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Influence of VH CDR3 arginine and light chain pairing on DNA reactivity of a bacterial DNA-induced anti-DNA antibody from a BALB/c mouse

Autor: M K Wloch, S H Clarke, G S Gilkeson

Publikováno v: The Journal of Immunology. 159:6083-6090

Anti-DNA induced in BALB/c mice by immunization with bacterial (Escherichia coli) DNA resemble spontaneous anti-DNA from lupus mice in V gene use and cross-reactivity with other nuclear Ags, but lack the high V(H) CDR3 arginine content seen in anti-D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b784944a117e15e59a7c4b6116aecf6b
https://doi.org/10.4049/jimmunol.159.12.6083

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Molecular properties of anti-DNA induced in preautoimmune NZB/W mice by immunization with bacterial DNA

Autor: M K Wloch, A L Alexander, A M Pippen, D S Pisetsky, G S Gilkeson

Publikováno v: The Journal of Immunology. 158:4500-4506

To elucidate the mechanism of Ag drive in the anti-DNA response, the Ab response to bacterial DNA has been analyzed in normal and autoimmune mice. Preautoimmune NZB/W mice immunized with Escherichia coli dsDNA produce Abs that resemble spontaneous au

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28bb69bb145b1febe107e24300b8f87d
https://doi.org/10.4049/jimmunol.158.9.4500

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Differences in Vϰ gene utilization and VH CDR3 sequence among anti-DNA from C3H-lpr mice and lupus mice with nephritis

Autor: Anne M. Pippen, David S. Pisetsky, M. K. Wloch, Audrey L. Alexander, Gary S. Gilkeson

Publikováno v: European Journal of Immunology. 26:2225-2233

To investigate the molecular properties of anti-DNA from lpr mice that express high levels of anti-DNA without immune-mediated nephritis, the sequences of VH and V kappa genes encoding 11 monoclonal anti-DNA antibodies derived from C3H-lpr/lpr (C3H-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9129bb088dd8ff20afee4039352c332
https://doi.org/10.1002/eji.1830260939

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Binding analysis of antibodies produced by precursor and branchpoint intermediates of an anti-influenza hemagglutinin B cell clone. Parallel replacement mutations do not confer increased avidity for hemagglutinin

Autor: R C Rickert, M K Wloch, R L Hahn, S H Clarke

Publikováno v: The Journal of Immunology. 154:2209-2216

We have previously described a set of secondary (2 degrees) hybridomas that are specific for the Sb site of influenza hemagglutinin (HA(Sb)) and share the H37-68 ld (68ld). Cells producing 68ld Abs dominated the 2 degree response of one BALB/c mouse,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d457bd551afadbd4f569a3fb5ef9988c
https://doi.org/10.4049/jimmunol.154.5.2209

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The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. Nonrandom silent mutation and unequal numbers of VH and Vk mutations

Autor: S Clarke, R Rickert, M K Wloch, L Staudt, W Gerhard, M Weigert

Publikováno v: The Journal of Immunology. 145:2286-2296

We have determined the nucleotide sequences of the expressed VH and Vk genes from 13 secondary (2 degrees) hemagglutinin (HA) (Sb) specific hybridomas derived from a single mouse. These antibodies share an Id, H37-68 (68Id) that dominates the 2 degre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7219ffabc968ae8da361464d47186f61
https://doi.org/10.4049/jimmunol.145.7.2286

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Effect of a genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production by C57BL6 Fas(lpr) mice

Autor: Gary S. Gilkeson, Ivan Molano, M. K. Wloch, Hiroshi Watanabe, Audrey A. Alexander

Publikováno v: Clinical immunology (Orlando, Fla.). 94(1)

Terminal deoxynucleotidyl transferase (TdT) adds nontemplate coded nucleotides (N additions) between the recombining ends of immunoglobulin and T cell receptor genes. These nucleotides add significant diversity to the Ig and TCR repertoires. Amino ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae769f91b9a4562d249825a34b9f6cd4
https://pubmed.ncbi.nlm.nih.gov/10607487

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Influence of VH CDR3 arginine and light chain pairing on DNA reactivity of a bacterial DNA-induced anti-DNA antibody from a BALB/c mouse

Autor: M K, Wloch, S H, Clarke, G S, Gilkeson

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b6a480d0dab7f629c6a2ed5948d46bc
https://pubmed.ncbi.nlm.nih.gov/9550408

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Molecular properties of anti-DNA induced in preautoimmune NZB/W mice by immunization with bacterial DNA

Autor: M K, Wloch, A L, Alexander, A M, Pippen, D S, Pisetsky, G S, Gilkeson

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 158(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b79647c1f9271bdd640b0877ca0bb8ce
https://pubmed.ncbi.nlm.nih.gov/9127017

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Autor: R C, Rickert, M K, Wloch, R L, Hahn, S H, Clarke

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 154(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b377f0aedf555a7bcfb334dc0fbdd69c
https://pubmed.ncbi.nlm.nih.gov/7868894

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The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. Nonrandom silent mutation and unequal numbers of VH and Vk mutations

Autor: S, Clarke, R, Rickert, M K, Wloch, L, Staudt, W, Gerhard, M, Weigert

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 145(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2441eab348cf1b961bbcf2b9a78a198d
https://pubmed.ncbi.nlm.nih.gov/2398280

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