Zobrazeno 1 - 10
of 117
pro vyhledávání: '"M. Keaton"'
Autor:
Jacob Joseph, Chang Liu, Qin Hui, Krishna Aragam, Zeyuan Wang, Brian Charest, Jennifer E. Huffman, Jacob M. Keaton, Todd L. Edwards, Serkalem Demissie, Luc Djousse, Juan P. Casas, J. Michael Gaziano, Kelly Cho, Peter W. F. Wilson, Lawrence S. Phillips, VA Million Veteran Program, Christopher J. O’Donnell, Yan V. Sun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
While the genetic basis of heart failure has been explored by genetic studies, the differences between subtypes are not well understood. Here, the authors performed genetic analyses on the two major subtypes of heart failure in a large biobank with g
Externí odkaz:
https://doaj.org/article/e336b622512a4d6490ab2f196676b283
Autor:
Nikhil K. Khankari, Jacob M. Keaton, Venexia M. Walker, Kyung Min Lee, Megan M. Shuey, Shoa L. Clarke, Kent R. Heberer, Donald R. Miller, Peter D. Reaven, Julie A. Lynch, Marijana Vujkovic, Todd L. Edwards
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104038- (2022)
Summary: Background: Maintaining a healthy lifestyle to reduce type 2 diabetes (T2D) risk is challenging and additional strategies for T2D prevention are needed. We evaluated several lipid control medications as potential therapeutic options for T2D
Externí odkaz:
https://doaj.org/article/40b062220d4c4983bd63137c4ba814a9
Autor:
Jacklyn N. Hellwege, Digna R. Velez Edwards, Ayush Giri, Chengxiang Qiu, Jihwan Park, Eric S. Torstenson, Jacob M. Keaton, O. D. Wilson, Cassianne Robinson-Cohen, Cecilia P. Chung, Christianne L. Roumie, Derek Klarin, Scott M. Damrauer, Scott L. DuVall, Edward Siew, Elvis A. Akwo, Matthias Wuttke, Mathias Gorski, Man Li, Yong Li, J. Michael Gaziano, Peter W. F. Wilson, Philip S. Tsao, Christopher J. O’Donnell, Csaba P. Kovesdy, Cristian Pattaro, Anna Köttgen, Katalin Susztak, Todd L. Edwards, Adriana M. Hung
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Persistently low levels of estimated glomerular filtration rate (eGFR) are a biomarker of chronic kidney disease. Here, the authors reinterpret the genetic architecture of kidney function across ancestries, to identify not only genes, but the tissue
Externí odkaz:
https://doaj.org/article/079924eecab64f9385dcb0971012c077
Autor:
Meijian Guan, Jacob M. Keaton, Latchezar Dimitrov, Pamela J. Hicks, Jianzhao Xu, Nicholette D. Palmer, Lijun Ma, Swapan K. Das, Yii-Der I. Chen, Josef Coresh, Myriam Fornage, Nora Franceschini, Holly Kramer, Carl D. Langefeld, Josyf C. Mychaleckyj, Rulan S. Parekh, Wendy S. Post, Laura J. Rasmussen-Torvik, Stephen S. Rich, Jerome I. Rotter, John R. Sedor, Denyse Thornley-Brown, Adrienne Tin, James G. Wilson, Barry I. Freedman, Donald W. Bowden, Maggie C. Y. Ng, FIND Consortium
Publikováno v:
Human Genomics, Vol 13, Iss 1, Pp 1-17 (2019)
Abstract Background End-stage kidney disease (ESKD) is a significant public health concern disproportionately affecting African Americans (AAs). Type 2 diabetes (T2D) is the leading cause of ESKD in the USA, and efforts to uncover genetic susceptibil
Externí odkaz:
https://doaj.org/article/5ac2ff9750de4ba8ac0b66d0614e77b6
Autor:
Meijian Guan, Jacob M. Keaton, Latchezar Dimitrov, Pamela J. Hicks, Jianzhao Xu, Nicholette D. Palmer, James G. Wilson, Barry I. Freedman, Donald W. Bowden, Maggie C.Y. Ng
Publikováno v:
Kidney International Reports, Vol 3, Iss 4, Pp 867-878 (2018)
Introduction: Compared with European Americans, African Americans (AAs) are at higher risk for developing end-stage kidney disease (ESKD). Genome-wide association studies (GWAS) have identified >70 genetic variants associated with kidney function and
Externí odkaz:
https://doaj.org/article/935b374cbce140bbba66b0daf8c6e73c
Autor:
Todd L. Edwards, Ayush Giri, Jacklyn N. Hellwege, Katherine E. Hartmann, Elizabeth A. Stewart, Janina M. Jeff, Michael J. Bray, Sarah A. Pendergrass, Eric S. Torstenson, Jacob M. Keaton, Sarah H. Jones, Radhika P. Gogoi, Helena Kuivaniemi, Kathryn L. Jackson, Abel N. Kho, Iftikhar J. Kullo, Catherine A. McCarty, Hae Kyung Im, Jennifer A. Pacheco, Jyotishman Pathak, Marc S. Williams, Gerard Tromp, Eimear E. Kenny, Peggy L. Peissig, Joshua C. Denny, Dan M. Roden, Digna R. Velez Edwards
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Uterine fibroids affect up to 77% of women by menopause and account for up to $34 billion in healthcare costs each year. Although fibroid risk is heritable, genetic risk for fibroids is not well understood. We conducted a two-stage case-control meta-
