Zobrazeno 1 - 10 of 16 pro vyhledávání: '"M. J. Betts"'
1
Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata
Autor: Susan Duty, Paul J. Austin, M. J. Betts, M. Broadstock
Publikováno v: British Journal of Pharmacology. 165:1034-1045
BACKGROUND AND PURPOSE Increased firing of the glutamatergic pathway between the subthalamic nucleus and substantia nigra pars reticulata (SNpr) contributes to the abnormal firing of motor circuits and subsequent motor deficits seen in Parkinson's di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0da9702aec6837ca9bc0d4112d11dcf
https://doi.org/10.1111/j.1476-5381.2011.01515.x
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2
Symptomatic and neuroprotective effects following activation of nigral group III metabotropic glutamate receptors in rodent models of Parkinson's disease
Autor: Michael J. O'Neill, M. Broadstock, S. N. Mitchell, Susan Duty, Paul J. Austin, M. J. Betts
Publikováno v: British Journal of Pharmacology. 160:1741-1753
Background and purpose: Increased glutamatergic innervation of the substantia nigra pars reticulata (SNpr) and pars compacta (SNpc) may contribute to the motor deficits and neurodegeneration, respectively, in Parkinson's disease (PD). This study aime
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebba0aa4587cbe1b2fb5512b41d76efa
https://doi.org/10.1111/j.1476-5381.2010.00820.x
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3
Synthesis and structure-activity relationships of new cephalosporins with aminoimidazoles at C-7. Effect of the pKa of the C-7 aminoimidazole on antibacterial spectrum and .BETA.-lactamase stability
Autor: G. M. Davies, A. Olivier, F. Jung, J. F. Kingston, J. D. Pittam, D. Boucherot, M. Joseph, C. Delvare, R. Brown, M. J. Betts, R. Stevenson
Publikováno v: The Journal of Antibiotics. 46:992-1012
Cephalosporins with new aminoimidazole heterocycles at C-7 have been synthesized by reaction of anti-alpha-aminooximes with C-7 dihaloisocyanocephalosporins esters or by direct condensation of 2-fluoroimidazoles with C-7 aminocephalosporins esters. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347e5bd9cd8900cbcdf0266228486805
https://doi.org/10.7164/antibiotics.46.992
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6
Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and .beta.-lactamase stability on the pKa of the C-7 heterocycle
Autor: N. Ackerley, C. Delvare, A. Hamon, D. Boucherot, F. Jung, M. J. Betts
Publikováno v: Journal of Medicinal Chemistry. 34:1110-1116
Cephalosporins with new aminobenzimidazole and aminoimidazoline heterocycles at C-7 have been synthesized starting with versatile C-7 isocyanide dihalide synthons. The aminobenzimidazoles have a broad spectrum of antibacterial activity, including Gra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a92e4b203e0f2978585af4ba25ed73d
https://doi.org/10.1021/jm00107a035
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