Zobrazeno 1 - 10
of 70
pro vyhledávání: '"M. J. Kohan"'
Publikováno v:
Microbial Ecology in Health and Disease. 9:143-156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::940eb830491fde1dd925b466053aba3f
https://doi.org/10.3109/08910609609166455
https://doi.org/10.3109/08910609609166455
Publikováno v:
Mutagenesis. 10:497-504
The mutagenic environmental pollutants 2-nitrofluoranthene (2-NFA) and 3-nitrofluoranthene (3-NFA), labelled with 3H and 14C respectively, were incubated with Salmonella typhimurium strain TA98, its nitroreductase-deficient variant TA98NR and its O-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb12ce676186e494edca1438239bfc8d
https://doi.org/10.1093/mutage/10.6.497
https://doi.org/10.1093/mutage/10.6.497
Publikováno v:
Cancer Letters. 79:181-187
After male germ-free and conventionalized Fischer 344 rats were administered per os (p.o.) 75 mg/kg 2,6-DNT, intestinal nitroreductase, beta-glucuronidase, and azo reductase activities were lower in the cecum and large intestine of germ-free animals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc87bc2e58f691508403da5c8b69b30
https://doi.org/10.1016/0304-3835(94)90258-5
https://doi.org/10.1016/0304-3835(94)90258-5
Autor:
S. E. GEORGE, R. W. CHADWICK, J. J. CHANG, M. J. KOHAN, J. C. ALLLSON, J. P. DEKKER, Y. HAYES
Publikováno v:
Toxicological Sciences. 18:240-246
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1554602ee2be7767b474002a8dd8767e
https://doi.org/10.1093/toxsci/18.2.240
https://doi.org/10.1093/toxsci/18.2.240
Autor:
M. J. Kohan, Jan-Ake Gustafsson, Bertil Gustafsson, Louise M. Ball, J. Rafter, Joellen Lewtas
Publikováno v:
Carcinogenesis. 12:1-5
1-Nitropyrene (NP), an environmental pollutant, a potent mutagen and an animal carcinogen, undergoes reduction, acetylation, ring-hydroxylation and conjugation in the rat in vivo to form mutagenic metabolites which are excreted in the urine. In order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c31ac9b8075f2bec05898e25458ff8
https://doi.org/10.1093/carcin/12.1.1
https://doi.org/10.1093/carcin/12.1.1
Publikováno v:
Journal of toxicology and environmental health. Part A. 63(4)
When oil is spilled into aquatic systems, chemical dispersants frequently are applied to enhance emulsification and biological availability. In this study, a mammalian model system was used to determine the effect of Bonnie Light Nigerian crude oil,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7c1200fadd28a05486ee2fe407c90e
https://pubmed.ncbi.nlm.nih.gov/11437062
https://pubmed.ncbi.nlm.nih.gov/11437062
Publikováno v:
Molecular carcinogenesis. 26(2)
Dibenzo[a,l]pyrene (DB[a,l]P), an extremely potent environmental carcinogen, is metabolically activated in mammalian cells and microsomes through the fjord-region dihydrodiol, trans-DB[a,l]P-11, 12-diol, to syn- and anti-DB[a,l]P-11,12-diol-13,14-epo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03b12686266406bb9ae72c96c1cc9245
https://pubmed.ncbi.nlm.nih.gov/10506751
https://pubmed.ncbi.nlm.nih.gov/10506751
Publikováno v:
Environmental and molecular mutagenesis. 31(3)
Due to its widespread use as a preemergent herbicide, alachlor has been detected as a groundwater contaminant. The procarcinogen, 2,6-dinitrotoluene (DNT), a by-product of the munitions industry and a precursor to polyurethane production, is found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::106f6933b4b41600b9f0ce1897942000
https://pubmed.ncbi.nlm.nih.gov/9585266
https://pubmed.ncbi.nlm.nih.gov/9585266
Publikováno v:
Environmental and molecular mutagenesis. 30(3)
The production and storage of explosives has resulted in the environmental accumulation of the mutagen 2,4,6-trinitrotoluene (TNT). In order to characterize the production of mutagenic urinary metabolites, 6-week old male Fischer 344 rats were admini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3962f3cd8ff96b1ea88987f135d86056
https://pubmed.ncbi.nlm.nih.gov/9366908
https://pubmed.ncbi.nlm.nih.gov/9366908
Hepatic DNA adducts and production of mutagenic urine in 2,6-dinitrotoluene-treated B6C3F1 male mice
Publikováno v:
Cancer letters. 102(1-2)
The hepatocarcinogen 2,6-dinitrotoluene (2,6-DNT) is an intermediate in the chemical synthesis of 2,4,6-trinitrotoluene and polyurethane products and can contaminate the waste stream emitted by these industries. In this study, the production of mutag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3070bb15ba0cd4277279839498839d5b
https://pubmed.ncbi.nlm.nih.gov/8603358
https://pubmed.ncbi.nlm.nih.gov/8603358