Zobrazeno 1 - 10
of 304
pro vyhledávání: '"M. Kershaw"'
Autor:
Billy White, S. M. Ng, J. C. Agwu, T. G. Barrett, N. Birchmore, M. Kershaw, J. Drew, F. Kavvoura, J. Law, C. Moudiotis, E. Procter, P. Paul, F. Regan, P. Reilly, P. Sachdev, R. Sakremath, C. Semple, K. Sharples, M. Skae, A. Timmis, E. Williams, N. Wright, A. Soni
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Type 2 diabetes in young people is an aggressive disease with a greater risk of complications leading to increased morbidity and mortality during the most productive years of life. Prevalence in the UK and globally is rising yet e
Externí odkaz:
https://doaj.org/article/332104656f7d4c2080092ed78a00c390
Autor:
Benjamin P Flynn, Matthew T Birnie, Yvonne M Kershaw, Audrys G Pauza, Sohyoung Kim, Songjoon Baek, Mark F Rogers, Alex R Paterson, Diana A Stavreva, David Murphy, Gordon L Hager, Stafford L Lightman, Becky L Conway-Campbell
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)
Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam
Externí odkaz:
https://doaj.org/article/ebb7253002144d5885d6bce3701f46a0
Autor:
John R Pooley, Caroline A Rivers, Michael T Kilcooley, Susana N Paul, Ayse Derya Cavga, Yvonne M Kershaw, Serena Muratcioglu, Attila Gursoy, Ozlem Keskin, Stafford L Lightman
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227520 (2020)
Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind DNA as homodimers or MR-GR heterodimers to influence gene regulation in response to pulsatile basal or stress-evoked glucocorticoid secretion. Pulsed corticoste
Externí odkaz:
https://doaj.org/article/11c2522dd7dd458c928d75377d179719
Autor:
Matthew T. Birnie, Matthew D. B. Claydon, Oliver Troy, Benjamin P. Flynn, Mitsuhiro Yoshimura, Yvonne M. Kershaw, Zidong Zhao, Rebecca C. R. Demski-Allen, Gareth R. I. Barker, E. Clea Warburton, Zuner A. Bortolotto, Stafford L. Lightman, Becky L. Conway-Campbell
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Disrupted circadian activity is associated with many neuropsychiatric disorders. A major coordinator of circadian biological systems is adrenal glucocorticoid secretion which exhibits a pronounced preawakening peak that regulates metabolic, immune, a
Autor:
David W. Dawson, Ronald M. Evans, Christopher Liddle, Michael Downes, Mara H. Sherman, Claire A. Ostertag-Hill, Anna R. Lay, Kathleen M. Kershaw, Phillip Nguyen, Michael D. Arensman
Supplemental Figure 1. Calcipotriol does not inhibit Wnt signaling through VDR sequestration of β-catenin or induction of DKK1. (A) AsPC-1 cells were treated with 100 nM calcipotriol for 4 hours. Whole cell lysates were collected and immunoprecipita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0ba7bc344c319ae3335fc3c6c2e216
https://doi.org/10.1158/1541-7786.22514925
https://doi.org/10.1158/1541-7786.22514925
Autor:
David W. Dawson, Ronald M. Evans, Christopher Liddle, Michael Downes, Mara H. Sherman, Claire A. Ostertag-Hill, Anna R. Lay, Kathleen M. Kershaw, Phillip Nguyen, Michael D. Arensman
Supplemental Figure 3. Calcipotriol reduces VDR message while paradoxically increasing VDR protein levels. (A) VDR expression in AsPC-1 by qPCR after treatments described in Figure 3E. (B) Western blots for VDR or tubulin (loading control) for AsPC-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d63b1d85f186c412e6e26f2e2fe21f
https://doi.org/10.1158/1541-7786.22514919.v1
https://doi.org/10.1158/1541-7786.22514919.v1
Autor:
David W. Dawson, Ronald M. Evans, Christopher Liddle, Michael Downes, Mara H. Sherman, Claire A. Ostertag-Hill, Anna R. Lay, Kathleen M. Kershaw, Phillip Nguyen, Michael D. Arensman
Supplemental Table 1. QPCR PRIMERS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5239d797d10f01721f9bcfabcf116105
https://doi.org/10.1158/1541-7786.22514916
https://doi.org/10.1158/1541-7786.22514916
Autor:
David W. Dawson, Timothy R. Donahue, Nanping Wu, Kathleen M. Kershaw, Anna R. Lay, Donatello Telesca, Michael D. Arensman
Supplemental Figure 5. Gene ontology terms enriched in gene expression microarray analysis following β-catenin knockdown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00532a271e4e1bbc0c9691b717eda55e
https://doi.org/10.1158/1535-7163.22502377.v1
https://doi.org/10.1158/1535-7163.22502377.v1
Autor:
David W. Dawson, Ronald M. Evans, Christopher Liddle, Michael Downes, Mara H. Sherman, Claire A. Ostertag-Hill, Anna R. Lay, Kathleen M. Kershaw, Phillip Nguyen, Michael D. Arensman
Supplemental Figure 2. Calcipotriol does not alter LRP6 expression in Low-BAR/Low-VDR cell lines. (A) Western blot for LRP6 or tubulin (loading control) following treatment with vehicle or 10 μM calcipotriol. Representative experiments from 2-3 biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8b4c26ff72b4b0ef63b289bbb8526d
https://doi.org/10.1158/1541-7786.22514922
https://doi.org/10.1158/1541-7786.22514922
Autor:
David W. Dawson, Ronald M. Evans, Christopher Liddle, Michael Downes, Mara H. Sherman, Claire A. Ostertag-Hill, Anna R. Lay, Kathleen M. Kershaw, Phillip Nguyen, Michael D. Arensman
Supplemental Table 2. RNA-Seq analysis showing significant gene expression changes following 6 hour calcipotriol treatment of AsPC-1 cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a38ba81e925972aa79eb9dad5ea3db
https://doi.org/10.1158/1541-7786.22514913
https://doi.org/10.1158/1541-7786.22514913