Zobrazeno 1 - 10
of 193
pro vyhledávání: '"M. Keyser"'
Autor:
Brian M. Keyser, Robert Leverette, Reagan McRae, John Wertman, Tom Shutsky, Ken Szeliga, Patrudu Makena, Kristen G. Jordan
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
IntroductionModern oral nicotine pouch products (ONPs) are a category of oral nicotine products which contain pharmaceutical-grade nicotine, flavors, and other food-grade ingredients but no tobacco leaf. Recent reports indicate that ONPs in general d
Externí odkaz:
https://doaj.org/article/c8167f896357405889fcb97b31216071
Autor:
Milly N. Kanobe, Gary M. Dull, John Darnell, Tao Jin, Buddy Brown, Jeff Coffield, Brian M. Keyser, Ian M. Fearon, Patrudu Makena, Sarah A. Baxter, Kristen G. Jordan
Publikováno v:
Environmental Advances, Vol 17, Iss , Pp 100580- (2024)
Compared to cigarette smoke, heated tobacco product (HTP) aerosol contains significantly fewer and lower levels of harmful and potentially harmful constituents (HPHCs). However, the impact on environmental air is relatively unexplored. Therefore, thi
Externí odkaz:
https://doaj.org/article/5bfa3d4350d944ff95c297c36938cb67
Publikováno v:
Cells, Vol 13, Iss 16, p 1399 (2024)
The high-affinity IgE receptor, FcεRI, is typically associated with type 2 effectors such as mast cells (MC). The relatively unique expression profile of FcεRI and accumulating evidence from pre-clinical and clinical settings, such as MC interactio
Externí odkaz:
https://doaj.org/article/b70a1ca5e9b24be28540edc5ceaaaa3a
Autor:
Brian M. Keyser, Kyung Soo Hong, Patricia DeLuca, Tao Jin, Bobbette A. Jones, Paul Nelson, Eckhardt Schmidt, Elaine K. Round
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract We report the findings from a randomized, parallel study designed to evaluate nicotine pharmacokinetics (PK) following 10 min of ad libitum use of electronic nicotine delivery system (ENDS) in four flavor variants. Subjects were randomized a
Externí odkaz:
https://doaj.org/article/7d10d89c84334401838d12c24b1fe583
Autor:
Brian M. Keyser, Robert Leverette, John Wertman, Tom Shutsky, Reagan McRae, Ken Szeliga, Patrudu Makena, Kristen Jordan
Publikováno v:
Toxics, Vol 12, Iss 2, p 129 (2024)
Assessment of in vitro cytotoxicity is an important component of tobacco product toxicological evaluations. However, current methods of regulatory testing involve exposing monolayer cell cultures to various preparations of aerosols from cigarettes or
Externí odkaz:
https://doaj.org/article/24ab6ebd951341529ce5e145f4948dbe
Autor:
Brian M. Keyser, Robert Leverette, Michael Hollings, Adam Seymour, Randy A. Weidman, Carlton J. Bequette, Kristen Jordan
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 1985-1992 (2022)
The rapid development associated with Next Generation Tobacco Products (NGTP) has necessitated the development of high throughput methodologies to test their genotoxic potential in vitro when compared to conventional cigarette smoke (CS). An assessme
Externí odkaz:
https://doaj.org/article/c010c6872662426d8f32d1c126f9a108
Autor:
Brian M. Keyser, Robert Leverette, Michael Hollings, Adam Seymour, Lesley Reeve, Wanda Fields
Publikováno v:
Toxicology Reports, Vol 6, Iss , Pp 1281-1288 (2019)
The Vitrocell® VC10® smoke exposure system offers multiple platforms for air liquid interface (ALI) and air agar interface (AAI) exposure that mimic in vivo conditions for assessing toxicological impact of whole smoke using in vitro assays. The aim
Externí odkaz:
https://doaj.org/article/1075d2bdef5f4a809d70929aae8cc66c
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240322 (2020)
Globally, economies and marine ecosystems are increasingly dependent on sustainable fisheries management (SFM) to balance social, economic, and conservation needs. The overarching objectives of SFM are to maximize both conservation and socio-economic
Externí odkaz:
https://doaj.org/article/ce51b14b965c455db0b3dbf1ef618e1b
Autor:
Holger P. Behrsing, Adam Wahab, Lindsey Ukishima, Chad Grodi, Stefan Frentzel, Stephanie Johne, Shinkichi Ishikawa, Shigeaki Ito, Roman Wieczorek, Jessica Budde, Brian M. Keyser, Linsey E. Haswell, David Thorne, Emma Bishop, Damien Breheny, Xuefei Cao, Qin Qin, Vivek Patel
Publikováno v:
Alternatives to Laboratory Animals. 50:293-309
The use of reconstituted human airway (RHuA) epithelial tissues to assess functional endpoints is highly relevant in respiratory toxicology, but standardised methods are lacking. In June 2015, the Institute for In Vitro Sciences (IIVS) held a technic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b714f002a830265eb184ea01e0518e
https://doi.org/10.1177/02611929221114383
https://doi.org/10.1177/02611929221114383
Autor:
Brian M. Keyser, Robert Leverette, Michael Hollings, Adam Seymour, Randy A. Weidman, Carlton J. Bequette, Kristen Jordan
Publikováno v:
Applied In Vitro Toxicology. 8:39-49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68ddd553ff3f10bb895fc9f15b63b9a3
https://doi.org/10.1089/aivt.2022.0001
https://doi.org/10.1089/aivt.2022.0001