Zobrazeno 1 - 10
of 10
pro vyhledávání: '"M. J. Bawden"'
Publikováno v:
Journal of Inherited Metabolic Disease. 30:358-364
Mucopolysaccharidosis IIIB, an autosomal recessive lysosomal storage disorder of heparan sulfate caused by mutations in the alpha-N-acetylglucosaminidase (NAGLU) gene, was recently discovered in cattle. Clinical signs include progressive ataxia, stum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b734db6d1fd5c9441dafb81d0f3c730e
https://doi.org/10.1007/s10545-007-0539-5
https://doi.org/10.1007/s10545-007-0539-5
Publikováno v:
The Journal of biological chemistry. 267(26)
Erythroid 5-aminolevulinate synthase (ALAS) is expressed exclusively in differentiating erythroid cells as the principal isoform of the enzyme to catalyze the first step of the heme biosynthetic pathway. The human gene encoding this isozyme was isola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b3657be5125da540f70660a965f2378
https://pubmed.ncbi.nlm.nih.gov/1527005
https://pubmed.ncbi.nlm.nih.gov/1527005
Publikováno v:
Molecular biologymedicine. 7(5)
All nucleated animal cells synthesize heme to provide the prosthetic group of respiratory cytochromes. Large amounts of heme are synthesized by erythroid cells for hemoglobin production and by liver cells for drug-induced cytochromes P450. This revie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4264ffd41de6e80e29d5efee5e8413ac
https://pubmed.ncbi.nlm.nih.gov/2095458
https://pubmed.ncbi.nlm.nih.gov/2095458
Publikováno v:
Molecular pharmacology. 38(4)
The levels of hepatic mRNAs for several enzymes involved in drug metabolism were measured following administration to rats of either phenobarbitone or 2-allyl-2-isopropylacetamide. There was a substantial elevation in the mRNA levels for cytochromes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e68d3c84ad010e1268499e11a49aa8c1
https://pubmed.ncbi.nlm.nih.gov/2233690
https://pubmed.ncbi.nlm.nih.gov/2233690
Autor:
T C, Cox, M J, Bawden, N G, Abraham, S S, Bottomley, B K, May, E, Baker, L Z, Chen, G R, Sutherland
Publikováno v:
American journal of human genetics. 46(1)
The gene for erythroid 5-aminolevulinate synthase has been mapped to Xpter-Xq26 by Southern blot hybridization analysis of a mouse/human hybrid cell panel. In situ hybridization maps the gene to Xp21-Xq21, with the most likely location being on band
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3faa09a632727203498ec62b7a18b328
https://pubmed.ncbi.nlm.nih.gov/2294742
https://pubmed.ncbi.nlm.nih.gov/2294742
Autor:
Cornelis J. Elferink, D. J. Maguire, Gopesh Srivastava, Brian K. May, J. F B Mercer, M. J. Bawden, Iain A. Borthwick
Publikováno v:
Journal of Biological Chemistry. 263:5202-5209
cDNA clones for rat liver 5-aminolevulinate synthase have been isolated and used to examine mRNA levels in different rat tissues. Northern hybridization analysis of total RNA from various rat tissues showed the presence of a single 5-aminolevulinate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1f129b81292bcad4a67b790daa085a7
https://doi.org/10.1016/s0021-9258(18)60700-8
https://doi.org/10.1016/s0021-9258(18)60700-8
Autor:
G, Srivastava, I A, Borthwick, D J, Maguire, C J, Elferink, M J, Bawden, J F, Mercer, B K, May
Publikováno v:
The Journal of biological chemistry. 263(11)
cDNA clones for rat liver 5-aminolevulinate synthase have been isolated and used to examine mRNA levels in different rat tissues. Northern hybridization analysis of total RNA from various rat tissues showed the presence of a single 5-aminolevulinate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::94bb40760c419be17d1a03f099483642
https://pubmed.ncbi.nlm.nih.gov/3356687
https://pubmed.ncbi.nlm.nih.gov/3356687
Publikováno v:
Biochemical Society symposium. 55
Exposure of animals to foreign chemicals results in the induction of many enzymes. The mitochondrial enzyme 5-aminolaevulinate synthase (ALV-S) is induced to supply haem for cytochrome P-450 (P-450) enzymes, the key proteins in drug detoxification. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90a53be1663231093726a6486ee9de31
https://pubmed.ncbi.nlm.nih.gov/2619765
https://pubmed.ncbi.nlm.nih.gov/2619765
Autor:
B K, May, M J, Bawden
Publikováno v:
Seminars in hematology. 26(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c177085c850ca275a509e9235e36fb6
https://pubmed.ncbi.nlm.nih.gov/2658090
https://pubmed.ncbi.nlm.nih.gov/2658090
Publikováno v:
Extracellular Enzymes of Microorganisms ISBN: 9781468412765
B. amyloliquefaciens produces large amounts of two major secretory proteases: alkaline protease and neutral protease. Protease production by this organism is very unusual in its response to inhibitors of transcription. Using the antibiotics rifampici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8431847dee2af226fe27122e1f8e7f9d
https://doi.org/10.1007/978-1-4684-1274-1_11
https://doi.org/10.1007/978-1-4684-1274-1_11
