Výsledky vyhledávání - "M. I. Kachaeva"

Evaluation of antiproliferative and apoptotic effects of the rational combination of the MEK1/2 inhibitor selumetinib (AZD6244) and inhibitors of the hedgehog pathway in colorectal cancer (CRC) cell lines

Autor: S. G. Eckhardt, Todd M. Pitts, Anna Spreafico, Heather M. Selby, John J. Tentler, Aik Choon Tan, M. I. Kachaeva

Publikováno v: Journal of Clinical Oncology. 29:422-422

422 Background: The MAPK pathway is a crucial regulator of cell proliferation, survival, and resistance to apoptosis. Hyperactivation of this pathway due to mutations in KRAS have been reported in up to 50% of CRC cases. Clinical trials have shown th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf10d6b021fff41cee4a27fbb727ba95
https://doi.org/10.1200/jco.2011.29.4_suppl.422

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