Zobrazeno 1 - 10
of 17
pro vyhledávání: '"M. J. Quon"'
Autor:
G, Bandyopadhyay, M P, Sajan, Y, Kanoh, M L, Standaert, M J, Quon, B C, Reed, I, Dikic, R V, Farese
Publikováno v:
The Journal of biological chemistry. 276(38)
Insulin controls glucose uptake by translocating GLUT4 and other glucose transporters to the plasma membrane in muscle and adipose tissues by a mechanism that appears to require protein kinase C (PKC)-zeta/lambda operating downstream of phosphatidyli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47e1893bd9c546c253c83b462b1a0423
https://pubmed.ncbi.nlm.nih.gov/11463795
https://pubmed.ncbi.nlm.nih.gov/11463795
Autor:
Eva Degerman, Tova Rahn Landström, Faiyaz Ahmad, Vincent C. Manganiello, Li-Tzu Wang, L N Cong, M J Quon, Jacalyn H. Pierce, Lena Stenson
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 164(9)
Wild-type (F/B), constitutively active (F/B*), and three kinase-inactive (F/Ba−, F/Bb−, F/Bc−) forms of Akt/protein kinase B (PKB) were permanently overexpressed in FDCP2 cells. In the absence of insulin-like growth factor-1 (IGF-1), activities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6227bfb2db5c63ce8e979e75a8c2e97c
https://pubmed.ncbi.nlm.nih.gov/10779773
https://pubmed.ncbi.nlm.nih.gov/10779773
Publikováno v:
The Journal of biological chemistry. 274(49)
Evidence accumulated from clinical and basic research has indirectly implicated the insulin receptor (IR) in brain cognitive functions, including learning and memory (Wickelgren, I. (1998) Science 280, 517-519). The present study investigates correla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b788f382d36d8456250271dea811d08a
https://pubmed.ncbi.nlm.nih.gov/10574963
https://pubmed.ncbi.nlm.nih.gov/10574963
Autor:
F H, Nystrom, M J, Quon
Publikováno v:
Cellular signalling. 11(8)
Biological actions of insulin are mediated by the insulin receptor, a member of a large family of receptor tyrosine kinases (RTK). Signal transduction by the insulin receptor follows a paradigm for RTK signalling. Many intracellular signalling molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::57f64e027cf77f0fad5e767657f6769e
https://pubmed.ncbi.nlm.nih.gov/10433517
https://pubmed.ncbi.nlm.nih.gov/10433517
Publikováno v:
The Journal of biological chemistry. 274(20)
Okadaic acid, an inhibitor of protein phosphatases 1 and 2A, is known to provoke insulin-like effects on GLUT4 translocation and glucose transport, but the underlying mechanism is obscure. Presently, we found in both rat adipocytes and 3T3/L1 adipocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d05403f3c97fe0cf03a4922c2cafd44
https://pubmed.ncbi.nlm.nih.gov/10318822
https://pubmed.ncbi.nlm.nih.gov/10318822
Publikováno v:
Endocrinology. 139(3)
Leptin is a hormone produced in adipose cells that regulates energy expenditure, food intake, and adiposity. To understand leptin's transcriptional regulation, we are studying its promoter. Four conserved and functional regions were identified. Mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f32cb94d824c8dd36dd736d3035c722a
https://pubmed.ncbi.nlm.nih.gov/9492033
https://pubmed.ncbi.nlm.nih.gov/9492033
Publikováno v:
The Journal of biological chemistry. 270(48)
The obese gene product, leptin, regulates adiposity. Mice homozygous for a nonfunctional obese gene become massively obese and develop diabetes mellitus due to overeating and increased metabolic efficiency. The cDNA sequence of obese was recently rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14d9d2eaa2b975f4500bf42614dbe8b7
https://pubmed.ncbi.nlm.nih.gov/7499416
https://pubmed.ncbi.nlm.nih.gov/7499416
Publikováno v:
The Journal of biological chemistry. 269(45)
Insulin signaling is initiated at least in part by activation of the insulin receptor tyrosine kinase and subsequent phosphorylation of cellular substrates such as insulin receptor substrate 1 (IRS-1). Previous studies have focused on the role of IRS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a13fb4b33b8c7744527a8deb0c98bda
https://pubmed.ncbi.nlm.nih.gov/7525563
https://pubmed.ncbi.nlm.nih.gov/7525563
Publikováno v:
Diabetes research (Edinburgh, Scotland). 25(4)
Estimates of in vivo insulin sensitivity (S1) can be derived from minimal model analysis of a frequently sampled intravenous glucose tolerance test (FSIVGTT). Modification of the FSIVGTT by administration of tolbutamide improves the correlation betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1a8742ed1b53d583040d0004bf7ca40
https://pubmed.ncbi.nlm.nih.gov/7648784
https://pubmed.ncbi.nlm.nih.gov/7648784
Publikováno v:
Biochemical and biophysical research communications. 194(1)
Isolated adipose cells are among the most insulin responsive cells with respect to glucose transport and metabolism. However, molecular biological techniques such as transfection of DNA have heretofore not been applied successfully in these cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8dabe5dd60ecba05b665322ae973a045
https://pubmed.ncbi.nlm.nih.gov/8392839
https://pubmed.ncbi.nlm.nih.gov/8392839