Zobrazeno 1 - 10
of 332
pro vyhledávání: '"M. Kashuba"'
Autor:
Erick Leung, Mackenzie L. Cottrell, Craig Sykes, Nicole White, Angela D. M. Kashuba, Julie B. Dumond
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 1922-1930 (2023)
Abstract A priori use of mathematical modeling and simulation to predict outcomes from incomplete adherence or reduced frequency dosing strategies may mitigate the risk of clinical trial failure with HIV pre‐exposure prophylaxis regimens. We develo
Externí odkaz:
https://doaj.org/article/84690a7c263a4274a59a10aac8b74601
Autor:
Sonny R Elizaldi, Anil Verma, Zhong-Min Ma, Sean Ott, Dhivyaa Rajasundaram, Chase E Hawes, Yashavanth Shaan Lakshmanappa, Mackenzie L Cottrell, Angela D M Kashuba, Zandrea Ambrose, Jeffrey D Lifson, John H Morrison, Smita S Iyer
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011844 (2023)
Virologic suppression with antiretroviral therapy (ART) has significantly improved health outcomes for people living with HIV, yet challenges related to chronic inflammation in the central nervous system (CNS)-known as Neuro-HIV- persist. As primary
Externí odkaz:
https://doaj.org/article/ce674ebb75fd493f95211cc20d8047d2
Autor:
Isabella C. Young, Ivana Massud, Mackenzie L. Cottrell, Roopali Shrivastava, Panita Maturavongsadit, Alka Prasher, Andres Wong-Sam, Chuong Dinh, Tiancheng Edwards, Victoria Mrotz, James Mitchell, Josilene Nascimento Seixas, Aryani Pallerla, Allison Thorson, Amanda Schauer, Craig Sykes, Gabriela De la Cruz, Stephanie A. Montgomery, Angela D. M. Kashuba, Walid Heneine, Charles W. Dobard, Martina Kovarova, J. Victor Garcia, J. Gerardo Garcίa-Lerma, S. Rahima Benhabbour
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Ultra-long-acting delivery platforms for HIV pre-exposure prophylaxis (PrEP) may increase adherence and maximize public health benefit. We report on an injectable, biodegradable, and removable in-situ forming implant (ISFI) that is administe
Externí odkaz:
https://doaj.org/article/8c9e1df2e9064777a30af13581288fca
Autor:
Isabella C. Young, Ivana Massud, Mackenzie L. Cottrell, Roopali Shrivastava, Panita Maturavongsadit, Alka Prasher, Andres Wong-Sam, Chuong Dinh, Tiancheng Edwards, Victoria Mrotz, James Mitchell, Josilene Nascimento Seixas, Aryani Pallerla, Allison Thorson, Amanda Schauer, Craig Sykes, Gabriela De la Cruz, Stephanie A. Montgomery, Angela D. M. Kashuba, Walid Heneine, Charles W. Dobard, Martina Kovarova, J. Victor Garcia, J. Gerardo Garcίa-Lerma, S. Rahima Benhabbour
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/6a18aab38ad64106a8e0e7466f66fcbe
Autor:
Talisa S. Kinsale, Mackenzie L. Cottrell, Linying Li, Rhonda Brand, Greg Gatto, Ellen Luecke, Chasity Norton, Archana Krovi, Julie B. Dumond, Gauri Rao, Shekhar Yeshwante, Brian Van Horne, Ariane Van Der Straten, Angela D. M. Kashuba, Leah M. Johnson
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 201 (2024)
Long-acting injectable cabotegravir is more effective than daily oral PrEP at preventing HIV transmission due to improved adherence, but requires bi-monthly large-volume intramuscular injections. Subcutaneous (SC) contraceptive implants can be formul
Externí odkaz:
https://doaj.org/article/5e3b180f2a7545f595dc9df71e45e098
Autor:
Elias P Rosen, Nicole White, William M Gilliland, Roy R Gerona, Monica Gandhi, K Rivet Amico, Kenneth H Mayer, Roy M Gulick, Angela D M Kashuba
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0287449 (2023)
Objective measures of adherence for antiretrovirals used as pre-exposure prophylaxis (PrEP) are critical for improving preventative efficacy in both clinical trials and real-world application. Current objective adherence measures either reflect only
Externí odkaz:
https://doaj.org/article/9257563d388642a5ace4cf8a5851b359
Autor:
Isabella C. Young, Allison L. Thorson, Roopali Shrivastava, Craig Sykes, Amanda P. Schauer, Mackenzie L. Cottrell, Angela D. M. Kashuba, Soumya Rahima Benhabbour
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1487 (2023)
HIV continues to affect millions of men and women worldwide. The development of long-acting injectables for HIV prevention can overcome adherence challenges with daily oral prevention regimens by reducing dosing frequency and stigma. We previously de
Externí odkaz:
https://doaj.org/article/452e46d003b14a2fb58de1bcf70b2292
Autor:
S. Rahima Benhabbour, Martina Kovarova, Clinton Jones, Daijha J. Copeland, Roopali Shrivastava, Michael D. Swanson, Craig Sykes, Phong T. Ho, Mackenzie L. Cottrell, Anush Sridharan, Samantha M. Fix, Orrin Thayer, Julie M. Long, Daria J. Hazuda, Paul A. Dayton, Russell J. Mumper, Angela D. M. Kashuba, J. Victor Garcia
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Patient drug regime compliance is a major issue; sustained release implants could address this. Here, the authors report on a phase inverted in situ forming implant of PLGA for the sustained release of antiretroviral drugs and optimize and demonstrat
Externí odkaz:
https://doaj.org/article/8bc4a989ec17413397ece8fc45f93686
Autor:
Raju Khatri, John K. Fallon, Craig Sykes, Natasha Kulick, Rebecca J. B. Rementer, Taryn A. Miner, Amanda P. Schauer, Angela D. M. Kashuba, Kim A. Boggess, Kim L. R. Brouwer, Philip C. Smith, Craig R. Lee
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Pregnancy-related hormones (PRH) are recognized as important regulators of hepatic cytochrome P450 enzyme expression and function. However, the impact of PRH on the hepatic expression and function of uridine diphosphate glucuronosyltransferases (UGTs
Externí odkaz:
https://doaj.org/article/4cac6828a3614bad9e8e1bd1b1e4fcc3
Autor:
Jordan B. Joiner, Jasmine L. King, Roopali Shrivastava, Sarah Anne Howard, Mackenzie L. Cottrell, Angela D. M. Kashuba, Paul A. Dayton, Soumya Rahima Benhabbour
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 615 (2022)
Due to the versatility of the in situ forming implant (ISFI) drug delivery system, it is crucial to understand the effects of formulation parameters for clinical translation. We utilized ultrasound imaging and pharmacokinetics (PK) in mice to underst
Externí odkaz:
https://doaj.org/article/e1456fd0a3024fa69b3e22e9ff7b2cda