Zobrazeno 1 - 10
of 20
pro vyhledávání: '"M. K. Cathcart"'
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 9, Pp 1857-1865 (1995)
Upon activation, human peripheral blood monocytes and U937 cells oxidized low density lipoprotein (LDL), converting it to a cytotoxin. The oxidized LDL loses its ability to interact specifically with the native LDL (apoB/E) receptor and becomes a lig
Externí odkaz:
https://doaj.org/article/807769f4e92b4bde926dce2a419c8607
Autor:
V A Folcik, M K Cathcart
Publikováno v:
Journal of Lipid Research, Vol 35, Iss 9, Pp 1570-1582 (1994)
Low density lipoprotein that was oxidized by activated human monocytes was analyzed to determine the identity of oxidized fatty acids present and the conditions required for their formation. The oxidized lipids were also analyzed under conditions all
Externí odkaz:
https://doaj.org/article/9bcf7b50a7b24e39b0c2ccb483d8c275
Autor:
V, Kolenko, P, Rayman, B, Roy, M K, Cathcart, J, O'Shea, R, Tubbs, L, Rybicki, R, Bukowski, J, Finke
Publikováno v:
Blood. 93:2308-2318
The Janus kinase, JAK3 plays an important role in interleukin-2 (IL-2)–dependent signal transduction and proliferation of T lymphocytes. Our findings show that prostaglandin E2(PGE2) can inhibit upregulation of JAK3 protein in naive T cells and can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f360653e24b7d56508684dcd9167e4ad
https://doi.org/10.1182/blood.v93.7.2308.407k16_2308_2318
https://doi.org/10.1182/blood.v93.7.2308.407k16_2308_2318
Autor:
V Kolenko, Q Wang, M C Riedy, J O'Shea, J Ritz, M K Cathcart, P Rayman, R Tubbs, M Edinger, A Novick, R Bukowski, J Finke
Publikováno v:
The Journal of Immunology. 159:3057-3067
The proliferative capacity of T cells infiltrating human tumors is known to be impaired, possibly through their interaction with tumor. Here we demonstrate that soluble products derived from renal cell carcinoma (RCC-S) explants but not normal kidney
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478a9d1165686ac07a220707ef909db4
https://doi.org/10.4049/jimmunol.159.6.3057
https://doi.org/10.4049/jimmunol.159.6.3057
Publikováno v:
The Journal of Immunology. 159:1938-1944
Ceruloplasmin is a 132-kDa glycoprotein abundant in human plasma. It has multiple in vitro activities, including copper transport, lipid pro- and antioxidant activity, and oxidation of ferrous ion and aromatic amines; however, its physiologic role is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc3d386d6af5bc276ff404617adfdd2a
https://doi.org/10.4049/jimmunol.159.4.1938
https://doi.org/10.4049/jimmunol.159.4.1938
Publikováno v:
The Journal of Immunology. 145:254-259
Monocyte-mediated oxidation of low-density lipoprotein (LDL) converts the lipoprotein to a potent cytotoxin. The oxidation process requires monocyte activation and requires superoxide anion since it can be blocked by superoxide dismutase. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8745ca1e78b87c70d4096ce6b7d370c5
https://doi.org/10.4049/jimmunol.145.1.254
https://doi.org/10.4049/jimmunol.145.1.254
Autor:
E A, Bey, M K, Cathcart
Publikováno v:
Journal of lipid research. 41(3)
We previously reported that superoxide dismutase (SOD) blocked human monocyte oxidation of LDL and therefore concluded that superoxide anion (O(2)(.-)) was required for oxidation. Others, however, have suggested that SOD may inhibit by mechanisms alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7039476cf896ef1564a8bd3d954ab9a8
https://pubmed.ncbi.nlm.nih.gov/10706597
https://pubmed.ncbi.nlm.nih.gov/10706597
Autor:
P, Rayman, R G, Uzzo, V, Kolenko, T, Bloom, M K, Cathcart, L, Molto, A C, Novick, R M, Bukowski, T, Hamilton, J H, Finke
Publikováno v:
The cancer journal from Scientific American. 6
The development of an effective antitumor immune response is compromised in patients with renal cell carcinoma. Despite significant infiltration by T lymphocytes into renal tumors, no detectable induction of gene expression is associated with the gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ee5d3256adc479a0fe0173187265cd6
https://pubmed.ncbi.nlm.nih.gov/10685665
https://pubmed.ncbi.nlm.nih.gov/10685665
Autor:
Q, Li, M K, Cathcart
Publikováno v:
The Journal of biological chemistry. 272(4)
Our previous studies have shown that monocyte activation and release of O-2 are required for monocyte-mediated low density lipoprotein (LDL) lipid oxidation. We have also found that intracellular Ca2+ levels and protein kinase C activity are requisit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f791a44756cd3d04afe0e8cb6c15979c
https://pubmed.ncbi.nlm.nih.gov/8999952
https://pubmed.ncbi.nlm.nih.gov/8999952
Autor:
Q, Li, M K, Cathcart
Publikováno v:
The Journal of biological chemistry. 269(26)
Our previous studies have shown that human monocytes can oxidize native low density lipoprotein (LDL) and transform it to a cytotoxin. We also found that intracellular Ca2+ levels are integrally involved in lipid oxidation of LDL by activated monocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c8b28285ae85d8cfc9f03190a61a43e
https://pubmed.ncbi.nlm.nih.gov/8021258
https://pubmed.ncbi.nlm.nih.gov/8021258