Zobrazeno 1 - 10
of 203
pro vyhledávání: '"M. JIGGINS"'
Autor:
Alexandre B. Leitão, Ramesh Arunkumar, Jonathan P. Day, Nancy Hanna, Aarathi Devi, Matthew P. Hayes, Francis M. Jiggins
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Innate immune responses can be activated by pathogen-associated molecular patterns (PAMPs), danger signals released by damaged tissues, or the absence of self-molecules that inhibit immunity. As PAMPs are typically conserved acros
Externí odkaz:
https://doaj.org/article/de39d1abcbb54e31971b339b22f03e6a
Autor:
Shuyu Olivia Zhou, Ramesh Arunkumar, Amina Irfan, Shuai Dominique Ding, Alexandre B Leitão, Francis M Jiggins
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011729 (2024)
Both constitutive and inducible immune mechanisms are employed by hosts for defense against infection. Constitutive immunity allows for a faster response, but it comes with an associated cost that is always present. This trade-off between speed and f
Externí odkaz:
https://doaj.org/article/a8971a707b9c48c3b49d8c2b779cbcff
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Wolbachia is a common endosymbiont that can protect insects against viral pathogens. However, whether the antiviral effects of Wolbachia have a significant effect on fitness remains unclear. We have investigated the interaction between Droso
Externí odkaz:
https://doaj.org/article/07f687d21c774616a59a606801d8784e
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Parasites reduce the fitness of their hosts, and different causes of this damage have fundamentally different consequences for the evolution of immune defences. Damage to the host may result from the parasite directly harming its host, often due to t
Externí odkaz:
https://doaj.org/article/ca842891ed0a4d0abdcd80ded14960f0
Autor:
Perran A Ross, Samia Elfekih, Sophie Collier, Melissa J Klein, Su Shyan Lee, Michael Dunn, Sarah Jackson, Yexin Zhang, Jason K Axford, Xinyue Gu, Jessica L Home, Majed S Nassar, Prasad N Paradkar, Essam A Tawfik, Francis M Jiggins, Abdulaziz M Almalik, Mohamed B Al-Fageeh, Ary A Hoffmann
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011117 (2023)
Aedes aegypti mosquitoes carrying self-spreading, virus-blocking Wolbachia bacteria are being deployed to suppress dengue transmission. However, there are challenges in applying this technology in extreme environments. We introduced two Wolbachia str
Externí odkaz:
https://doaj.org/article/ee96bdeb1b3e41a090721b41c0ac7b5a
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
Cogni et al. report a protective effect of Wolbachia on viral infection of a natural Drosophila population through metagenomics sequencing of the virome. This study provides new evidence showing that Wolbachia confers viral resistance in natural popu
Externí odkaz:
https://doaj.org/article/84cb926a8eac406ba1ea6c4538ab324e
Autor:
Shuai Dominique Ding, Alexandre B Leitão, Jonathan P Day, Ramesh Arunkumar, Morgan Phillips, Shuyu Olivia Zhou, Francis M Jiggins
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010453 (2022)
When an animal is infected, the expression of a large suite of genes is changed, resulting in an immune response that can defend the host. Despite much evidence that the sequence of proteins in the immune system can evolve rapidly, the evolution of g
Externí odkaz:
https://doaj.org/article/a260983ef01f47b39cdd6af40ac8004c
Autor:
Matsapume Detcharoen, Wolfgang Arthofer, Francis M. Jiggins, Florian M. Steiner, Birgit C. Schlick‐Steiner
Publikováno v:
Ecology and Evolution, Vol 10, Iss 10, Pp 4457-4470 (2020)
Abstract Wolbachia, intracellular endosymbionts, are estimated to infect about half of all arthropod species. These bacteria manipulate their hosts in various ways for their maximum benefits. The rising global temperature may accelerate species migra
Externí odkaz:
https://doaj.org/article/7bd55828272249279394d06e70e7447a
Autor:
Alexandre B Leitão, Ramesh Arunkumar, Jonathan P Day, Emma M Geldman, Ismaël Morin-Poulard, Michèle Crozatier, Francis M Jiggins
Publikováno v:
eLife, Vol 9 (2020)
Organisms rely on inducible and constitutive immune defences to combat infection. Constitutive immunity enables a rapid response to infection but may carry a cost for uninfected individuals, leading to the prediction that it will be favoured when inf
Externí odkaz:
https://doaj.org/article/b00a684d2c534fdbbc21d8b55e2bbd35
Autor:
Samuel H Lewis, Laura Ross, Stevie A Bain, Eleni Pahita, Stephen A Smith, Richard Cordaux, Eric A Miska, Boris Lenhard, Francis M Jiggins, Peter Sarkies
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008864 (2020)
Cytosine methylation is an ancient epigenetic modification yet its function and extent within genomes is highly variable across eukaryotes. In mammals, methylation controls transposable elements and regulates the promoters of genes. In insects, DNA m
Externí odkaz:
https://doaj.org/article/7951cbc5c39449c3908f02bb355e6640