Zobrazeno 1 - 10
of 42
pro vyhledávání: '"M. Kemal Aydintug"'
A Distinctive γδ T Cell Repertoire in NOD Mice Weakens Immune Regulation and Favors Diabetic Disease
Autor:
Rebecca L. O’Brien, Jennifer Matsuda, M. Kemal Aydintug, Niyun Jin, Swati Phalke, Willi K. Born
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1406 (2022)
Previous studies in mice and humans suggesting that γδ T cells play a role in the development of type 1 diabetes have been inconsistent and contradictory. We attempted to resolve this for the type 1 diabetes-prone NOD mice by characterizing their
Externí odkaz:
https://doaj.org/article/d06d10c62e234388b86272120509f23b
γδ T cells recognize the insulin B:9–23 peptide antigen when it is dimerized through thiol oxidation
Autor:
Brian J. Day, M. Kemal Aydintug, Gongyi Zhang, Aaron W. Michels, Li Zhang, Deming Sun, Rebecca L. O'Brien, Chao Wang, Willi K. Born, Dongchun Liang, Brooke Hirsch, J. M. Wands, George S. Eisenbarth
Publikováno v:
Molecular Immunology. 60:116-128
The insulin peptide B:9-23 is a natural antigen in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D). In addition to αβ T cells and B cells, γδ T cells recognize the peptide and infiltrate the pancreatic islets where the peptide i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c25b4ffdad41a87622f6a74a3cc363
https://doi.org/10.1016/j.molimm.2014.04.007
https://doi.org/10.1016/j.molimm.2014.04.007
Autor:
Megan K. L. MacLeod, M. Kemal Aydintug, Greg A. Kirchenbaum, Joshua Loomis, Amy S. McKee, Yafei Huang, Willi K. Born, Rebecca L. O'Brien, Deming Sun, Ross M. Kedl, Claudia Jakubzick, Jordan Jacobelli
Publikováno v:
The Journal of Immunology. 190:913-921
We re-examined the observation that γδ T cells, when transferred from mice tolerized to an inhaled conventional Ag, suppress the allergic IgE response to this Ag specifically. Using OVA and hen egg lysozyme in crisscross fashion, we confirmed the A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d11ed73c0a5ba370730583511b8866f4
https://doi.org/10.4049/jimmunol.1202230
https://doi.org/10.4049/jimmunol.1202230
Autor:
J. M. Wands, Jennifer L. Chain, Philip L. Simonian, Andrew P. Fontenot, Niyun Jin, Willi K. Born, Yafei Huang, Youn-Soo Hahn, Rebecca L. O'Brien, M. Kemal Aydintug, Christina L. Roark
Publikováno v:
The open immunology journal
The resident population of γδ T cells in the normal lung is small but during lung inflammation, γδ T cells can increase dramatically. Histological analysis reveals diverse interactions between γδ T cells and other pulmonary leukocytes. Studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a24e4c2616b621c0bc6c3599229d8d
https://doi.org/10.2174/1874226200902020143
https://doi.org/10.2174/1874226200902020143
Autor:
M. Kemal Aydintug, Yafei Huang, Niyun Jin, Willi K. Born, J. M. Wands, Hua Huang, Christina L. Roark, Rebecca L. O'Brien
Publikováno v:
The Journal of Immunology. 183:849-855
It has been reported that the IgE response to allergens is influenced by γδ T cells. Intrigued by a study showing that airway challenge of mice with OVA induces in the spleen the development of γδ T cells that suppress the primary IgE response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd2997cc98c14a70069ef27adee644d4
https://doi.org/10.4049/jimmunol.0804104
https://doi.org/10.4049/jimmunol.0804104
Autor:
Erwin W. Gelfand, Niyun Jin, Christina L. Roark, Youn Soo Hahn, Yafei Huang, Willi K. Born, Rebecca L. O'Brien, J. M. Wands, M. Kemal Aydintug, Christian Taube, Nobuaki Miyahara
Publikováno v:
The Journal of Immunology. 182:2002-2010
Allergic airway hyperresponsiveness (AHR) in OVA-sensitized and challenged mice, mediated by allergen-specific Th2 cells and Th2-like invariant NKT (iNKT) cells, develops under the influence of enhancing and inhibitory γδ T cells. The AHR-enhancing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8983fb9021bf14ceed48e99f89a1e41
https://doi.org/10.4049/jimmunol.0803280
https://doi.org/10.4049/jimmunol.0803280
Publikováno v:
Molecular Immunology. 45:3253-3263
As only a handful of ligands have been identified, the general nature of the ligands recognized by γδ T cells remains unresolved. In this study, soluble multimerized γδ T cell receptors (smTCRs) representing the TCRs of two γδ T cell subsets co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08b421cd27d75d1f422d3fe0b0483e45
https://doi.org/10.1016/j.molimm.2008.02.031
https://doi.org/10.1016/j.molimm.2008.02.031
Autor:
J. M. Wands, M. Kemal Aydintug, Niyun Jin, Christina L. Roark, Willi K. Born, Rebecca L. O'Brien, Jena D. French
Publikováno v:
Journal of Clinical Immunology. 27:133-144
Lymphocytes expressing γδ T cell receptors (TCR) constitute an entire system of functionally specialized subsets that have been implicated in the regulation of immune responses, including responses to pathogens and allergens, and in tissue repair.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2099ace16ef80e3052c09d1ace7e0fa
https://doi.org/10.1007/s10875-007-9077-z
https://doi.org/10.1007/s10875-007-9077-z
Autor:
J. M. Wands, M. Kemal Aydintug, Christina L. Roark, Molly Johnston, Jena D. French, Niyun Jin, Willi K. Born, Rebecca L. O'Brien, Jennifer L. Chain
Publikováno v:
Immunological Reviews. 215:77-88
The gammadelta T-cell receptors (TCRs) are limited in their diversity, suggesting that their natural ligands may be few in number. Ligands for gammadeltaTCRs that have thus far been determined are predominantly of host rather than foreign origin. Cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::908d387f8fc86e7eeb43f65cd6966e5c
https://doi.org/10.1111/j.1600-065x.2006.00477.x
https://doi.org/10.1111/j.1600-065x.2006.00477.x
Autor:
Thiago Detanico, Willi K. Born, M. Kemal Aydintug, Simon R. Carding, Lawrence J. Wysocki, Greg A. Kirchenbaum, Chunjian Huang, Tamara L. Casper, Ryan A. Heiser, Rebecca L. O'Brien, Katja Aviszus, John C. Cambier, Andrew Getahun, Yafei Huang, Koichi Ikuta, Hua Huang
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 196(1)
We previously reported that selective ablation of certain γδ T cell subsets, rather than removal of all γδ T cells, strongly affects serum Ab levels in nonimmunized mice. This type of manipulation also changed T cells, including residual γδ T c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf6b8447181c796bc4cce6c77c54aec
https://pubmed.ncbi.nlm.nih.gov/26582947
https://pubmed.ncbi.nlm.nih.gov/26582947