkamp, A. H. A. Verboven, A. G. De Sá Vivas, C. Schoenmaker, T. M. Klein Gunnewiek, R. Passier, C. A. Albers, P. A. C. ‘t Hoen, N. Nadif Kasri, A. D. van der Meer

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract In vitro neuronal models are essential for studying neurological physiology, disease mechanisms and potential treatments. Most in vitro models lack controlled vasculature, despite its necessity in brain physiology and disease. Organ-on-chip

Externí odkaz: https://doaj.org/article/801201348ddd426a9c4934d59048c886

Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks

Autor: Teun M. Klein Gunnewiek, Maria Rosaria Vitale, Brooke L. Latour, Sophie Jansen, Nael Nadif Kasri, Jon-Ruben van Rhijn, Dirk Schubert, Eline J.H. van Hugte, Martijn Selten, Jitske Bak, Anouk H.A. Verboven, Alessia Anania, Ilse M. van der Werf, Katrin Linda, Klaus-Peter Lesch, Johanna E. M. Zöller, Hans van Bokhoven, Chantal Schoenmaker, Moritz Negwer, Britt Mossink, Monica Frega, Jason M. Keller, Shan Wang, Astrid R. Oudakker

Publikováno v: Molecular Psychiatry, 27, 1-18
Molecular Psychiatry, 27, 1-18. Nature Publishing Group
Mol Psychiatry
Molecular Psychiatry, 27, 1, pp. 1-18
Molecular Psychiatry, 27(1), 1-18. Nature Publishing Group

Activity in the healthy brain relies on a concerted interplay of excitation (E) and inhibition (I) via balanced synaptic communication between glutamatergic and GABAergic neurons. A growing number of studies imply that disruption of this E/I balance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcf03da1f0e21468baa3ed5c5d714df
https://hdl.handle.net/2066/248849

Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders

Autor: Marina P Hommersom, Chantal Schoenmaker, Astrid R. Oudakker, Katrin Linda, Lynn Devilee, Elly Lewerissa, Nael Nadif Kasri, Anouk H.A. Verboven, Bert B.A. de Vries, Michele Gabriele, Giuseppe Testa, David A. Koolen, Hans van Bokhoven, Monica Frega, Teun M. Klein Gunnewiek, Edda Ulferts, Dirk Schubert

Publikováno v: Autophagy, 18, 2, pp. 423-442
Autophagy, 18(2), 423-442. Landes Bioscience
Autophagy, 18, 423-442

Contains fulltext : 248864.pdf (Publisher’s version ) (Open Access) Macroautophagy (hereafter referred to as autophagy) is a finely tuned process of programmed degradation and recycling of proteins and cellular components, which is crucial in neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef0853aed0d4bd89a0459755da98920
https://repository.ubn.ru.nl/handle/2066/248864

Sonlicromanol improves neuronal network dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in iPSC-derived neurons

Autor: Teun M. Klein Gunnewiek, Jan A.M. Smeitink, Chantal Schoenmaker, Herma Renkema, Bert B.A. de Vries, Nael Nadif Kasri, Julien Beyrath, Iris Pelgrim, Peter-Bram A.C. ’t Hoen, Anouk H.A. Verboven, Tamas Kozicz, Mark Hogeweg

Publikováno v: Stem Cell Reports, 16, 9, pp. 2197-2212
ISSCR
Stem Cell Reports, 16, 2197-2212
Stem Cell Reports

Summary Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is often caused by an adenine to guanine variant at m.3243 (m.3243A>G) of the MT-TL1 gene. To understand how this pathogenic variant affects the nervous system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c47ff44bd8a9bf01c1436acfdc0986
https://repository.ubn.ru.nl/handle/2066/237505

Sonlicromanol improves neuronal network dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in iPSC-derived neurons

Autor: Peter A C 't Hoen, Tamas Kozicz, Teun M. Klein Gunnewiek, Chantal Schoenmaker, Nael Nadif Kasri, Jan A.M. Smeitink, Herma Renkema, Anouk H.A. Verboven, Bert B.A. de Vries, Julien Beyrath, Mark Hogeweg

SummaryMitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is often caused by an adenine to guanine mutation at m.3243 (m.3243A>G) of the MT-TL1 gene (tRNAleu(UUR)). To understand how this mutation affects the nervous sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::483f705890f836617a3fb36c18ce6236
https://doi.org/10.1101/2020.08.11.246140