Zobrazeno 1 - 10
of 280
pro vyhledávání: '"M. Javad Aman"'
Autor:
Kevin E. Ramos, Nisreen M. A. Okba, Jessica Tan, Pooja Bandawane, Philip S. Meade, Madhumathi Loganathan, Benjamin Francis, Sergey Shulenin, Frederick W. Holtsberg, M. Javad Aman, Meagan McMahon, Florian Krammer, Jonathan R. Lai
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Monoclonal antibodies (mAbs) are an attractive therapeutic platform for the prevention and treatment of influenza virus infection. There are two major glycoproteins on the influenza virion surface: hemagglutinin (HA), which is responsible fo
Externí odkaz:
https://doaj.org/article/e51458b0b781478a9593e39a21359443
Autor:
Ariel S Wirchnianski, Elisabeth K Nyakatura, Andrew S Herbert, Ana I Kuehne, Shawn A Abbasi, Catalina Florez, Nadia Storm, Lindsay G A McKay, Leandrew Dailey, Erin Kuang, Dafna M Abelson, Anna Z Wec, Srinjoy Chakraborti, Frederick W Holtsberg, Sergey Shulenin, Zachary A Bornholdt, M Javad Aman, Anna N Honko, Anthony Griffiths, John M Dye, Kartik Chandran, Jonathan R Lai
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012134 (2024)
Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as well as the capacity to induce immune-mediated virus clearance. Their activities can be furth
Externí odkaz:
https://doaj.org/article/2302156227ee41508fe68701e955e1ae
Autor:
Yu Wang, Ipsita Mukherjee, Arundhathi Venkatasubramaniam, Dustin Dikeman, Nicholas Orlando, Jing Zhang, Roger Ortines, Mark Mednikov, Shardulendra P. Sherchand, Tulasikumari Kanipakala, Thao Le, Sanjay Shukla, Mark Ketner, Rajan P. Adhikari, Hatice Karauzum, M. Javad Aman, Nathan K. Archer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs) in the U.S. as well as more serious invasive diseases, including bacteremia, sepsis, endocarditis, surgical site infections, osteomyelitis, and pneumonia. These inf
Externí odkaz:
https://doaj.org/article/9e8670e1737d41c3b9440e011a2c6162
Autor:
Tania Wong Fok Lung, Liana C. Chan, Alice Prince, Michael R. Yeaman, Nathan K. Archer, M. Javad Aman, Richard A. Proctor
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Despite meritorious attempts, a S. aureus vaccine that prevents infection or mitigates severity has not yet achieved efficacy endpoints in prospective, randomized clinical trials. This experience underscores the complexity of host-S. aureus interacti
Externí odkaz:
https://doaj.org/article/bc573c1aa8194125a8ccfdafc9362db9
Autor:
Shweta Kailasan, Ravi Kant, Madeleine Noonan-Shueh, Tulasikumari Kanipakala, Grant Liao, Sergey Shulenin, Daisy W. Leung, Richard A. Alm, Rajan P. Adhikari, Gaya K. Amarasinghe, Michael L. Gross, M. Javad Aman
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Staphylococcus aureus carries an exceptional repertoire of virulence factors that aid in immune evasion. Previous single-target approaches for S. aureus-specific vaccines and monoclonal antibodies (mAbs) have failed in clinical trials due to the mult
Externí odkaz:
https://doaj.org/article/536d0a35d34246f88a85754222c857ae
Autor:
Krista Meserve, Abraham J. Qavi, M. Javad Aman, Hong Vu, Larry Zeitlin, John M. Dye, Jeffrey W. Froude, Daisy W. Leung, Lan Yang, Frederick W. Holtsberg, Gaya K. Amarasinghe, Ryan C. Bailey
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101719- (2022)
Summary: This protocol describes the use of silicon photonic microring resonator sensors for detection of Ebola virus (EBOV) and Sudan virus (SUDV) soluble glycoprotein (sGP). This protocol encompasses biosensor functionalization of silicon microring
Externí odkaz:
https://doaj.org/article/e9bbcc7f59114f908957058b53e324a5
Autor:
Tarcisio Brignoli, Edward Douglas, Seána Duggan, Olayemi Grace Fagunloye, Rajan Adhikari, M. Javad Aman, Ruth C. Massey
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 4 (2022)
ABSTRACT A major feature of the pathogenicity of Staphylococcus aureus is its ability to secrete cytolytic toxins. This process involves the translocation of the toxins from the cytoplasm through the bacterial membrane and the cell wall to the extern
Externí odkaz:
https://doaj.org/article/42777fa10e2d4ec1ba1fadeec16444b3
Autor:
Shardulendra Prasad Sherchand, Rajan P. Adhikari, Gowrishankar Muthukrishnan, Tulasikumari Kanipakala, John R. Owen, Chao Xie, M. Javad Aman, Richard A. Proctor, Edward M. Schwarz, Stephen L. Kates
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Staphylococcus aureus osteomyelitis remains a very challenging condition; recent clinical studies have shown infection control rates following surgery/antibiotics to be ~60%. Additionally, prior efforts to produce an effective S. aureus vaccine have
Externí odkaz:
https://doaj.org/article/86befead12a24ee4bec39e7017d85dbf
Autor:
Xiaobing Han, Roger Ortines, Ipsita Mukherjee, Tulasikumari Kanipakala, Thomas Kort, Shardulendra P. Sherchand, Grant Liao, Mark Mednikov, Agnes L. Chenine, M. Javad Aman, Cory L. Nykiforuk, Rajan P. Adhikari
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Staphylococcus aureus has been acquiring multiple drug resistance and has evolved into superbugs such as Methicillin/Vancomycin-resistant S. aureus (MRSA/VRSA) and, consequently, is a major cause of nosocomial and community infections associated with
Externí odkaz:
https://doaj.org/article/8ed38ad2e8f142c89e8bcb9df02022af
Autor:
Tom Z. Yuan, Pankaj Garg, Linya Wang, Jordan R. Willis, Eric Kwan, Ana G Lujan Hernandez, Emily Tuscano, Emily N. Sever, Erica Keane, Cinque Soto, Eric M. Mucker, Mallorie E. Fouch, Edgar Davidson, Benjamin J. Doranz, Shweta Kailasan, M. Javad Aman, Haoyang Li, Jay W. Hooper, Erica Ollmann Saphire, James E. Crowe, Qiang Liu, Fumiko Axelrod, Aaron K. Sato
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Coronavirus disease 2019 (COVID-19) is an evolving global public health crisis in need of therapeutic options. Passive immunization of monoclonal antibodies (mAbs) represents a promising therapeutic strategy capable of conferring immediate protection
Externí odkaz:
https://doaj.org/article/b6c1901170674ee7807acd867a09110b