Zobrazeno 1 - 10 of 21 pro vyhledávání: '"M. John Rogers"'
1
Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent
Autor: James H. McKerrow, Sharon L. Reed, Robin Bricker-Ford, Edmund V. Capparelli, M. John Rogers
Publikováno v: Antimicrobial agents and chemotherapy, vol 61, iss 1
Capparelli, EV; Bricker-Ford, R; Rogers, MJ; McKerrow, JH; & Reed, SL. (2017). Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61(1). doi: 10.1128/AAC.01947-16. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/1cw9h5fc
Under an NIH priority to identify new drugs to treat class B parasitic agents, we performed high-throughput screens, which identified the activity of auranofin (Ridaura) against Entamoeba histolytica and Giardia intestinalis , major causes of water-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2801d37210a600d5389b45a8b31ad5b1
https://escholarship.org/uc/item/1cw9h5fc
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2
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
Autor: Rosemary Rochford, Kristina S. Wickham, Xavier C. Ding, David A. Fidock, Margaret A. Phillips, Thomas Rueckle, Sandra March, Brice Campo, Anna Marie Zeeman, Andrea Ruecker, Iñigo Angulo-Barturen, Xiaoyi Deng, Sergio Wittlin, Michael J. Delves, Farah El Mazouni, Susan A. Charman, Diana R. Tomchick, Laura Maria Sanz Alonso, Jacqueline W. Njoroge, Robert E. Sinden, Jeremy N. Burrows, Ian Bathhurst, Anthony Dayan, Lalitha V. Iyer, Trevor Laird, Koen J. Dechering, Caroline L. Ng, Sandra Duffy, Janet Gahagen, Jon C. Mirsalis, M. John Rogers, Kennan C. Marsh, Yanbin Lao, Pradipsinh K. Rathod, James B. Louttit, Santiago Ferrer Bazaga, Julie Lotharius, Yi Cui, Sreekanth Kokkonda, Francisco Javier Gamo Benito, Arun Sridhar, John H. White, María Santos Martínez, Maria J. Lafuente-Monasterio, María Belén Jiménez-Díaz, John N. Haselden, Sangeeta N. Bhatia, Didier Leroy, Robert W. Sauerwein, Clemens H. M. Kocken, Vicky M. Avery, Ed Riccio, Karen L. White
Publikováno v: Science Translational Medicine, 7, 296, pp. 296ra111
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
PMC
Science Translational Medicine, 7, 296ra111
Malaria is one of the most significant causes of childhood mortality, but disease control efforts are threatened by resistance of the Plasmodium parasite to current therapies. Continued progress in combating malaria requires development of new, easy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fcc77c46ef071db2bb33bf845ab1ab
https://doi.org/10.1126/scitranslmed.aaa6645
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3
Parallel Synthesis of Potent, Pyrazole-Based Inhibitors of Helicobacter pylori Dihydroorotate Dehydrogenase
Autor: George L. Trainor, Andrew P. Combs, Karen Amsler, Dong Liang Zhan, Andrew M. Stern, Robert A. Copeland, Tasir Shamsul Haque, Christine F. Sizemore, Lisa D. Ecret, Lisa M. Kopcho, Seifu Tadesse, Andrew M. Slee, Frank W. Hobbs, M. John Rogers, Jovita Marcinkeviciene
Publikováno v: Journal of Medicinal Chemistry. 45:4669-4678
The identification of several potent pyrazole-based inhibitors of bacterial dihydroorotate dehydrogenase (DHODase) via a directed parallel synthetic approach is described below. The initial pyrazole-containing lead compounds were optimized for potenc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039f4c4515594fb0da094487fc62ca17
https://doi.org/10.1021/jm020112w
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4
Recognition in the Glutamine tRNA System: from Structure to Function
Autor: Dieter Söll, M. John Rogers, Joyce M. Sherman
Publikováno v: tRNA
The ability of aminoacyl-tRNA synthetases (aaRS) to faithfully recognize both their amino acid and tRNA substrates is essential for accurate protein synthesis. This chapter focuses on the recognition of tRNA by Escherichia coli glutaminyl-tRNA synthe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a26686d99e47a6b11e6e4a4aa7abe8f5
