Zobrazeno 1 - 10 of 30 pro vyhledávání: '"M. J. Lenardo"'
1
Characteristic T helper 2 T cell cytokine abnormalities in autoimmune lymphoproliferative syndrome, a syndrome marked by defective apoptosis and humoral autoimmunity
Autor: I J Fuss, W Strober, J K Dale, S Fritz, G R Pearlstein, J M Puck, M J Lenardo, S E Straus
Publikováno v: The Journal of Immunology. 158:1912-1918
Autoimmune lymphoproliferative syndrome (ALPS) is marked by massive lymphadenopathy, hepatosplenomegaly, autoimmunity and the presence of increased numbers of circulating and tissue TCR-alpha beta, CD4- CD8- T cells. The underlying defect is that of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b7b8c240f22dd1f7e733e9c7e8190dd
https://doi.org/10.4049/jimmunol.158.4.1912
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2
TCR-mediated death of mature T lymphocytes occurs in the absence of p53
Autor: S A Boehme, M J Lenardo
Publikováno v: The Journal of Immunology. 156:4075-4078
The p53 protein plays an important role in various forms of thymocyte apoptosis, however its role in mature T lymphocyte death caused by TCR stimulation has not been examined. We demonstrate here that T cell blasts derived from mice containing a germ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec5188aa06857976a72baa1c0288f6c8
https://doi.org/10.4049/jimmunol.156.11.4075
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3
Analysis of the CD4 coreceptor and activation-induced costimulatory molecules in antigen-mediated mature T lymphocyte death
Autor: S A Boehme, L Zheng, M J Lenardo
Publikováno v: The Journal of Immunology. 155:1703-1712
We have compared the signaling requirements for activation and lymphokine production in mature T lymphocytes to those required for TCR-driven programmed cell death (PCD). Both processes require TCR engagement and ligation of the CD4 coreceptor in the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f73b61075087fe1bfed564cf6c23537
https://doi.org/10.4049/jimmunol.155.4.1703
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4
Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from multiple sclerosis patients and normal individuals
Autor: C M Pelfrey, L R Tranquill, S A Boehme, H F McFarland, M J Lenardo
Publikováno v: The Journal of Immunology. 154:6191-6202
Several stimuli induce mature T cells to undergo apoptosis or programmed cell death (PCD) including specific Ag. We have demonstrated previously that Ag induces the death of encephalitogenic T cells in vitro and deletion in vivo, leading to ameliorat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05c4e60026b5db6367842ee9d60191e1
https://doi.org/10.4049/jimmunol.154.11.6191
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5
A novel tumor necrosis factor-responsive transcription factor which recognizes a regulatory element in hemopoietic growth factor genes
Autor: Elizabeth Kuczek, S M Dunn, M F Shannon, M J Lenardo, F S Occhiodoro, L M Pell, Mathew A. Vadas
Publikováno v: Molecular and Cellular Biology. 10:2950-2959
A conserved DNA sequence element, termed cytokine 1 (CK-1), is found in the promoter regions of many hemopoietic growth factor (HGF) genes. Mutational analyses and modification interference experiments show that this sequence specifically binds a nuc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51e8d5be4b8f0aca71c576d6da11bc32
https://doi.org/10.1128/mcb.10.6.2950
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7
Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein
Autor: F K, Chan, R M, Siegel, D, Zacharias, R, Swofford, K L, Holmes, R Y, Tsien, M J, Lenardo
Publikováno v: Cytometry. 44(4)
Fluorescence resonance energy transfer (FRET) is a powerful technique for measuring molecular interactions at Angstrom distances. We present a new method for FRET that utilizes the unique spectral properties of variants of the green fluorescent prote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a3d4f18bb316bf6fc72521ebb259ab3
https://pubmed.ncbi.nlm.nih.gov/11500853
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8
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk
Autor: M, Chamorro, M J, Czar, J, Debnath, G, Cheng, M J, Lenardo, H E, Varmus, P L, Schwartzberg
Publikováno v: BMC Immunology
Background The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases. For most Tec kinases, this activation requires an interaction between their pleckstrin homolog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d010969051c38f4707f9e49ed9555e9f
https://pubmed.ncbi.nlm.nih.gov/11353545
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