Zobrazeno 1 - 10
of 56
pro vyhledávání: '"M. Inmaculada Barrasa"'
Autor:
Danielle L. Tomasello, M. Inmaculada Barrasa, David Mankus, Katia I. Alarcon, Abigail K. R. Lytton-Jean, X. Shawn Liu, Rudolf Jaenisch
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-27 (2024)
Abstract Studies on MECP2 function and its implications in Rett Syndrome (RTT) have traditionally centered on neurons. Here, using human embryonic stem cell (hESC) lines, we modeled MECP2 loss-of-function to explore its effects on astrocyte (AST) dev
Externí odkaz:
https://doaj.org/article/504471da9d3c4319ac418eab244a6290
Autor:
Alexsia Richards, Max Friesen, Andrew Khalil, M. Inmaculada Barrasa, Lee Gehrke, Rudolf Jaenisch
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105146- (2022)
Summary: Although respiratory symptoms are the most prevalent disease manifestation of infection by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), infection can also damage other organs, including the brain, gut, and liver. Symptoms of
Externí odkaz:
https://doaj.org/article/6fe950a3bccd498c9cd42bb4b1a67f54
Autor:
Liguo Zhang, Punam Bisht, Anthony Flamier, M. Inmaculada Barrasa, Max Friesen, Alexsia Richards, Stephen H. Hughes, Rudolf Jaenisch
Publikováno v:
Viruses, Vol 15, Iss 3, p 629 (2023)
SARS-CoV-2 sequences can be reverse-transcribed and integrated into the genomes of virus-infected cells by a LINE1-mediated retrotransposition mechanism. Whole-genome sequencing (WGS) methods detected retrotransposed SARS-CoV-2 subgenomic sequences i
Externí odkaz:
https://doaj.org/article/52c8cc1cbfb84c2dafca1dbb29c0f082
Autor:
Priyanka Narayan, Grzegorz Sienski, Julia M. Bonner, Yuan-Ta Lin, Jinsoo Seo, Valeriya Baru, Aftabul Haque, Blerta Milo, Leyla A. Akay, Agnese Graziosi, Yelena Freyzon, Dirk Landgraf, William R. Hesse, Julie Valastyan, M. Inmaculada Barrasa, Li-Huei Tsai, Susan Lindquist
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108224- (2020)
Summary: The ε4 allele of apolipoprotein E (APOE4) is a genetic risk factor for many diseases, including late-onset Alzheimer’s disease (AD). We investigate the cellular consequences of APOE4 in human iPSC-derived astrocytes, observing an endocyti
Externí odkaz:
https://doaj.org/article/371d6e17de3e4dcca3170e73f880da3a
Autor:
Valmik K. Vyas, G. Guy Bushkin, Douglas A. Bernstein, Matthew A. Getz, Magdalena Sewastianik, M. Inmaculada Barrasa, David P. Bartel, Gerald R. Fink
Publikováno v:
mSphere, Vol 3, Iss 2 (2018)
ABSTRACT We have created new vectors for clustered regularly interspaced short palindromic repeat (CRISPR) mutagenesis in Candida albicans, Saccharomyces cerevisiae, Candida glabrata, and Naumovozyma castellii. These new vectors permit a comparison o
Externí odkaz:
https://doaj.org/article/fc3e689ff07143b294c2db074a0e1a1e
Autor:
Robert A. Weinberg, David Pépin, Anniina Farkkila, Benjamin G. Neel, Paula T. Hammond, Shailja Pathania, Pamoda M. Galhenage, Jaana Oikkonen, Johanna Hynninen, Kaisa Huhtinen, Fernando Pérez-Villatoro, George W. Bell, M. Inmaculada Barrasa, Marie-Charlotte Meinsohn, Julia Casado, Bimarzhan Assatova, Esmee Hoefsmit, Ferenc Reinhardt, Sean G. Smith, Heiko Horn, Simge Yucel, Shuang Zhang, Sonia Iyer
Despite advances in immuno-oncology, the relationship between tumor genotypes and response to immunotherapy remains poorly understood, particularly in high-grade serous tubo-ovarian carcinomas (HGSC). We developed a series of mouse models that carry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03903dbf1cead4fa599c26374a273b2b
https://doi.org/10.1158/2159-8290.c.6548069.v1
https://doi.org/10.1158/2159-8290.c.6548069.v1
Autor:
Danielle L Tomasello, M. Inmaculada Barrasa, David Mankus, Katia I Alarcon, Abigail KR Lytton-Jean, X. Shawn Liu, Rudolf Jaenisch
Studies on the function of Methyl CpG binding protein 2 (MECP2) and the consequence ofMECP2deficiency and duplication have largely focused on neurons. The function of MECP2 in human glia, along with the comprehensive understanding of glial function i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86da04c165764ddbcd721c8d09782932
https://doi.org/10.1101/2023.03.02.530903
https://doi.org/10.1101/2023.03.02.530903
Autor:
Max Friesen, Andrew S. Khalil, M. Inmaculada Barrasa, Jacob F. Jeppesen, David J. Mooney, Rudolf Jaenisch
Publikováno v:
Science Advances. 8
Adipocytes are key regulators of human metabolism, and their dysfunction in insulin signaling is central to metabolic diseases including type II diabetes mellitus (T2D). However, the progression of insulin resistance into T2D is still poorly understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa81c4fd8db6281b1873a8cc5caf6e60
https://doi.org/10.1126/sciadv.abn7298
https://doi.org/10.1126/sciadv.abn7298
Autor:
Alexsia Richards, Max Friesen, Andrew Khalil, M. Inmaculada Barrasa, Lee Gehrke, Rudolf Jaenisch
Publikováno v:
iScience. 25(10)
Although respiratory symptoms are the most prevalent disease manifestation of infection by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), infection can also damage other organs, including the brain, gut, and liver. Symptoms of liver da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb099438e3c767e8fbe796c4a2d00414
https://pubmed.ncbi.nlm.nih.gov/36128218
https://pubmed.ncbi.nlm.nih.gov/36128218
Autor:
Richard A. Young, Stephen H. Hughes, M. Inmaculada Barrasa, Alexsia Richards, Rudolf Jaenisch, Liguo Zhang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
In our paper (1), we draw two major conclusions. [↵][1] 1To whom correspondence may be addressed. Email: jaenisch{at}wi.mit.edu. [1]: #xref-corresp-1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61892414c9fea1fbf81814837184dbca
https://pubmed.ncbi.nlm.nih.gov/34702741
https://pubmed.ncbi.nlm.nih.gov/34702741