Zobrazeno 1 - 10
of 10
pro vyhledávání: '"M. J. Conklyn"'
Autor:
J. Angilly, H. J. Showell, M. Mansour, S. J. Hawrylik, V. L. Cohan, Craig M. Lilly, M. J. Conklyn, B. Nalcerio, S. E. Lee, M. Karmilowicz, Dennis E. Danley, Jeffrey M. Drazen, J. R. De Wet, D. D. Auperin
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 270:L1002-L1007
To study the role interleukin (IL)-5 may play in altering airway function in asthma, we have produced recombinant protein for exogenous administration to guinea pigs. The guinea pig IL-5 (gpIL-5) cDNA was cloned by polymerase chain reaction (PCR) amp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3fe82186f65574491fb1a082b2edf2
https://doi.org/10.1152/ajplung.1996.270.6.l1002
https://doi.org/10.1152/ajplung.1996.270.6.l1002
Autor:
K. Neote, Terence J. Hadley, J. Hesselgesser, Richard Horuk, Stephen C. Peiper, M. J. Conklyn, Zhao-Hai Lu, K. Ogborne, Zi-Xuan Wang, H. J. Showell, A. W. Martin
Publikováno v:
The Journal of Experimental Medicine
The Duffy antigen/receptor for chemokines (DARC), first identified on erythrocytes, functions not only as a promiscuous chemokine receptor but also as a receptor for the malarial parasite, Plasmodium vivax. The recent finding that DARC is ubiquitousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb27e826f7e70af18ac81c33214b33f
https://doi.org/10.1084/jem.181.4.1311
https://doi.org/10.1084/jem.181.4.1311
Autor:
Norma P. Gerard, H J Showell, Lee F. Kolakowski, M J Conklyn, Carmen R. Bozic, C von Uexkull-Guldenband, Craig Gerard, R Breslow
Publikováno v:
Journal of Biological Chemistry. 269:29355-29358
KC, the product of an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor, was synthesized as a recombinant protein in Escherichia coli and binds with 0.8 nM affinity to mouse neutrophils. Human neutrophils also bind r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b827a47ab329e1c0b51019934fa3332
https://doi.org/10.1016/s0021-9258(18)43882-3
https://doi.org/10.1016/s0021-9258(18)43882-3
Autor:
H J, Showell, M J, Conklyn, R, Alpert, G P, Hingorani, K F, Wright, M A, Smith, E, Stam, E D, Salter, D N, Scampoli, S, Meltzer, L A, Reiter, K, Koch, A D, Piscopio, S R, Cortina, A, Lopez-Anaya, E R, Pettipher, A J, Milici, R J, Griffiths
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(3)
CP-195543 [(+)-2-(3-benzyl-4-hydroxy-chroman-7-yl)-4-trifluoromethyl-benzoic acid] is a structurally novel, selective and potent leukotriene B4 (LTB4) receptor antagonist. In vitro CP-195543 inhibited [3H]LTB4 binding to high-affinity LTB4 receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8820a50f6b81802f34218a6f301f753
https://pubmed.ncbi.nlm.nih.gov/9618393
https://pubmed.ncbi.nlm.nih.gov/9618393
Autor:
M J, Conklyn, H J, Showell
Publikováno v:
Methods in enzymology. 287
We have described an assay that monitors the activating effects of a variety of chemokines on leukocyte subsets in human whole blood. This procedure has the following advantages: (1) minimal manipulation of the cells, (2) maintenance of more physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::523cdc23d8abaf162853f9c3cdc33bb2
https://pubmed.ncbi.nlm.nih.gov/9330334
https://pubmed.ncbi.nlm.nih.gov/9330334
Autor:
B Owens, C R Turner, P Lee, J W Watson, R Breslow, Catharine J. Andresen, H J Showell, M J Conklyn, A. Lopez-Anaya, D K Patterson
Publikováno v:
The Journal of clinical investigation. 97(2)
To test the hypothesis that leukotriene (LT) B4 antagonists may be clinically useful in the treatment of asthma, CP-105,696 was evaluated in vitro, using chemotaxis and flow cytometry assays, and in vivo, using a primate asthma model. CP-105,696 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c9e8c91d6a9b60c85758bb8b192749
https://pubmed.ncbi.nlm.nih.gov/8567958
https://pubmed.ncbi.nlm.nih.gov/8567958
Autor:
C R, Bozic, L F, Kolakowski, N P, Gerard, C, Garcia-Rodriguez, C, von Uexkull-Guldenband, M J, Conklyn, R, Breslow, H J, Showell, C, Gerard
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 154(11)
KC, the product of an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor, was expressed in Escherichia coli by using a maltose binding protein vector and biochemically characterized as a ligand for both murine and hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b0d1ff7b63f578c31e1b405e33c6d14
https://pubmed.ncbi.nlm.nih.gov/7751647
https://pubmed.ncbi.nlm.nih.gov/7751647
Autor:
H J, Showell, E R, Pettipher, J B, Cheng, R, Breslow, M J, Conklyn, C A, Farrell, G P, Hingorani, E D, Salter, B C, Hackman, D J, Wimberly
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 273(1)
CP-105696, (+)-1-(3S,4R)-[3-(4-phenyl-benzyl)-4-hydroxy-chroman-7-yl] cyclopentane carboxylic acid, is a structurally novel, selective and potent leukotriene B4 (LTB4) receptor antagonist. In vitro, CP-105696 inhibited [3H]LTB4 (0.3 nM) binding to hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd7aebb93b0e2bcbd787a491322865ea
https://pubmed.ncbi.nlm.nih.gov/7714764
https://pubmed.ncbi.nlm.nih.gov/7714764
Publikováno v:
Clinical reviews in allergy. 12(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2489cd62c2b6dd968b66eb0119c14d
https://pubmed.ncbi.nlm.nih.gov/7743461
https://pubmed.ncbi.nlm.nih.gov/7743461
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 255(2)
Lungs from guinea pigs passively sensitized with an affinity-purified IgG1 antibody produce both leukotriene (LT)D4 and thromboxane (Tx)B2 upon ex vivo antigen challenge. This study was undertaken to determine the possibility of endogenously generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d81921fbced3514b99bf21b2e060aa4b
https://pubmed.ncbi.nlm.nih.gov/2243346
https://pubmed.ncbi.nlm.nih.gov/2243346