Harnessing PROTAC technology to combat stress hormone receptor activation

Autor: Mahshid Gazorpak, Karina M. Hugentobler, Dominique Paul, Pierre-Luc Germain, Miriam Kretschmer, Iryna Ivanova, Selina Frei, Kei Mathis, Remo Rudolf, Sergio Mompart Barrenechea, Vincent Fischer, Xiaohan Xue, Aleksandra L. Ptaszek, Julian Holzinger, Mattia Privitera, Andreas Hierlemann, Onno C. Meijer, Robert Konrat, Erick M. Carreira, Johannes Bohacek, Katharina Gapp

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)

Abstract Counteracting the overactivation of glucocorticoid receptors (GR) is an important therapeutic goal in stress-related psychiatry and beyond. The only clinically approved GR antagonist lacks selectivity and induces unwanted side effects. To co

Externí odkaz: https://doaj.org/article/a28a8f76999f4d2694653264846e8de2

Discovery and Surprises with Cyclizations, Cycloadditions, Fragmentations, and Rearrangements in Complex Settings

Autor: Erick M. Carreira, Karina M Hugentobler

Publikováno v: Accounts of chemical research. 54(4)

We discuss a number of synthesis routes to complex natural products recently reported from our group. Although the structures are quite varied, we demonstrate the research endeavor as a setting to examine the implementation of cyclizations, cycloaddi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f941949603f492eb7203cf1dd14ebba
https://pubmed.ncbi.nlm.nih.gov/33533583

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Application of the European Test of Olfactory Capabilities in patients with olfactory impairment

Autor: M. Bessy, F. Faure, Catherine Rouby, Pierre Krolak-Salmon, Basile Nicolas Landis, Hely Tuorila, Moustafa Bensafi, M. Hugentobler, Seija Vento, Floriane Delphin-Combe, D. Bellil, Sari Mustonen, Pauline Joussain

Publikováno v: European Archives of Oto-Rhino-Laryngology
European Archives of Oto-Rhino-Laryngology, Springer Verlag, 2016, 273 (2), pp.381-390. ⟨10.1007/s00405-015-3536-6⟩
Europe PubMed Central

A central issue in olfaction concerns the characterization of loss of olfactory function: partial (hyposmia) or total (anosmia). This paper reports the application in a clinical setting of the European Test of Olfactory Capabilities (ETOC), combining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a58af64a4be7cb4ab6393f6f908992
https://hal.archives-ouvertes.fr/hal-02343704

Morphology and stability of Au nanoclusters in HOPG nanopits of well defined depth

Autor: S. Bonanni, M. Hugentobler, A. Sautier, W. Harbich

Publikováno v: EPJD

Gold nanoparticles with a diameter comprised between 4 and 6 nm are stabilized in nanosized pits of well defined depth in highly oriented pyrolytic graphite (HOPG). These pits are produced by creation of artificial defects, followed by etching under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f760a4c5e84ea680c6c5e801664ec9cf