Zobrazeno 1 - 10
of 100
pro vyhledávání: '"M. J. Kreek"'
Publikováno v:
Journal of Pharmaceutics & Pharmacology. 9
Alcohol relapse is the treatment target for medications development for alcohol dependence. Aticaprant, a selective and short-acting kappa-opioid receptor (KOR) antagonist, has recently been under development for new clinical implications (depression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e163a43b66a50fc9821ec7fa8320b63
https://doi.org/10.13188/2327-204x.1000032
https://doi.org/10.13188/2327-204x.1000032
Publikováno v:
BioTechniques. 25:198-206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ef58856c4a7a68b698b938f1e31855
https://doi.org/10.2144/98252bm04
https://doi.org/10.2144/98252bm04
Publikováno v:
Neuroscience. 169(2)
There is evidence that the kappa opioid system plays an important role in cocaine addiction and that chronic cocaine administration and withdrawal from chronic cocaine alter kappa opioid receptor (KOPr) density. The present study employed in situ [(3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d245d60adb9ccd6a631683132443f677
https://pubmed.ncbi.nlm.nih.gov/20452406
https://pubmed.ncbi.nlm.nih.gov/20452406
Publikováno v:
Acta psychiatrica Scandinavica. Supplementum. (412)
Drugs of abuse have a significant impact on the stress responsive hypothalamic-pituitary-adrenal (HPA) axis and an abnormal response to stress may mediate the development or maintenance of addictive diseases. In animals, drugs of abuse, such as cocai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7bd7b434f8ac9d0599c6cbdec10f30a9
https://pubmed.ncbi.nlm.nih.gov/12072142
https://pubmed.ncbi.nlm.nih.gov/12072142
Autor:
Y, Zhou, E M, Unterwald, A, Ho, K S, LaForge, V P, Yuferov, J, Kreuter, M J, Sirianni, R G, Allen, M J, Kreek
Publikováno v:
Journal of neuroendocrinology. 13(9)
The hypothalamic-pituitary-adrenal (HPA) axis is regulated by stress-related excitatory inputs, and various inhibitory and negative-feedback controls by glucocorticoids and opioids, including pro-opiomelanocortin (POMC)-derived peptides. The role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::942bc069f9f343d7d4a9d935eae1d066
https://pubmed.ncbi.nlm.nih.gov/11578531
https://pubmed.ncbi.nlm.nih.gov/11578531
Autor:
M J, Kreek
Publikováno v:
Annals of the New York Academy of Sciences. 937
Addiction to alcohol, tobacco, and illicit drugs of abuse continues to be one of the most significant medical, social, and economic problems facing our society. Since the mid-1960s, addictions have been recognized as diseases. We have hypothesized th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd16f8b5d548a4d3f3aaf5a50869b86e
https://pubmed.ncbi.nlm.nih.gov/11458539
https://pubmed.ncbi.nlm.nih.gov/11458539
Autor:
M A, Kling, R E, Carson, L, Borg, A, Zametkin, J A, Matochik, J, Schluger, P, Herscovitch, K C, Rice, A, Ho, W C, Eckelman, M J, Kreek
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(3)
Stabilized methadone-maintained former heroin addicts (MTPs) treated with effective doses of methadone have markedly reduced drug craving; reduction or elimination of heroin use; normalized stress-responsive hypothalamic-pituitary-adrenal, reproducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aaa4cfa2eef13cd44b47dda960aca61a
https://pubmed.ncbi.nlm.nih.gov/11082442
https://pubmed.ncbi.nlm.nih.gov/11082442
Autor:
B, Stimmel, M J, Kreek
Publikováno v:
The Mount Sinai journal of medicine, New York. 67(5-6)
Scientific information about the neurobiology of addictive behaviors provides an increasingly important rationale to support opioid agonist pharmacotherapy, primarily methadone maintenance treatment, for long-term heroin addiction. In late 1963 and 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da748fcff216771ef01d35f18313a470
https://pubmed.ncbi.nlm.nih.gov/11064487
https://pubmed.ncbi.nlm.nih.gov/11064487
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(2)
The effects of i.v. dynorphin A(1-17) and its main nonopioid biotransformation fragment, dynorphin A(2-17), were compared in rhesus monkeys with those of the selective kappa-opioid agonist, U69, 593, in assays of operant behavior, thermal antinocicep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::475cab0e6d8e69db6fb95deb5d062b4b
https://pubmed.ncbi.nlm.nih.gov/10411578
https://pubmed.ncbi.nlm.nih.gov/10411578
Publikováno v:
Alcoholism, clinical and experimental research. 23(3)
Opiate antagonists have been found to stimulate the hypothalamic-pituitary-adrenal axis. However, despite established usefulness in the management of alcoholism, systematic, oral dose-titrated natrexone-induced hypothalamic-pituitary-adrenal stimulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b03801fc3564c9cdf7b3c1d68876b2bc
https://pubmed.ncbi.nlm.nih.gov/10195825
https://pubmed.ncbi.nlm.nih.gov/10195825