Zobrazeno 1 - 10 of 121 pro vyhledávání: '"M. J. O'connor"'
1
Akademický článek
Understanding tumour growth variability in breast cancer xenograft models identifies PARP inhibition resistance biomarkers
Autor: D. Voulgarelis, J. V. Forment, A. Herencia Ropero, D. Polychronopoulos, J. Cohen-Setton, A. Bender, V. Serra, M. J. O’Connor, J. W. T. Yates, K. C. Bulusu
Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract Understanding the mechanisms of resistance to PARP inhibitors (PARPi) is a clinical priority, especially in breast cancer. We developed a novel mathematical framework accounting for intrinsic resistance to olaparib, identified by fitting the
Externí odkaz: https://doaj.org/article/7c32d64fcf8148039a4f12c4b59c281c
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2
Akademický článek
Evolutionary Rescue Is Mediated by the History of Selection and Dispersal in Diversifying Metacommunities
Autor: Louise M. J. O'Connor, Vincent Fugère, Andrew Gonzalez
Publikováno v: Frontiers in Ecology and Evolution, Vol 8 (2020)
Rapid evolution can sometimes prevent population extirpation in stressful environments, but the conditions leading to “evolutionary rescue” in metacommunities are unclear. Here we studied the eco-evolutionary response of microbial metacommunities
Externí odkaz: https://doaj.org/article/321e29dde0104b93a6ed78518df5d6dd
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3
TETRA‐EU 1.0: A species‐level trophic metaweb of European tetrapods
Autor: Gentile Francesco Ficetola, Louise M. J. O’Connor, Luigi Maiorano, Wilfried Thuiller, Alessandro Montemaggiori
Publikováno v: Global Ecology and Biogeography
Global Ecology and Biogeography, Wiley, 2020, 29 (9), pp.1452-1457. ⟨10.1111/geb.13138⟩
International audience; Documenting potential interactions between species represents a major step towards understanding and predicting the spatial and temporal structure of multi‐trophic communities and their functioning. The metaweb concept summa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4a1baae63569eeb6f19a25a4c67a5c
https://doi.org/10.1111/geb.13138
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4
Balancing conservation priorities for nature and for people in Europe
Autor: Julien Renaud, Laura J. Pollock, Willem Verhagen, Louise M. J. O’Connor, Wilfried Thuiller, Luigi Maiorano, Peter H. Verburg, Sandra Lavorel
Publikováno v: Science
Science, American Association for the Advancement of Science, 2021, 372 (6544), pp.856-860. ⟨10.1126/science.abc4896⟩
Science, 372(6544), 856-860. American Association for the Advancement of Science
O'Connor, L M J, Pollock, L J, Renaud, J, Verhagen, W, Verburg, P H, Lavorel, S, Maiorano, L & Thuiller, W 2021, ' Balancing conservation priorities for nature and for people in Europe ', Science, vol. 372, no. 6544, pp. 856-860 . https://doi.org/10.1126/science.abc4896
Priorities to protect nature in Europe There is consensus among conservation scientists that protected areas should be expanded to safeguard biodiversity and ecosystem services, but it is often difficult to prioritize areas for protection. Considerin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930fbf9ec447f4e8319d5a8396625f11
https://hal-cnrs.archives-ouvertes.fr/hal-03346487
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5
Diversity indices for ecological networks: a unifying framework using Hill numbers
Autor: Loïc Chalmandrier, Marc Ohlmann, Wilfried Thuiller, Vincent Miele, Stéphane Dray, Louise M. J. O’Connor
Publikováno v: Ecology Letters
Ecology Letters, Wiley, 2019, 22 (4), pp.737-747. ⟨10.1111/ele.13221⟩
Describing how ecological interactions change over space and time and how they are shaped by environmental conditions is crucial to understand and predict ecosystem trajectories. However, it requires having an appropriate framework to measure network
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df7205a911f8a8222c18e2633bb53c2
https://doi.org/10.1111/ele.13221
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6
Unveiling the food webs of tetrapods across Europe through the prism of the Eltonian niche
Autor: Alessandro Montemaggiori, Luigi Maiorano, Gentile Francesco Ficetola, Wilfried Thuiller, Louise M. J. O’Connor, Marc Ohlmann, João Braga, Camille Martinez‐Almoyna, Laura J. Pollock
Publikováno v: Journal of Biogeography
Journal of Biogeography, Wiley, 2020, 47 (1), pp.181-192. ⟨10.1111/jbi.13773⟩
AIM: Despite recent calls for integrating interaction networks into the study of large‐scale biodiversity patterns, we still lack a basic understanding of the functional characteristics of large interaction networks and how they are structured acro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b084106ef81ad1015fcc53154d42c91
https://hal.archives-ouvertes.fr/hal-02462181/file/OConnor2020JBI.pdf
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7
Differential regulation of protein synthesis by amino acids and insulin in peripheral and visceral tissues of neonatal pigs
Autor: Jill A. Bush, Hanh V. Nguyen, Teresa A. Davis, Pamela M. J. O'Connor, Agus Suryawan
Publikováno v: Amino Acids. 37:97-104
The high efficiency of protein deposition during the neonatal period is driven by high rates of protein synthesis, which are maximally stimulated after feeding. In the current study, we examined the individual roles of amino acids and insulin in the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0b90e283346f778a7f974d8c98385c
https://doi.org/10.1007/s00726-008-0149-z
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9
Modulation of muscle protein synthesis by insulin is maintained during neonatal endotoxemia
Autor: Renán A. Orellana, M. Carole Thivierge, Teresa A. Davis, Jill A. Bush, Marta L. Fiorotto, Hanh V. Nguyen, Pamela M. J. O'Connor, Agus Suryawan
Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 291:E159-E166
Sepsis promotes insulin resistance and reduces protein synthesis in skeletal muscle of adults. The effect of sepsis on insulin-stimulated muscle protein synthesis has not been determined in neonates, a highly anabolic population that is uniquely sens
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097be365652b2e4d692a21363b08d0e7
https://doi.org/10.1152/ajpendo.00595.2005
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10
The Role of the HPA Axis in Psychiatric Disorders and CRF Antagonists as Potential Treatments
Autor: Paul A. Keller, Sean M. J. O'Connor, Jody Morgan, Adam McCluskey
Publikováno v: Archiv der Pharmazie. 339:346-355
An overview of the links between the Hypothalamic-Pituitary-Adrenal (HPA) axis and psychiatric disorders is presented. The current treatments are outlined, indicating that they are insufficient to meet the needs of those that suffer from these affect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25fc80705b2a2c4cb3acc213eb6194a
https://doi.org/10.1002/ardp.200600021
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