https://doi.org/10.1128/9781555818333.ch19
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6
Helicobacter pylori-selective Antibacterials Based on Inhibition of Pyrimidine Biosynthesis
Autor: Karen A. Amsler, Lisa M. Kopcho, Seifu Tadesse, Tasir Shamsul Haque, Jovita Marcinkeviciene, Kathy Wang, Robert A. Copeland, Andrew M. Slee, M. John Rogers, Lori Foster, Wenjun Jiang, George L. Trainor, Andrew M. Stern, Andrew P. Combs, Frank W. Hobbs, Christine F. Sizemore, Lisa D. Ecret
Publikováno v: Journal of Biological Chemistry. 275:33373-33378
We report the discovery of a class of pyrazole-based compounds that are potent inhibitors of the dihydroorotate dehydrogenase of Helicobacter pylori but that do not inhibit the cognate enzymes from Gram-positive bacteria or humans. In culture these c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e329e713401a2c5dba755aa14c9d61
https://doi.org/10.1074/jbc.m004451200
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7
A Second Dihydroorotate Dehydrogenase (Type A) of the Human Pathogen Enterococcus faecalis: Expression, Purification, and Steady-State Kinetic Mechanism
Autor: Lisa M. Kopcho, Jovita Marcinkeviciene, M. John Rogers, Wenjun Jiang, Gregory Locke, Robert A. Copeland
Publikováno v: Archives of Biochemistry and Biophysics. 377:178-186
We report the identification, expression, and characterization of a second Dihydroorotate dehydrogenase (DHODase A) from the human pathogen Enterococcus faecalis. The enzyme consists of a polypeptide chain of 322 amino acids that shares 68% identity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e02deddf5d56b466caa78e1841216bb
https://doi.org/10.1006/abbi.2000.1769
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8
Chimeric rRNAs containing the GTPase centers of the developmentally regulated ribosomal rRNAs of Plasmodium falciparum are functionally distinct
Autor: M. John Rogers, Susan W. Liebman, Thomas F. McCutchan, Irina V. Velichutina
Publikováno v: RNA. 4:594-602
The human malaria parasite, Plasmodium falciparum, maintains at least two distinct types, A and S, of developmentally controlled ribosomal RNAs. To investigate specific functions associated with these rRNAs, we replaced the Saccharomyces cerevisiae G
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbcbdbe9b0487cf2b320fa47c130b50c
https://doi.org/10.1017/s1355838298980049
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9
Regulation and trafficking of three distinct 18 S ribosomal RNAs during development of the malaria parasite
Autor: Robin R. Gutell, Thomas F. McCutchan, Jun Li, Simon H. Damberger, Robert A. Wirtz, M. John Rogers, Jetsumon Sattabongkot, Jessica C. Kissinger
Publikováno v: Journal of Molecular Biology. 269:203-213
The human malaria parasite Plasmodium vivax has been shown to regulate the transcription of two distinct 18 RNAs during development. Here we show a third and distinctive type of ribosome that is present shortly after zygote formation, a transcription
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83428ce0aa12a6edd729e44b170c8210
https://doi.org/10.1006/jmbi.1997.1038
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10
Inhibition of Plasmodium falciparum Protein Synthesis
Autor: M. John Rogers, Glenn A. McConkey, Thomas F. McCutchan
Publikováno v: Journal of Biological Chemistry. 272:2046-2049
The human malaria parasite Plasmodium falciparum has two extrachromosomal DNAs associated with organelles whose function is unclear. Both genomes encode ribosomal RNAs (rRNAs) that are distinct from the nuclear-encoded rRNAs. Secondary structure anal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a416b02adf64c8e8641c2457442b4801
https://doi.org/10.1074/jbc.272.4.2046
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