Zobrazeno 1 - 10
of 17
pro vyhledávání: '"M. K. Bayliss"'
Publikováno v:
Xenobiotica. 37:832-854
The metabolism of the structurally related 5HT3 antagonists ondansetron, alosetron and GR87442 in the rat, dog and human was determined in hepatocytes, liver microsomes and human recombinant microsomes. The profiles of phase I metabolites were simila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6c06921759f42f387c96716f8ffd32e
https://doi.org/10.1080/00498250701485575
https://doi.org/10.1080/00498250701485575
Autor:
D E, Leahy, R, Duncan, H J, Ahr, M K, Bayliss, A B, de Boer, F, Darvas, J H, Fentem, J R, Fry, R, Hopkins, J B, Houston, J, Karlsson, G L, Kedderis, M K, Pratten, P, Prieto, D A, Smith, D W, Straughan
Publikováno v:
Alternatives to laboratory animals : ATLA. 25(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b28560c8d3f4fab1b1c60a87c4854f50
https://pubmed.ncbi.nlm.nih.gov/26554347
https://pubmed.ncbi.nlm.nih.gov/26554347
Autor:
M K Bayliss, D M Cross
Publikováno v:
Drug Metabolism Reviews. 32:219-240
Isolated hepatocytes and liver slices, in short-term suspension or longer-term culture, offer the prospect of providing qualitative metabolic information and quantitative pharmacokinetic parameters from key animal species and man at early stages of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23c7d036f69b0cda1748bef6a723619
https://doi.org/10.1081/dmr-100100574
https://doi.org/10.1081/dmr-100100574
Publikováno v:
Rapid Communications in Mass Spectrometry. 14:2039-2045
Recent years have seen increasing usage of large particle size stationary phases and ultra-high flow rate liquid chromatography/mass spectrometry (LC/MS) for rapid determination of pharmaceuticals in plasma without prior sample preparation. This lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dab4084bdff16746b970a146913b85e4
https://doi.org/10.1002/1097-0231(20001115)14:21<2039::aid-rcm130>3.0.co
https://doi.org/10.1002/1097-0231(20001115)14:21<2039::aid-rcm130>3.0.co
Publikováno v:
Xenobiotica. 29:253-268
1. The metabolism of loxtidine (1-methyl-5-[3-[3-[(1-piperidinyl) methyl] phenoxy] propyl] amino-1H-1,2,4-triazole-3-methanol) was studied in freshly isolated rat, dog and human hepatocytes. Metabolism in vitro was comparable with previously availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f07881ec70ec5b5865ea4278ecd173
https://doi.org/10.1080/004982599238650
https://doi.org/10.1080/004982599238650
Publikováno v:
Drug Metabolism Reviews. 27:471-495
(1995). The Effects of Hypoxia on Drug-Metabolizing Enzymes. Drug Metabolism Reviews: Vol. 27, No. 3, pp. 471-495.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f156af3f53f3a26f373d2f1291f30a4
https://doi.org/10.3109/03602539508998332
https://doi.org/10.3109/03602539508998332
Autor:
M K, Bayliss, P, Skett
Publikováno v:
Methods in molecular medicine. 2
The liver performs a wide range of physiologically important functions, including the synthesis and secretion of albumin, fibrinogen, and other plasma proteins; the synthesis of cholesterol and bile acids, and the metabolism of drugs, steroids, and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8498b7fd4b72d034cf2182c7bb961d16
https://pubmed.ncbi.nlm.nih.gov/21359755
https://pubmed.ncbi.nlm.nih.gov/21359755
Autor:
M K, Bayliss, L W, Frick
Publikováno v:
Current opinion in drug discoverydevelopment. 2(1)
The profound technological advances that are now occurring early in the drug discovery process have enabled lead identification groups to deliver very large numbers of promising compounds to the project teams responsible for lead optimization and can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5bf921cfa5ca5529d44ed4aa92f586a9
https://pubmed.ncbi.nlm.nih.gov/19649913
https://pubmed.ncbi.nlm.nih.gov/19649913
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 37(8)
The in vitro clearances of the 5HT3 antagonists, ondansetron, alosetron and GR87442 were investigated. Intrinsic clearances using either metabolite formation or substrate depletion methods were equivalent (R2 = 0.95). Hepatocytes from preclinical spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1a9ec16eea6d4e141ec02b08f523ee
https://pubmed.ncbi.nlm.nih.gov/17701833
https://pubmed.ncbi.nlm.nih.gov/17701833
Autor:
M K, Bayliss, P J, Eddershaw
Publikováno v:
Ernst Schering Research Foundation workshop. (37)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9c708bed1fc5c49c63376c5a91b49e5
https://pubmed.ncbi.nlm.nih.gov/11975201
https://pubmed.ncbi.nlm.nih.gov/11975201