Zobrazeno 1 - 10
of 129
pro vyhledávání: '"M. Jayne Lawrence"'
Autor:
Delaram Ahmadi, Katherine C. Thompson, Victoria García Sakai, Ralf Schweins, Martine Moulin, Michael Haertlein, Gernot A. Strohmeier, Harald Pichler, V. Trevor Forsyth, David J. Barlow, M. Jayne Lawrence, Fabrizia Foglia
Publikováno v:
Frontiers in Physics, Vol 10 (2022)
Quasi-elastic neutron scattering (QENS) and small angle neutron scattering (SANS), in combination with isotopic contrast variation, have been used to determine the structure and dynamics of three-component lipid membranes, in the form of vesicles, co
Externí odkaz:
https://doaj.org/article/fee38fd2cb2544db8225233244a8fdf8
Autor:
Lili Cui, Laila Kudsiova, Frederick Campbell, David J. Barlow, Helen C. Hailes, Alethea B. Tabor, M. Jayne Lawrence
Publikováno v:
Biomaterials Science. 11:3335-3353
Lipopolyplexes formulated from branched cationic peptides with cell receptor targeting sequences, DOTMA and DOPE, and plasmid DNA in the presence of saline form multilamellar nanoparticles with enhanced stability and transfection in serum.
Autor:
Alice Spadea, Mark Jackman, Lili Cui, Sara Pereira, M. Jayne Lawrence, Richard A. Campbell, Marianne Ashford
Publikováno v:
Spadea, A, Jackman, M, Cui, L, Pereira, S, Lawrence, M J, Campbell, R A & Ashford, M 2022, ' Nucleic Acid-Loaded Lipid Nanoparticle Interactions with Model Endosomal Membranes ', ACS applied materials & interfaces, vol. 14, no. 26, pp. 30371-30384 . https://doi.org/10.1021/acsami.2c06065
Lipid nanoparticles (LNPs) are important delivery systems for RNA-based therapeutics, yet the mechanism of their interaction with endosomal membranes remains unclear. Here, the interactions of nucleic acid-loaded LNPs that contain an ionizable lipid
Autor:
Javier Carrascosa-Tejedor, Andreas Santamaria, Andrea Tummino, Imre Varga, Marina Efstratiou, M. Jayne Lawrence, Armando Maestro, Richard A. Campbell
Publikováno v:
Carrascosa-Tejedor, J, Santamaria, A, Tummino, A, Varga, I, Efstratiou, M, Lawrence, M J, Maestro, A & Campbell, R A 2022, ' Polyelectrolyte/surfactant films: from 2D to 3D structural control ', Chemical Communications, vol. 58, no. 76 . https://doi.org/10.1039/D2CC03766A
Reversible control of the 3D structure of polyelectrolyte/surfactant films at the air/water interface is showcased. A recently discovered mechanism is exploited to form highly efficient, stable and biocompatible films by spreading aggregates composed
Publikováno v:
Pharmaceutics, Vol 12, Iss 9, p 864 (2020)
It is well-established that oil-in-water creams can be stabilised through the formation of lamellar liquid crystal structures in the continuous phase, achieved by adding (emulsifier) mixtures comprising surfactant(s) combined (of necessity) with one
Externí odkaz:
https://doaj.org/article/a92ddd2dc5734032a8467c9d5fbcabc5
Autor:
David J. Barlow, Orathai Loruthai, Ann E. Terry, Christian D. Lorenz, M. Jayne Lawrence, Robert M. Ziolek, Demi L. Pink
Publikováno v:
Journal of Colloid and Interface Science. 597:278-288
Liquid lipid nanoparticles (LLN) are oil-in-water nanoemulsions of great interest in the delivery of hydrophobic drug molecules. They consist of a surfactant shell and a liquid lipid core. The small size of LLNs makes them difficult to study, yet a d
Publikováno v:
Rhys, N H, Barlow, D, Lawrence, J & Lorenz, C D 2022, ' On the interactions of diols and DMPC monolayers ', Journal of Molecular Liquids, vol. 364, 119963 . https://doi.org/10.1016/j.molliq.2022.119963
Rhys, N H, Barlow, D J, Lawrence, M J & Lorenz, C D 2022, ' On the interactions of diols and DMPC monolayers ', JOURNAL OF MOLECULAR LIQUIDS, vol. 364, 119963 . https://doi.org/10.1016/j.molliq.2022.119963
Rhys, N H, Barlow, D J, Lawrence, M J & Lorenz, C D 2022, ' On the interactions of diols and DMPC monolayers ', JOURNAL OF MOLECULAR LIQUIDS, vol. 364, 119963 . https://doi.org/10.1016/j.molliq.2022.119963
The interactions of lipid molecules with various solvent molecules is of utmost importance in the formulation of various drug delivery and personal care formulations. In this manuscript, a series of all-atom molecular dynamics simulations were used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42947ad2e5b7cea451db857372fcade4
https://doi.org/10.1016/j.molliq.2022.119963
https://doi.org/10.1016/j.molliq.2022.119963
Autor:
Nadim Akhtar, Marianne B. Ashford, Louisa Beer, Alex Bowes, Tony Bristow, Anders Broo, David Buttar, Steve Coombes, Rebecca Cross, Emma Eriksson, Jean-Baptiste Guilbaud, Stephen W. Holman, Leslie P. Hughes, Mark Jackman, M. Jayne Lawrence, Jessica Lee, Weimin Li, Rebecca Linke, Najet Mahmoudi, Marc McCormick, Bryce MacMillan, Ben Newling, Maryann Ngeny, Claire Patterson, Andy Poulton, Andrew Ray, Natalie Sanderson, Silvia Sonzini, Yayan Tang, Kevin E. Treacher, Dave Whittaker, Stephen Wren
Publikováno v:
Journal of pharmaceutical sciences.
