HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma

Autor: J. Contenti, Y. Guo, M. Larcher, L. Mirabal-Ortega, M. Rouleau, M. Irondelle, V. Tiroille, A. Mazzu, V. Duranton-Tanneur, F. Pedeutour, I. Ben-Sahra, C. Lago, G. Leva, L. Tiberi, G. Robert, C. Pouponnot, F. Bost, N. M. Mazure

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)

Abstract Medulloblastoma (MB) is the most prevalent brain cancer in children. Four subgroups of MB have been identified; of these, Group 3 is the most metastatic. Its genetics and biology remain less clear than the other groups, and it has a poor pro

Externí odkaz: https://doaj.org/article/6b0946adfba14408a97ab70bf63ae8b8

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Author Reply to Peer Reviews of Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and resistance in melanoma

Autor: S. Tartare-Deckert, B. Mari, M. Deckert, J.-C. Marine, G. Vassaux, F. Larbret, I. Berestjuk, A. Carminati, M. Couralet, M. Truchi, C. Mounier, M. Irondelle, C. Lacoux, L. Lefevre, C.A. Girard, O. Marin-Bejar, M. Lecacheur, J. Fassy, A. Baeri, S. Diazzi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a82941846b666e71b66fd7fbc95221f
https://doi.org/10.15252/rc.2022787505

UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

Autor: S Torrino, V Tiroille, B Dolfi, M Dufies, C Hinault, L Bonesso, S Dagnino, JP Uhler, M Irondelle, AS Gay, L Fleuriot, D Debayle, S Lacas-Gervais, M Cormont, T Bertero, F Bost, J Gilleron, S Clavel

Publikováno v: eLife
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/elife.68348⟩
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.68348⟩
eLife, 2021, 10, ⟨10.7554/elife.68348⟩
eLife, Vol 10 (2021)
eLife, 2021, 10, ⟨10.7554/eLife.68348⟩

To adapt in an ever-changing environment, cells must integrate physical and chemical signals and translate them into biological meaningful information through complex signaling pathways. By combining lipidomic and proteomic approaches with functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c063746d57ffb3738310b2b4cb7ce585
https://hal.archives-ouvertes.fr/hal-03408303/file/elife-68348-v2.pdf

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