Výsledky vyhledávání - "M. I. Crespo"

Syntheses and biological evaluation of indole-2 and 3-carboxamides: new selective cyclooxygenase-2 inhibitors

Autor: S, Olgen, E, Güner, M A, Fabregat, M I, Crespo, D, Nebioğlu

Publikováno v: Die Pharmazie. 57(4)

A series of indol-2 and 3-carboxamides were prepared and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1). Substitution on indol nitrogen with benzyl and p-fluorobenzyl group of indole-2 carboxamides 8, 10,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7f764558db7ee8ade071e5109feecb1
https://pubmed.ncbi.nlm.nih.gov/11998441

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Synthesis and biological evaluation of 2,5-dihydropyrazol

Autor: M I, Crespo, J, Gràcia, C, Puig, A, Vega, J, Bou, J, Beleta, T, Doménech, H, Ryder, V, Segarra, J M, Palacios

Publikováno v: Bioorganicmedicinal chemistry letters. 10(23)

A novel series of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones has been prepared. These compounds showed good PDE 4 inhibitory activity and weak affinity for rolipram's binding site. They also exhibited a good anti-inflammatory profile without emetic si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b252926ee90e2624bad7a3bb1c527a6
https://pubmed.ncbi.nlm.nih.gov/11128646

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Design and QSAR of Dihydropyrazolo[4,3-c]Quinolinones as PDE4 Inhibitors

Autor: V. Segarra, J. Beleta, M. I. Crespo, J. M. Palacios, M. López, T. Domenech, H. Ryder, J. Gràcia

Publikováno v: Molecular Modeling and Prediction of Bioactivity ISBN: 9781461368571

The interest in therapeutic utility of PDE inhibitors is mostly focused on new agents which selectively inhibit the PDE4 family1. This subtype of phosphodiesterase is found in both respiratory smooth muscle and circulatory inflammatory cells. Its inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d53b796b6ec019933ca872b34e760b5a
https://doi.org/10.1007/978-1-4615-4141-7_48

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