Zobrazeno 1 - 3
of 3
pro vyhledávání: '"M. J. M. Dirks"'
Publikováno v:
Pharmaceutisch weekblad. Scientific edition. 12(2)
The pharmacokinetics of racemic baclofen as determined from plasma and urine data in six spastic patients treated with individualized oral doses, 30-80 mg daily, are presented. Peak plasma concentrations were achieved 1.9 h (+/- 0.7) after a dose. Th
Publikováno v:
European journal of clinical pharmacology. 37(2)
Baclofen, a centrally acting muscle relaxant, is used in the treatment of spasticity. Its pharmacokinetics has been derived from plasma and urine data in four healthy subjects, whose renal function was simultaneously measured. After oral administrati
Autor:
B. Winograd, Tom B. Vree, M. J. M. Dirks, M. J. M. Oosterbaan, Robert J. J. Lippens, E. van der Kleijn
Publikováno v:
European journal of clinical pharmacology. 30(2)
In children with lymphoid malignancies 18 courses of methotrexate (18–200 mg/kg) administered as a 24-h infusion were monitored. Plasma concentrations and renal excretion rates of methotrexate (MTX) and 7-hydroxymethotrexate (7-OHMTX) were determin