The Decrease in Serum sRAGE Levels Upon Smoking is Associated with Activated Neutrophils

Autor: Valerie R. Wiersma, Susan J. M. Hoonhorst, Nick H. T. ten Hacken, Maarten van den Berge, Dirk-Jan Slebos, Simon D. Pouwels

Publikováno v: Lung, 200. SPRINGER

The serum level of the soluble Receptor for Advanced Glycation End-products (sRAGE) is a promising blood biomarker for the development, severity, and progression of chronic obstructive pulmonary disease (COPD). However, cigarette smoking causes a nea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12eadffd7f055c7ed54da593281936e
https://pubmed.ncbi.nlm.nih.gov/36282357

Lower corticosteroid skin blanching response is associated with severe COPD.

Autor: Susan J M Hoonhorst, Nick H T ten Hacken, Adèle T Lo Tam Loi, Leo Koenderman, Jan Willem J Lammers, Eef D Telenga, H Marike Boezen, Maarten van den Berge, Dirkje S Postma

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e91788 (2014)

Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation caused by ongoing inflammatory and remodeling processes of the airways and lung tissue. Inflammation can be targeted by corticosteroids. However, airway infla

Externí odkaz: https://doaj.org/article/497654784fb74750af3b1afc50cefe62

Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression

Autor: Katrina Steiling, Marc E. Lenburg, J. Sebastiaan Vroegop, Ilse M. Boudewijn, Marnix R. Jonker, Pascal Wielders, Victor Guryev, Irene H. Heijink, Huib A. M. Kerstjens, Maarten van den Berge, Erica van der Wiel, Susan J. M. Hoonhorst, Eef D. Telenga, Nick H. T. ten Hacken, Corry-Anke Brandsma, Khaled Mansour, Alen Faiz, Dirkje S. Postma, Wim Timens, Wim Boersma, Harold G. de Bruin, Avrum Spira, Henk R. Pasma, Frank van den Elshout

Publikováno v: Respiratory Research, 18:213. BioMed Central Ltd.
Respiratory Research, Vol 18, Iss 1, Pp 1-10 (2017)
Respiratory Research

Nasal gene expression profiling is a promising method to characterize COPD non-invasively. We aimed to identify a nasal gene expression profile to distinguish COPD patients from healthy controls. We investigated whether this COPD-associated gene expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dbc0ee6e3bd008c968d924b9ad8984
https://hdl.handle.net/10453/128484

Proteomic profiling of peripheral blood neutrophils identifies two inflammatory phenotypes in stable COPD patients

Autor: Corneli van Aalst, Adèle Lo Tam Loi, Simone Sluis-Eising, Susan J. M. Hoonhorst, Vera M. Kamp, Nick H. T. ten Hacken, Leo Koenderman, Jeroen D. Langereis, Jan-Willem J. Lammers

Publikováno v: Respiratory Research
Respiratory Research, 18, 100
Respiratory Research, 18(100). BioMed Central Ltd.
Respiratory Research, Vol 18, Iss 1, Pp 1-13 (2017)
Respiratory Research, 18, 1, pp. 100

Contains fulltext : 177455.pdf (Publisher’s version ) (Open Access) BACKGROUND: COPD is a heterogeneous chronic inflammatory disease of the airways and it is well accepted that the GOLD classification does not fully represent the complex clinical m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2f8d1426c3c8ee6e98cdd6ee6093c5
http://europepmc.org/articles/PMC5440930

Advanced glycation end products in the skin are enhanced in COPD

Autor: Jorine E. Hartman, H. Marike Boezen, Adèle T. Lo Tam Loi, Eef D. Telenga, Leo Koenderman, Jan Willem J. Lammers, Susan J. M. Hoonhorst, Nick H. T. ten Hacken, Maarten van den Berge, Dirkje S. Postma

Publikováno v: Metabolism, 63(9), 1149-1156. W B SAUNDERS CO-ELSEVIER INC

Background. Cigarette smoking is the main cause of chronic obstructive pulmonary disease (COPD) inducing oxidative stress and local tissue injury, resulting in pulmonary inflammation. Advanced glycation end products (AGEs) are produced by glycation a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11590e981656c071e824c172d87c410b
https://doi.org/10.1016/j.metabol.2014.06.006