The recent emergence of drug-dendrimer conjugates within pharmaceutical industry research and development introduces a range of challenges for analytical and measurement science. These molecules are very high molecular weight (100-200kDa) with a sign
Autor:
Hrachya Ishkhanyan, Robert M. Ziolek, David J. Barlow, M. Jayne Lawrence, Armen H. Poghosyan, Christian D. Lorenz
Publikováno v:
Ishkhanyan, H, Ziolek, R M, Barlow, D, Lawrence, J, Poghosyan, A H & Lorenz, C D 2022, ' NSAID solubilisation promotes morphological transitions in Triton X-114 surfactant micelles ', Journal of Molecular Liquids, vol. 356, 119050 . https://doi.org/10.1016/j.molliq.2022.119050
Ishkhanyan, H, Ziolek, R M, Barlow, D J, Jayne Lawrence, M, Poghosyan, A H & Lorenz, C D 2022, ' NSAID Solubilisation Promotes Morphological Transitions in Triton X-114 Surfactant Micelles ', JOURNAL OF MOLECULAR LIQUIDS, vol. 356, 119050 . https://doi.org/10.1016/j.molliq.2022.119050
Ishkhanyan, H, Ziolek, R M, Barlow, D J, Jayne Lawrence, M, Poghosyan, A H & Lorenz, C D 2022, ' NSAID Solubilisation Promotes Morphological Transitions in Triton X-114 Surfactant Micelles ', JOURNAL OF MOLECULAR LIQUIDS, vol. 356, 119050 . https://doi.org/10.1016/j.molliq.2022.119050
The structural properties of micelles formed by the non-ionic surfactant, Triton X-114 (TX-114), were investigated using all-atom molecular dynamics (MD) simulations. Additionally, we investigated the effect of the solubilisation of the sodium salts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32dd8c1eeca21d4e5fc38e09b8cd3fb2
https://www.research.manchester.ac.uk/portal/en/publications/nsaid-solubilisation-promotes-morphological-transitions-in-triton-x114-surfactant-micelles(6ba18858-8eb1-4796-891d-843741e0cdab).html
https://www.research.manchester.ac.uk/portal/en/publications/nsaid-solubilisation-promotes-morphological-transitions-in-triton-x114-surfactant-micelles(6ba18858-8eb1-4796-891d-843741e0cdab).html
Autor:
Charlotte M. Beddoes, Gert S. Gooris, David J. Barlow, M. Jayne Lawrence, Robert M. Dalgliesh, Marc Malfois, Bruno Demé, Joke A. Bouwstra
Publikováno v:
'Biochimica et Biophysica Acta (BBA)-Biomembranes ', vol: 1864, pages: 183886-1-183886-9 (2022)
BBA-Biomembranes, 1864(6)
Beddoes, C M, Gooris, G S, Barlow, D, Lawrence, J, Dalgliesh, R M, Malfois, M, Deme, B & Bouwstra, J A 2022, ' The importance of ceramide headgroup for lipid localisation in skin lipid models ', Biochimica et Biophysica Acta-Biomembranes, vol. 1864, no. 6, 183886 . https://doi.org/10.1016/j.bbamem.2022.183886
BBA-Biomembranes, 1864(6)
Beddoes, C M, Gooris, G S, Barlow, D, Lawrence, J, Dalgliesh, R M, Malfois, M, Deme, B & Bouwstra, J A 2022, ' The importance of ceramide headgroup for lipid localisation in skin lipid models ', Biochimica et Biophysica Acta-Biomembranes, vol. 1864, no. 6, 183886 . https://doi.org/10.1016/j.bbamem.2022.183886
The stratum corneum's lipid matrix is a critical for the skin's barrier function and is primarily composed of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs). The lipids form a long periodicity phase (LPP), a unique trilayer unit cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc1863f9286fa88a34a013be86d564e
https://hdl.handle.net/1887/3281234
https://hdl.handle.net/1887/3281234