Zobrazeno 1 - 10
of 48
pro vyhledávání: '"M. J. Dunne"'
Autor:
David Dorr, Chris D'Autremont, Joshua E Richardson, Michelle Bobo, Christopher Terndrup, M J Dunne, Anthony Cheng, Robert Rope
Publikováno v:
JMIR Cardio, Vol 7, p e39490 (2023)
BackgroundHigh blood pressure (HBP) affects nearly half of adults in the United States and is a major factor in heart attacks, strokes, kidney disease, and other morbidities. To reduce risk, guidelines for HBP contain more than 70 recommendations, in
Externí odkaz:
https://doaj.org/article/f171fe34074144ae9404438a5040f738
Autor:
Bowen Chung, William J.A. Pinnock, Jon Puro, Ana Quiñones, Mitchell R. Lunn, Georgia M Reid, John Heintzman, Erika Cottrell, Rebecca G Block, M. J. Dunne
Publikováno v:
J Am Med Inform Assoc
Health and healthcare disparities continue despite clinical, research, and policy efforts. Large clinical datasets may not contain data relevant to healthcare disparities and leveraging these for research may be crucial to improve health equity. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054c3af5a0d685f97924d106bac3cf38
https://europepmc.org/articles/PMC7671626/
https://europepmc.org/articles/PMC7671626/
Autor:
William F. Pralong, Ole H. Petersen, M J Dunne, Jean-Marc Theler, D Milani, Guodong Li, Claes B. Wollheim
Publikováno v:
Journal of Biological Chemistry. 266:3449-3457
The mechanism by which extracellular ATP stimulates insulin secretion was investigated in RINm5F cells. ATP depolarized the cells as demonstrated both by using the patch-clamp technique and a fluorescent probe. The depolarization is due to closure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e82566398cd2e3361b5dad299665fdc
https://doi.org/10.1016/s0021-9258(19)67816-6
https://doi.org/10.1016/s0021-9258(19)67816-6
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1055:157-164
The effects of alanine, glucose and tolbutamide on insulin-secreting cells (RINm5F) have been investigated using patch-clamp and single cell intracellular Ca2+ measurements. When directly challenged with the amino acid l -alanine (2–10 mM) the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0717680f2875c790ab93179af8ef1cd4
https://doi.org/10.1016/0167-4889(90)90116-u
https://doi.org/10.1016/0167-4889(90)90116-u
Publikováno v:
The Journal of Membrane Biology. 114:53-60
Patch-clamp and single cell [Ca2+]i measurements have been used to investigate the effects of the potassium channel modulators cromakalim, diazoxide and tolbutamide on the insulin-secreting cell line RINm5F. In intact cells, with an average cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1c3ddcc8d9c1254fc274b693645e77
https://doi.org/10.1007/bf01869384
https://doi.org/10.1007/bf01869384
Autor:
M. J. Dunne
Publikováno v:
British Journal of Pharmacology. 99:487-492
1. The whole-cell patch-clamp technique has been used to investigate the effects of pinacidil, RP 49356 and nicorandil on membrane potential and adenosine 5'-triphosphate (ATP)-sensitive K+ channel currents in the insulin-secreting cell line RINm5F.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838d46c36f6caba45d3af0ae1713e48a
https://doi.org/10.1111/j.1476-5381.1990.tb12955.x
https://doi.org/10.1111/j.1476-5381.1990.tb12955.x
Publikováno v:
British Journal of Pharmacology. 99:169-175
1. The single-channel current recording technique has been used to investigate the effects of cromakalim, diazoxide and ATP, separately and combined, on the opening of ATP-sensitive potassium channels in the insulin-secreting cell-line RINm5F. The ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5920baa69131394c9ea9aba3f258948
https://doi.org/10.1111/j.1476-5381.1990.tb14672.x
https://doi.org/10.1111/j.1476-5381.1990.tb14672.x
Autor:
B, Becker, M H, Antoine, Q A, Nguyen, B, Rigo, K E, Cosgrove, P D, Barnes, M J, Dunne, B, Pirotte, P, Lebrun
Publikováno v:
British journal of pharmacology. 134(2)
Original quinolinone derivatives structurally related to diazoxide were synthesized and their effects on insulin secretion from rat pancreatic islets and the contractile activity of rat aortic rings determined. A concentration-dependent decrease of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::852e0b36c6fab93ed2e59449b0b9c9f2
https://pubmed.ncbi.nlm.nih.gov/11564656
https://pubmed.ncbi.nlm.nih.gov/11564656
Publikováno v:
Archives of disease in childhood. Fetal and neonatal edition. 82(2)
Insulin is synthesised, stored, and secreted from pancreatic beta cells. These are located within the islets of Langerhans, which are distributed throughout the pancreas. Less than 2% of the total pancreas is devoted to an endocrine function. When th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5943c5ad97afe405e2270e702a67888
https://pubmed.ncbi.nlm.nih.gov/10685980
https://pubmed.ncbi.nlm.nih.gov/10685980
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
The aim of the present study was to characterize the effects of BM 208 (N-[4-(5-chloro-2-methoxybenzamidoethyl)benzenesulfonyl]-N'-cyano- N"- cyclohexylguanidine) and BM 225 (1-[4-(5-chloro-2-methoxybenzamidoethyl)benzene sulfonamido]-1-cyclohexylami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cb3e986af38424ae486bb9d4aaeb7b9
https://pubmed.ncbi.nlm.nih.gov/10215632
https://pubmed.ncbi.nlm.nih.gov/10215632