Zobrazeno 1 - 10
of 13
pro vyhledávání: '"M. K. O'Bryan"'
Autor:
M. S. Oud, R. M. Smits, H. E. Smith, F. K. Mastrorosa, G. S. Holt, B. J. Houston, P. F. de Vries, B. K. S. Alobaidi, L. E. Batty, H. Ismail, J. Greenwood, H. Sheth, A. Mikulasova, G. D. N. Astuti, C. Gilissen, K. McEleny, H. Turner, J. Coxhead, S. Cockell, D. D. M. Braat, K. Fleischer, K. W. M. D’Hauwers, E. Schaafsma, Genetics of Male Infertility Initiative (GEMINI) consortium, L. Nagirnaja, D. F. Conrad, C. Friedrich, S. Kliesch, K. I. Aston, A. Riera-Escamilla, C. Krausz, C. Gonzaga-Jauregui, M. Santibanez-Koref, D. J. Elliott, L. E. L. M. Vissers, F. Tüttelmann, M. K. O’Bryan, L. Ramos, M. J. Xavier, G. W. van der Heijden, J. A. Veltman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Germline de novo mutations can impact individual fitness, but their role in human male infertility is understudied. Trio-based exome sequencing identifies many new candidate genes affecting male fertility, including an essential regulator of male ger
Externí odkaz:
https://doaj.org/article/da39d7bc3438462b91547e5622b3b7e7
Publikováno v:
Human Reproduction. 37
Study question How does viscosity influence the flagellar beating behaviour of free-swimming bull, mouse, and human sperm? Summary answer Sperm flagellar beating behaviour exhibits a transition from an irregular three-dimensional (3D) beating at 5 mP
Autor:
S R Catford, J Halliday, S Lewis, M K O’Bryan, D J Handelsman, R J Hart, J McBain, L Rombauts, D J Amor, R Saffery, R I McLachlan
Publikováno v:
Human reproduction (Oxford, England). 37(12)
STUDY QUESTION Is the metabolic health of men conceived using ICSI different to that of IVF and spontaneously conceived (SC) men? SUMMARY ANSWER ICSI-conceived men aged 18–24 years, compared with SC controls, showed differences in some metabolic pa
Publikováno v:
Journal of andrology. 22(5)
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 57(1)
The synthesis of peptides containing 0, 1 and 2 cysteine residues related to the human sperm tail protein, tpx-1, is described. These synthetic peptides, following conjugation to keyhole limpet hemocyanin modified with maleimidobenzoic acid N-hydroxy
Publikováno v:
Molecular reproduction and development. 58(1)
Previously we reported the cloning of a member of the cysteine-rich secretory protein family, tpx-1, from a testis expression library using an outer dense fiber (ODF)-specific antiserum. Using immunohistochemical and immunoelectron microscopic techni
Publikováno v:
Biology of reproduction. 63(5)
In vitro data have indicated that nitric oxide (NO) inhibits Leydig cell testosterone production, suggesting that NO may play a role in the suppression of steroidogenesis and spermatogenic function during inflammation. Consequently, we investigated e
Publikováno v:
Biology of reproduction. 62(3)
Sertoli cell proliferation in the rat is completed by Days 15-20 postnatally. Thyroid hormones appear to regulate the duration of Sertoli cell proliferation, affecting adult Sertoli cell number and hence the capacity of the testis to produce sperm. I
Publikováno v:
Endocrinology. 141(1)
While it is well known that serious illness and inflammation reduce male fertility, the mechanisms involved are poorly understood. In adult male rats, a single injection of lipopolysaccharide at doses that induced either mild or severe inflammation,
Publikováno v:
Molecular reproduction and development. 50(3)
Screening of a rat testis expression library with an antiserum specific for an outer dense fibre (ODF) has led to the identification of a gene encoding for a putative protein previously unknown as a component of the sperm tail. This gene has been des