Zobrazeno 1 - 10
of 2 476
pro vyhledávání: '"M. Hsieh"'
Autor:
Vadim Osadchiy, Andre Belarmino, Reza Kianian, John T. Sigalos, Jacob S. Ancira, Trisha Kanie, Sarah F. Mangum, Craig D. Tipton, Tung-Chin M. Hsieh, Jesse N. Mills, Sriram V. Eleswarapu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract There has recently been an explosion of studies implicating the human microbiome in playing a critical role in many disease and wellness states. The etiology of abnormal semen analysis (SA) parameters is not identified in 30% of cases; inves
Externí odkaz:
https://doaj.org/article/29e4681c55a446b89804279f13d5abb8
Autor:
Alexis Leonard, Morgan Yapundich, Tina Nassehi, Jackson Gamer, Claire M. Drysdale, Juan J. Haro-Mora, Selami Demirci, Matthew M. Hsieh, Naoya Uchida, John F. Tisdale
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 430-437 (2019)
Humanized animal models are central to efforts aimed at improving hematopoietic stem cell (HSC) transplantation with or without genetic modification. Human cell engraftment is feasible in immunodeficient mice; however, high HSC doses and conditioning
Externí odkaz:
https://doaj.org/article/6db86d5a7bf54e228d1925acc5c5fa51
Autor:
Jean-Yves Métais, Phillip A. Doerfler, Thiyagaraj Mayuranathan, Daniel E. Bauer, Stephanie C. Fowler, Matthew M. Hsieh, Varun Katta, Sagar Keriwala, Cicera R. Lazzarotto, Kevin Luk, Michael D. Neel, S. Scott Perry, Samuel T. Peters, Shaina N. Porter, Byoung Y. Ryu, Akshay Sharma, Devlin Shea, John F. Tisdale, Naoya Uchida, Scot A. Wolfe, Kaitly J. Woodard, Yuxuan Wu, Yu Yao, Jing Zeng, Shondra Pruett-Miller, Shengdar Q. Tsai, Mitchell J. Weiss
Publikováno v:
Blood Advances, Vol 3, Iss 21, Pp 3379-3392 (2019)
Abstract: Induction of fetal hemoglobin (HbF) via clustered regularly interspaced short palindromic repeats/Cas9–mediated disruption of DNA regulatory elements that repress γ-globin gene (HBG1 and HBG2) expression is a promising therapeutic strate
Externí odkaz:
https://doaj.org/article/d8bdc8c4db524cf3ab90d0385b570174
Autor:
Naoya Uchida, Matthew M. Hsieh, Lydia Raines, Juan J. Haro-Mora, Selami Demirci, Aylin C. Bonifacino, Allen E. Krouse, Mark E. Metzger, Robert E. Donahue, John F. Tisdale
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Vectors used in gene therapy for hemoglobin disorders carry globin in a reverse-orientation to prevent the loss of key regulatory elements by RNA splicing, but this limits their efficiency. Here, the authors develop a vector carrying β-globin in a f
Externí odkaz:
https://doaj.org/article/10b9f0823d304489858931b8d82f9d3e
Autor:
Naoya Uchida, Tina Nassehi, Claire M. Drysdale, Jackson Gamer, Morgan Yapundich, Selami Demirci, Juan J. Haro-Mora, Alexis Leonard, Matthew M. Hsieh, John F. Tisdale
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 187-196 (2019)
Hematopoietic stem cell (HSC) gene therapy is curative for various hereditary diseases; however, high-efficiency transduction in HSCs remains crucial to improve the prospects for hemoglobinopathies. We previously optimized lentiviral transduction in
Externí odkaz:
https://doaj.org/article/bad1b67ab3294837b7e23c9ec3e25b24
Autor:
Robert Sheppard Nickel, Willy A. Flegel, Sharon D. Adams, Jeanne E. Hendrickson, Hua Liang, John F. Tisdale, Matthew M. Hsieh
Publikováno v:
EClinicalMedicine, Vol 24, Iss , Pp 100432- (2020)
Background: Hematopoietic stem cell transplantation (HSCT) is curative for patients with sickle cell disease (SCD). Prior to HSCT, patients with SCD commonly receive RBC transfusions with some becoming RBC or HLA alloimmunized. This alloimmunization
Externí odkaz:
https://doaj.org/article/9882aec95c17417daa80e09e80878a99
Autor:
Ling-Hsiu Liao, Daniel J Pearlstein, Wen-Yen Wu, Allison G Kelley, William M Montag, Edward M Hsieh, May R Berenbaum
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243364 (2020)
For the past decade, migratory beekeepers who provide honey bees for pollination services have experienced substantial colony losses on a recurring basis that have been attributed in part to exposure to insecticides, fungicides, or their combinations
Externí odkaz:
https://doaj.org/article/04b57c208b10465bad18483625e6c6c1
Autor:
Brisa M. Hsieh, Alicia K. Beets
Publikováno v:
Frontiers in Veterinary Science, Vol 6 (2020)
Cough is one of the most common complaints in human medicine. In veterinary medicine cough is equally frequent and plays a significant role in an owner's perception of their pet's quality of life. In human and veterinary medicine, therapy for chronic
Externí odkaz:
https://doaj.org/article/f85ac43ad3c64ca6821ebcd39c9cca03
Autor:
Naoya Uchida, Selami Demirci, Juan J. Haro-Mora, Atsushi Fujita, Lydia N. Raines, Matthew M. Hsieh, John F. Tisdale
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 247-256 (2018)
In vitro erythroid differentiation from primary human cells is valuable to develop genetic strategies for hemoglobin disorders. However, current erythroid differentiation methods are encumbered by modest transduction rates and high baseline fetal hem
Externí odkaz:
https://doaj.org/article/36b473ce1996481989274e0c3f7ae7cf
Autor:
Paul M. Luethy, Sean C. Murphy, Annette M. Seilie, Yingda L. Xie, Chuen-Yen Lau, John F. Tisdale, Matthew M. Hsieh, Jessica L. Reinhardt, Anna F. Lau, Gary A. Fahle
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-5 (2018)
Abstract Background Autosplenectomy, as a result of sickle cell disease, is an important risk factor for severe malaria. While molecular methods are helpful in providing rapid and accurate infection detection and species identification, the effect of
Externí odkaz:
https://doaj.org/article/c337a5a445c34c41b636e16d1da824ce