The N terminus of α-ENaC mediates ENaC cleavage and activation by furin

Autor: Pradeep Kota, Yan L. Dang, Martina Gentzsch, Richard C. Boucher, M. Jackson Stutts

Publikováno v: The Journal of General Physiology

A natural splice deletion of rat α-ENaC was previously reported to produce reduced ENaC current that was not attributable to reduced surface expression. Kota et al. show that this ENaC variant resists furin cleavage, implicating α-ENaC residues 34�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5bce26e0bde5883a055547d5bfa5c0
http://europepmc.org/articles/PMC6080898

ATP as Neurally Released Modulator of Human Airway Ion Transport

Autor: Michael R. Knowles, Eduardo R. Lazarowski, M. Jackson Stutts, S. J. Mason, Richard C. Boucher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9811392c73cfe20e4f11d1241b40782c
https://doi.org/10.1201/9780203745915-21

Inhibition of Protease–Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways

Autor: Siobhan M. Hendrick, Brian J. Harvey, Robert Hamilton, Timothy Ferguson, Vinciane Saint-Criq, M. Jackson Stutts, J. Stuart Elborn, S. Lorraine Martin, Brian Walker, James Reihill

Publikováno v: Reihill, J A, Walker, B, Hamilton, R A, Ferguson, T E G, Elborn, J S, Stutts, M J, Harvey, B J, Saint-Criq, V, Hendrick, S M & Martin, S L 2016, ' Inhibition of Protease–Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways ', American Journal of Respiratory and Critical Care Medicine, vol. 194, no. 6, pp. 701-710 . https://doi.org/10.1164/rccm.201511-2216OC
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2016, 194 (6), pp.701-710. ⟨10.1164/rccm.201511-2216OC⟩

RATIONALE:In cystic fibrosis (CF) a reduction in airway surface liquid (ASL) height compromises mucociliary clearance, favoring mucus plugging and chronic bacterial infection. Inhibitors of the epithelial sodium channel (ENaC) have therapeutic potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cbf09671ff05a2839724191735a4e7
https://pure.qub.ac.uk/en/publications/inhibition-of-proteaseepithelial-sodium-channel-signaling-improves-mucociliary-function-in-cystic-fibrosis-airways(e8995c59-71df-44f5-9313-ffa3d7761878).html

Energetic and Structural Basis for Activation of the Epithelial Sodium Channel by Matriptase

Autor: Martina Gentzsch, Hong Dang, Agustin Garcia-Caballero, M. Jackson Stutts, Pradeep Kota, Nikolay V. Dokholyan

Publikováno v: Biochemistry. 51:3460-3469

Limited proteolysis, accomplished by endopeptidases, is a ubiquitous phenomenon underlying the regulation and activation of many enzymes, receptors and other proteins synthesized as inactive precursors. Serine proteases are one of the largest and con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebaf9fe55d22893ae11c1aa5a55121f8
https://doi.org/10.1021/bi2014773

Activation of the Epithelial Sodium Channel (ENaC) by Serine Proteases

Autor: Bernard C. Rossier, M. Jackson Stutts

Publikováno v: Annual Review of Physiology. 71:361-379

The study of human monogenic diseases [pseudohypoaldosteronism type 1 (PHA-1) and Liddle's syndrome] as well as mouse models mimicking the salt-losing syndrome (PHA-1) or salt-sensitive hypertension (Liddle's syndrome) have established the epithelial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204883daa5d851f0d7ec4f554519a74e
https://doi.org/10.1146/annurev.physiol.010908.163108