Zobrazeno 1 - 10
of 14
pro vyhledávání: '"M. J. KUKLA"'
Autor:
H J, Breslin, M J, Kukla, D W, Ludovici, R, Mohrbacher, W, Ho, M, Miranda, J D, Rodgers, T K, Hitchens, G, Leo, D A, Gauthier
Publikováno v:
Journal of Medicinal Chemistry. 38:771-793
4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2 (1H)-ones (TIBO), 1, have been shown to significantly inhibit HIV-1 replication in vitro by interfering with the virus's reverse transcriptase enzyme. They have also demonstrated potent
Autor:
M. J. KUKLA, H. J. BRESLIN, R. PAUWELS, C. L. FEDDE, M. MIRANDA, M. K. SCOTT, R. G. SHERRILL, A. RAEYMAEKERS, J. VAN GELDER, K. ANDRIES, M. A. C. JANSSEN, E. DE CLERQ, P. A. J. JANSSEN
Publikováno v:
ChemInform. 22
Autor:
Joanne R. Mathiasen, M. J. Kukla, D. L. Barrett, Gregory E. Martin, James M. Kesslick, M. K. Scott, D. L. Distefano, C. L. Fedde, Richard P. Shank, J. L. Vaught, William J. Baldy, R. J. Jun. Elgin
Publikováno v:
ChemInform. 23
Autor:
C. R. Rasmussen, M. J. Renzi, Allen B. Reitz, J. L. Vaught, Richard P. Shank, C. F. Schwender, E. W. Baxter, E. E. Codd, E. A. Malloy, C. A. Maryanoff, Malcolm K. Scott, M. E. Ortegon, F. J. Villani, R. G. Sherrill, P. S. Blum, N. Yim, D. J. Bennett, Robert E. Boyd, Bruce E. Maryanoff, M. J. Kukla
Publikováno v:
ChemInform. 27
Publikováno v:
Proceedings of LEOS'94.
Summary form only given. This paper will address the design and performance of Nd:YAG lasers with average powers in the kilowatt range, and beam quality approaching the diffraction limit. Both slab and rod geometries will be discussed.
Autor:
W, Ho, M J, Kukla, H J, Breslin, D W, Ludovici, P P, Grous, C J, Diamond, M, Miranda, J D, Rodgers, C Y, Ho, E, De Clercq
Publikováno v:
Journal of medicinal chemistry. 38(5)
In previous papers, we have described the discovery of a new series of compounds, 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1 H)- ones, TlBO (1 and 1a), with potent anti-HIV-1 activity and the synthesis of analogues to better d
Autor:
M. J. Kukla, Mathiasen, Gregory E. Martin, Robert J. Elgin, C. L. Fedde, D. L. Distefano, D. L. Barrett, James M. Kesslick, William J. Baldy, M. K. Scott
Publikováno v:
Journal of medicinal chemistry. 35(3)
Recently, we reported on a series of arylpiperazines 4 which exhibit high affinity for the serotonin 5-HT-1A and 5-HT-1B binding sites. Although these compounds interact weakly with dopamine D-1 and D-2 receptors, they are reasonably potent in inhibi
Autor:
M J, Kukla, H J, Breslin, R, Pauwels, C L, Fedde, M, Miranda, M K, Scott, R G, Sherrill, A, Raeymaekers, J, Van Gelder, K, Andries
Publikováno v:
Journal of medicinal chemistry. 34(2)
A series of 6-substituted 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-ones (9) have been synthesized and tested for their ability to inhibit the replication of the HIV-1 virus in MT-4 cells. Two synthetic methods are describ
Autor:
M. J. KUKLA
Publikováno v:
Chemischer Informationsdienst. 14
Autor:
M. J. KUKLA
Publikováno v:
Chemischer Informationsdienst. 10