Výsledky vyhledávání - "M. J. W. Ijsseldijk"

Role of ADP Receptor P2Y 12 in Platelet Adhesion and Thrombus Formation in Flowing Blood

Autor: Gijsbert van Willigen, Alan T. Nurden, Jasper A. Remijn, Jan J. Sixma, Ya-Ping Wu, M. J. W. Ijsseldijk, Philip G. de Groot, Paquita Nurden, Ellen H. Jeninga

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 22:686-691

ADP plays a central role in regulating platelet function. It induces platelet aggregation via the activation of 2 major ADP receptors, P2Y 1 and P2Y 12 . We have investigated the role of P2Y 12 in platelet adhesion and thrombus formation under physio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3489e9abbe7ff88318d2c14c64c31abe
https://doi.org/10.1161/01.atv.0000012805.49079.23

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Adhesive Domains in the Collagen III Fragment α1(III)CB4 that Support α2β1- and von Willebrand Factor-mediated Platelet Adhesion under Flow Conditions

Autor: C.G. Knight, Verkleij Mw, M. J. W. Ijsseldijk, G.J. Heijnen-Snyder, Laurence F. Morton, J. J. Sixma, de Groot Pg, Huizinga Eg, Mike Barnes

Publikováno v: Thrombosis and Haemostasis. 82:1137-1144

Seven overlapping peptides derived from the bovine alpha1(III)CB4 fragment of collagen III support static platelet adhesion, and an integrin alpha2beta1-recognition site has been assigned within this fragment to residues 522-528 of the collagen alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddb7ba6131c12ddcc191919f7b793e12
https://doi.org/10.1055/s-0037-1614343

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Recombinant vWF Type 2A Mutants R834Q and R834W Show a Defect in Mediating Platelet Adhesion to Collagen, Independent of Enhanced Sensitivity to a Plasma Protease

Autor: H. Lankhof, Tom Vink, C. Damas, Madelon Bracke, M. E. Schiphorst, P. G. De Groot, M. J. W. Ijsseldijk, J. J. Sixma, Miha Furlan

Publikováno v: Thrombosis and Haemostasis. 81:976-983

SummaryType 2A von Willebrand Disease (vWD) is characterized by the absence of high molecular weight von Willebrand factor (vWF) multimers in plasma which is caused by enhanced extracellular proteolysis or defective intracellular transport. We identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::197fb8345fd96421c62e38fa6ce8d4be
https://doi.org/10.1055/s-0037-1614609

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Functional Studies on Platelet Adhesion With Recombinant von Willebrand Factor Type 2B Mutants R543Q and R543W Under Conditions of Flow

Autor: Madelon Bracke, C. Damas, Marion E. Schiphorst, M. J. W. Ijsseldijk, Philip G. de Groot, Tom Vink, Jan J. Sixma, Hanneke Lankhof

Publikováno v: Blood. 89:2766-2772

Type 2B von Willebrand disease (vWD) is characterized by the absence of the very high molecular weight von Willebrand factor (vWF ) multimers from plasma, which is caused by spontaneous binding to platelet receptor glycoprotein Ib (GPIb). We studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b70dfcbe537ab4ec7811bddc3616ea5
https://doi.org/10.1182/blood.v89.8.2766

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von Willebrand Factor without the A2 Domain Is Resistant to Proteolysis

Autor: C. Damas, H. Lankhof, de Groot Pg, Han-Mou Tsai, Miha Furlan, Madelon Bracke, Jan J. Sixma, M. E. Schiphorst, M. J. W. Ijsseldijk, Tom Vink

Publikováno v: Thrombosis and Haemostasis. 77:1008-1013

Summaryvon Willebrand factor (vWF) is a complex multimeric plasma glycoprotein, that plays a critical role in the mediation of platelet adhesion to the damaged vascular wall, and functions as a carrier protein for factor VIII. vWF has a domain struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f92c1ca78f152192f0ee34a81c34900
https://doi.org/10.1055/s-0038-1656094

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A3 Domain Is Essential for Interaction of von Willebrand Factor with Collagen Type III

Autor: M. E. Schiphorst, M. Van Hoeij, Madelon Bracke, H. Lankhof, P. G. De Groot, Jan J. Sixma, M. J. W. Ijsseldijk, Tom Vink, Ya Ping Wu

Publikováno v: Thrombosis and Haemostasis. 75:950-958

von Willebrand factor (vWF) mediates platelet adhesion at sites of vascular damage. It acts as a bridge between receptors on platelets and collagens present in the connective tissue. Two collagen binding sites have been identified on the A1 and A3 do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d94bb1e27e1fedd4284d7c743aca637
https://doi.org/10.1055/s-0038-1650400

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Platelet adhesion to fibronectin in flow: the importance of von Willebrand factor and glycoprotein Ib

Autor: Harry F. G. Heijnen, E Orlando, S. Beumer, M. J. W. Ijsseldijk, P. G. De Groot, J. J. Sixma

Publikováno v: Blood. 86:3452-3460

We describe glycoprotein (GP) Ib as a mediator of adhesion to fibronectin, specifically in flow. A monoclonal antibody (MoAb) directed to the von Willebrand factor (vWF)-binding site on this receptor or the absence of this receptor on the platelet me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35cfd4ec61e9f62556b67c1b8e029681
https://doi.org/10.1182/blood.v86.9.3452.bloodjournal8693452

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Platelet adhesion to fibronectin in flow: dependence on surface concentration and shear rate, role of platelet membrane glycoproteins GP IIb/IIIa and VLA-5, and inhibition by heparin

Autor: S. Beumer, P. G. De Groot, J. J. Sixma, M. J. W. Ijsseldijk

Publikováno v: Blood. 84:3724-3733

Platelet adhesion to purified surface-immobilized fibronectin under flow conditions was investigated. Fibronectin was found to support attachment and spreading of platelets. The extent of platelet spreading depended on the amount of immobilized fibro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdf21fc821f132bf79f07c9666fb7989
https://doi.org/10.1182/blood.v84.11.3724.bloodjournal84113724

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The Platelet Adhesion Capacity to Subendothelial Matrix and Collagen in a Flow Model during Storage of Platelet Concentrates for 7 Days

Autor: M. N. Boomgaard, C. W. N. Gouwerok, P. G. De Groot, Christa H. E. Homburg, Dirk de Korte, M. J. W. Ijsseldijk

Publikováno v: Thrombosis and Haemostasis. 72:611-616

SummaryThe influence of storage of platelet concentrates (PC) on the adhesion capacity of platelets was studied. Twenty-four PC, 12 prepared by the buffy coat (BC) method and 12 by the platelet-rich plasma (PRP) method, were stored for 7 days at room

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64089328af651c463dc1e244bb8fecc1
https://doi.org/10.1055/s-0038-1648923

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Type I von Willebrand disease, subtype ‘platelet low’: decreased platelet adhesion can be explained by low synthesis of von Willebrand factor in endothelial cells

Autor: Jan J. Sixma, Marco Moia, Philip G. de Groot, Augusto B. Federici, Pier Mannuccio Mannucci, M. J. W. Ijsseldijk

Publikováno v: British Journal of Haematology. 83:88-93

Endothelial cells (EC) were isolated from the umbilical vein of a newborn girl with type I 'platelet low' von Willebrand disease (I vWD) and endothelial localization and release and the ability of subendothelial von Willebrand factor (vWF) to support

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1cabaa6adc13b6f86091c8d2fe3e4a
https://doi.org/10.1111/j.1365-2141.1993.tb04636.x

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