Zobrazeno 1 - 10
of 60
pro vyhledávání: '"M. J. Hobart"'
Autor:
David Clayton, M. J. Hobart, Hywel B. Jones, Peter N. Goodfellow, Francesca Coraddu, Stephen Sawcer, Jeremy Chataway, Alastair Compston, Julia Gray, David Sherman, Simon Broadley, B A Fernie, Robert Feakes
Publikováno v:
Journal of Neuroimmunology. 99:150-156
Four genome screens in multiple sclerosis have been completed and each has identified evidence for linkage in the pericentromeric region of chromosome 5. This region encodes a number of candidate genes including those for the complement components C6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74878e8e83330a5d6234eaccafd70e96
https://doi.org/10.1016/s0165-5728(99)00054-5
https://doi.org/10.1016/s0165-5728(99)00054-5
Autor:
B A Fernie, M. J. Hobart
Publikováno v:
Experimental and Clinical Immunogenetics. 16:150-161
Five new polymorphisms in the C7 gene are described: 2 in intron 1, and 1 each in introns 7, 8 and 15. Four of these are single nucleotide exchanges, while the fifth is a T insertion at 10 sequential Ts. Allele frequency data are presented for interv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4ec4c984afa5c48ebfddf390f017ed
https://doi.org/10.1159/000019107
https://doi.org/10.1159/000019107
Autor:
Thomas Kaufmann, Christian Rittner, Reinhard Würzner, A. Orren, K. Witzel-Schlömp, M. J. Hobart, B A Fernie, Peter M. Schneider
Publikováno v:
Immunogenetics. 48:144-147
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bff5ecb6a063643f718ad3ce2344b10
https://doi.org/10.1007/s002510050415
https://doi.org/10.1007/s002510050415
Publikováno v:
The Journal of Immunology. 159:1019-1026
The molecular basis of C7 deficiency has been investigated in two Irish families and a number of Israeli families of Moroccan Sephardic Jewish origin. Exon PCR and sequencing revealed a heterozygous point mutation at the 3' splice acceptor site of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc27c6eb1a3c1a3c9fa3f828571ede29
https://doi.org/10.4049/jimmunol.159.2.1019
https://doi.org/10.4049/jimmunol.159.2.1019
Autor:
Reinhard Würzner, B A Fernie, R. C. Cooper, Y. E. Williams, Alexander E. Platonov, A. Orren, M. J. Hobart, M Schlesinger
Publikováno v:
Annals of Human Genetics. 61:287-298
Eight common DNA polymorphisms have been described for the linked C6 and C7 genes. We now describe a ninth polymorphism in C7 exon 13 which is located in a tight cluster with two previously reported markers. We have used all these markers to investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799bd14fb391ffb8051d2521fcfdf438
https://doi.org/10.1046/j.1469-1809.1997.6140287.x
https://doi.org/10.1046/j.1469-1809.1997.6140287.x
Publikováno v:
The Journal of Immunology. 158:5043-5049
The ninth component of human complement (C9) is the last of the terminal complement components creating the membrane attack complex. C9 is a single-chain serum protein that is encoded by a gene located on chromosome 5p. Deficiency of terminal complem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb03bad9e856069565883bbdbbbd4d06
https://doi.org/10.4049/jimmunol.158.10.5043
https://doi.org/10.4049/jimmunol.158.10.5043
Publikováno v:
Annals of Human Genetics. 60:179-182
We report a new polymorphism in the complement C7 gene that results from an A-C transversion in intron 12, 27 bp upstream of exon 13 (C712.-27) and 36 bp upstream of the point mutation that underlies the C7 M/N antigenic polymorphism. The C7 12.-27 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e523cf1775dd15cbbbea178d31980e5
https://doi.org/10.1111/j.1469-1809.1996.tb01187.x
https://doi.org/10.1111/j.1469-1809.1996.tb01187.x
Publikováno v:
The Journal of Immunology. 154:5188-5194
The seventh component of complement is a single chain plasma glycoprotein that is involved in the cytolytic phase of complement activation. We have determined the structure of the C7 gene, which is encoded by 18 exons whose sizes vary from 56 to 244
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac80529bc4f9efe41f2db78bfbd55d19
https://doi.org/10.4049/jimmunol.154.10.5188
https://doi.org/10.4049/jimmunol.154.10.5188
Publikováno v:
Parasite Immunology. 17:245-251
In the present study we have investigated the fluid phase activation of the complement (C) alternative pathway by Echinococcus granulosus sheep hydatid cyst fluid (SHCF) and its higher molecular weight fraction (SHCF-I) by quantitating the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3940e3f7a64ee24c76e3c147bfe20173
https://doi.org/10.1111/j.1365-3024.1995.tb01022.x
https://doi.org/10.1111/j.1365-3024.1995.tb01022.x
Publikováno v:
The Journal of Immunology. 154:4813-4819
The allotypes of the C7 M/N polymorphism are determined by comparing the ELISA reaction pattern of the allospecific mAb WU 4-15 with polyclonal anti-C7 IgG. To characterize the molecular basis of this polymorphism, the WU 4-15 epitope was mapped by e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b927acda94791eb244b0e8b2227925c8
https://doi.org/10.4049/jimmunol.154.9.4813
https://doi.org/10.4049/jimmunol.154.9.4813