Zobrazeno 1 - 10
of 13
pro vyhledávání: '"M. Javad Wahadat"'
Autor:
P. Martijn Kolijn, Erika Huijser, M. Javad Wahadat, Cornelia G. van Helden-Meeuwsen, Paul L. A. van Daele, Zana Brkic, Jos Rijntjes, Konnie M. Hebeda, Patricia J. T. A. Groenen, Marjan A. Versnel, Rogier M. Thurlings, Anton W. Langerak
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionActivated B cells play a key role in the pathogenesis of primary Sjögren’s syndrome (pSS) through the production of autoantibodies and the development of ectopic germinal centers in the salivary glands and other affected sites. Around
Externí odkaz:
https://doaj.org/article/f8ad4e01c67f479783c7d60574855f40
Autor:
Eduardo Gomez-Bañuelos, M. Javad Wahadat, Jessica Li, Merlin Paz, Brendan Antiochos, Alessandra Ida Celia, Victoria Andrade, Dylan P. Ferris, Daniel W. Goldman, Erika Darrah, Michelle Petri, Felipe Andrade
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
The origin and mechanisms of autoantigen generation in systemic lupus erythematosus (SLE) are poorly understood. Here, we identified SLE neutrophils activated in vivo by IFN as a prominent source of Ro52, also known as tripartite motif–containing p
Externí odkaz:
https://doaj.org/article/f1b228d8d0914f8591299716f70f3efc
Autor:
Erika Huijser, Cornelia G. van Helden-Meeuwsen, Dwin G. B. Grashof, Jessica R. Tarn, Zana Brkic, Josje M. A. Huisman, M. Javad Wahadat, Harmen J. G. van de Werken, Ana P. Lopes, Joel A. G. van Roon, Paul L. A. van Daele, Sylvia Kamphuis, Wan-Fai Ng, Siroon Bekkering, Leo A. B. Joosten, Willem A. Dik, Marjan A. Versnel
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundTrained immunity – or innate immune memory – can be described as the long-term reprogramming of innate immune cells towards a hyperresponsive state which involves intracellular metabolic changes. Trained immunity has been linked to athe
Externí odkaz:
https://doaj.org/article/72f7b5e73ccf4457a9a39a2512306f2e
Autor:
M. Javad Wahadat, Iris L. A. Bodewes, Naomi I. Maria, Cornelia G. van Helden-Meeuwsen, Annette van Dijk-Hummelman, Eline C. Steenwijk, Sylvia Kamphuis, Marjan A. Versnel
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-8 (2018)
Abstract Background Childhood-onset systemic lupus erythematosus (cSLE) is an incurable multi-systemic autoimmune disease. Interferon type I (IFN-I) plays a pivotal role in the pathogenesis of SLE. The objective of this study was to assess the preval
Externí odkaz:
https://doaj.org/article/7096428082454de8b5f22d855283ded1
Autor:
M Javad Wahadat, Hongchao Qi, Cornelia G van Helden-Meeuwsen, Erika Huijser, Lotte van den Berg, Annette van Dijk-Hummelman, Jens C Göpfert, Anne Heine, Marleen Verkaaik, Marco W J Schreurs, Willem A Dik, Sylvia Kamphuis, Marjan A Versnel
Publikováno v:
Rheumatology. Oxford University Press
Objective To study the association of serum IFNα2 levels measured by ultrasensitive single-molecule array (Simoa) and the IFN-I gene signature (IGS) with disease activity and determine whether these assays can mark disease activity states in a longi
Autor:
M Javad Wahadat, Dieneke Schonenberg-Meinema, Cornelia G van Helden-Meeuwsen, Sander J van Tilburg, Noortje Groot, Ellen J H Schatorjé, Esther P A H Hoppenreijs, Petra C E Hissink Muller, Danielle M C Brinkman, Denis Dvorak, Marleen Verkaaik, J Merlijn van den Berg, Kateřina Bouchalova, Sylvia Kamphuis, Marjan A Versnel
Publikováno v:
Rheumatology (Oxford, England), 61(11), 4344-4354. Oxford University Press
Rheumatology, 61, 11, pp. 4344-4354
Rheumatology, 61(11), 4344-4354. OXFORD UNIV PRESS
Rheumatology, 61, 4344-4354
Rheumatology, 61, 11, pp. 4344-4354
Rheumatology, 61(11), 4344-4354. OXFORD UNIV PRESS
Rheumatology, 61, 4344-4354
Objectives Clinical phenotyping and predicting treatment responses in SLE patients is challenging. Extensive blood transcriptional profiling has identified various gene modules that are promising for stratification of SLE patients. We aimed to transl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d9c34f4a25691cef9c1fe747ffb6cf
https://hdl.handle.net/1887/3575935
https://hdl.handle.net/1887/3575935
Autor:
I. Bodewes, M. Versnel, M. Javad Wahadat, Sylvia Kamphuis, Erika Huijser, Noortje Groot, C.G. van Helden-Meeuwsen
Publikováno v:
Poster Presentations.
Background: Systemic lupus erythematosus (SLE) is a heterogeneous, lifelong autoimmune disease, with a more severe phenotype in children compared to adult-onset SLE [1]. To date, approved drugs are by far not effective enough and have significant sid
Autor:
Jan A. M. van Laar, Marjan A. Versnel, Virgil A. S. H. Dalm, M. Javad Wahadat, C.G. van Helden-Meeuwsen, Noortje Groot, P. Martin van Hagen, Sylvia Kamphuis, Paul L A van Daele, Iris L A Bodewes, Erika Huijser, Marco W.J. Schreurs, Matti Waris
Publikováno v:
Saturday, 15 June 2019.
Background Activation of the type I interferon (IFN) system has been found in large subsets of patients with systemic autoimmune diseases. This is usually assessed with a laborious quantification of IFN-stimulated genes. An easier and cheap biomarker
Akademický článek
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Autor:
Marjan A. Versnel, M. Javad Wahadat, Eline C. Steenwijk, Annette van Dijk-Hummelman, Iris L A Bodewes, Naomi I Maria, Sylvia Kamphuis, Cornelia G van Helden-Meeuwsen
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-8 (2018)
Arthritis Research & Therapy, 20:4. BioMed Central Ltd.
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-8 (2018)
Arthritis Research & Therapy, 20:4. BioMed Central Ltd.
Background Childhood-onset systemic lupus erythematosus (cSLE) is an incurable multi-systemic autoimmune disease. Interferon type I (IFN-I) plays a pivotal role in the pathogenesis of SLE. The objective of this study was to assess the prevalence of t