Externí odkaz:
https://doaj.org/article/31264c40f47649e09523e49d087a56fb
We show that inactivation of the protein kinase Cdk1/Cyclin B (Cdc28/Clb 2 in the budding yeast Saccharomyces cerevisiae) is not only necessary for cells to leave mitosis, as is well known, but also sufficient to trigger mitotic exit. Cells carrying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f64020f61a37cf6090c63bb79d685f4e
https://doi.org/10.21203/rs.3.rs-2787001/v1
https://doi.org/10.21203/rs.3.rs-2787001/v1
Autor:
Fei Chen, Ravi K. Madduri, Alex A. Rodriguez, Burcu F. Darst, Alisha Chou, Xin Sheng, Anqi Wang, Jiayi Shen, Edward J. Saunders, Suhn K. Rhie, Jeannette T. Bensen, Sue A. Ingles, Rick A. Kittles, Sara S. Strom, Benjamin A. Rybicki, Barbara Nemesure, William B. Isaacs, Janet L. Stanford, Wei Zheng, Maureen Sanderson, Esther M. John, Jong Y. Park, Jianfeng Xu, Ying Wang, Sonja I. Berndt, Chad D. Huff, Edward D. Yeboah, Yao Tettey, Joseph Lachance, Wei Tang, Christopher T. Rentsch, Kelly Cho, Benjamin H. Mcmahon, Richard B. Biritwum, Andrew A. Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Thomas A. Sellers, Kosj Yamoah, Adam B. Murphy, Dana C. Crawford, Alpa V. Patel, William S. Bush, Melinda C. Aldrich, Olivier Cussenot, Gyorgy Petrovics, Jennifer Cullen, Christine M. Neslund-Dudas, Mariana C. Stern, Zsofia Kote-Jarai, Koveela Govindasami, Michael B. Cook, Anand P. Chokkalingam, Ann W. Hsing, Phyllis J. Goodman, Thomas J. Hoffmann, Bettina F. Drake, Jennifer J. Hu, Jacob M. Keaton, Jacklyn N. Hellwege, Peter E. Clark, Mohamed Jalloh, Serigne M. Gueye, Lamine Niang, Olufemi Ogunbiyi, Michael O. Idowu, Olufemi Popoola, Akindele O. Adebiyi, Oseremen I. Aisuodionoe-Shadrach, Hafees O. Ajibola, Mustapha A. Jamda, Olabode P. Oluwole, Maxwell Nwegbu, Ben Adusei, Sunny Mante, Afua Darkwa-Abrahams, James E. Mensah, Halimatou Diop, Stephen K. Van Den Eeden, Pascal Blanchet, Jay H. Fowke, Graham Casey, Anselm J. Hennis, Alexander Lubwama, Ian M. Thompson, Robin Leach, Douglas F. Easton, Michael H. Preuss, Ruth J. Loos, Susan M. Gundell, Peggy Wan, James L. Mohler, Elizabeth T. Fontham, Gary J. Smith, Jack A. Taylor, Shiv Srivastava, Rosaline A. Eeles, John D. Carpten, Adam S. Kibel, Luc Multigner, Marie-Élise Parent, Florence Menegaux, Geraldine Cancel-Tassin, Eric A. Klein, Caroline Andrews, Timothy R. Rebbeck, Laurent Brureau, Stefan Ambs, Todd L. Edwards, Stephen Watya, Stephen J. Chanock, John S. Witte, William J. Blot, J. Michael Gaziano, Amy C. Justice, David V. Conti, Christopher A. Haiman
Publikováno v:
European Urology
European Urology, 2023, 84 (1), pp.13-21. ⟨10.1016/j.eururo.2023.01.022⟩
European Urology, 2023, 84 (1), pp.13-21. ⟨10.1016/j.eururo.2023.01.022⟩
Background: Genetic factors play an important role in prostate cancer (PCa) susceptibility.Objective: To discover common genetic variants contributing to the risk of PCa in men of African ancestry.Design, setting, and participants: We conducted a met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b42ff56b071fb413155ed348022ab4c
https://doi.org/10.1016/j.eururo.2023.01.022
https://doi.org/10.1016/j.eururo.2023.01.022
Autor:
Nathan T. James, Joseph H. Breeyear, Richard Caprioli, Todd Edwards, Brian Hachey, Prince J. Kannankeril, Jacob M. Keaton, Matthew D. Marshall, Sara L. Van Driest, Leena Choi
Publikováno v:
Br J Clin Pharmacol
AIM: Our objectives were to perform a population pharmacokinetic analysis of dexmedetomidine in children using remnant specimens and electronic health records (EHRs) and explore the impact of patient’s characteristics and pharmacogenetics on dexmed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6a7dd6c730ae4d0b5324467b769796
https://doi.org/10.1111/bcp.15194
https://doi.org/10.1111/bcp.15194
Autor:
Elizabeth A. Jasper, Todd L. Edwards, Jacklyn N. Hellwege, Digna R. Velez Edwards, Eric S. Torstenson, Sarah H. Jones, Jacob M. Keaton
Publikováno v:
Human Genetics. 140:1433-1440
Uterine fibroids disproportionately impact Black women. Evidence suggests Black women have earlier onset and higher cumulative risk. This risk disparity may be due an imbalance of risk alleles in one parental geographic ancestry subgroup relative to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb39f59b8f94baa6e2f7a13506169c0
https://doi.org/10.1007/s00439-021-02322-y
https://doi.org/10.1007/s00439-021-02322-y