Zobrazeno 1 - 10
of 8 825
pro vyhledávání: '"M. Heine"'
Autor:
Kevin L. Batenburg, Claudia Sestito, Paulien Cornelissen-Steijger, Jan R. T. van Weering, Leo S. Price, Vivi M. Heine, Wiep Scheper
Publikováno v:
Biological Procedures Online, Vol 25, Iss 1, Pp 1-14 (2023)
Abstract Background Intraneuronal tau aggregation is the major pathological hallmark of neurodegenerative tauopathies. It is now generally acknowledged that tau aggregation also affects astrocytes in a cell non-autonomous manner. However, mechanisms
Externí odkaz:
https://doaj.org/article/dc48a5e9b803420cb8bd12454e349851
Autor:
David R. Garcia Castro, Joseph R. Mazuk, Erin M. Heine, Daniel Simpson, R. Seth Pinches, Caroline Lozzi, Kathryn Hoffman, Phillip Morrin, Dylan Mathis, Maria V. Lebedev, Elyse Nissley, Kang Hoo Han, Tyler Farmer, Diane E. Merry, Qiang Tong, Maria Pennuto, Heather L. Montie
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107375- (2023)
Summary: Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease with substantial mitochondrial and metabolic dysfunctions. SBMA is caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Activating or increasing the NAD
Externí odkaz:
https://doaj.org/article/0ad1fa7b373a453e989aeb3538dcebdf
Autor:
Anne E.J. Hillen, Martina Hruzova, Tanja Rothgangl, Marjolein Breur, Marianna Bugiani, Marjo S. van der Knaap, Gerald Schwank, Vivi M. Heine
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 17-25 (2022)
Vanishing white matter (VWM) is a leukodystrophy caused by recessive variants in subunits of eIF2B. At present, no curative treatment is available and patients often die at young age. Due to its monogenic nature, VWM is a promising candidate for the
Externí odkaz:
https://doaj.org/article/d51fbd1fddf8449885eaa46a547d3024
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The biomechanical properties of the brain microenvironment, which is composed of different neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain development and neural functioning. Stiffness, viscoelasticity an
Externí odkaz:
https://doaj.org/article/54ec355531124ff68000b47dd09865c3
Publikováno v:
Rivista Internazionale di Scienze Sociali e Discipline Ausiliarie, 1922 Dec 01. 94(360), 348-349.
Externí odkaz:
https://www.jstor.org/stable/41612317
Publikováno v:
The Military Engineer, 1942 Dec 01. 34(206), 652-652.
Externí odkaz:
https://www.jstor.org/stable/44567006
Autor:
C. Lehr, F. Wamers, F. Aksouh, Yu. Aksyutina, H. Álvarez-Pol, L. Atar, T. Aumann, S. Beceiro-Novo, C.A. Bertulani, K. Boretzky, M.J.G. Borge, C. Caesar, M. Chartier, A. Chatillon, L.V. Chulkov, D. Cortina-Gil, P. Díaz Fernández, H. Emling, O. Ershova, L.M. Fraile, H.O.U. Fynbo, D. Galaviz, H. Geissel, M. Heil, M. Heine, D.H.H. Hoffmann, M. Holl, H.T. Johansson, B. Jonson, C. Karagiannis, O.A. Kiselev, J.V. Kratz, R. Kulessa, N. Kurz, C. Langer, M. Lantz, T. Le Bleis, R. Lemmon, Yu.A. Litvinov, B. Löher, K. Mahata, J. Marganiec-Galązka, C. Müntz, T. Nilsson, C. Nociforo, W. Ott, V. Panin, S. Paschalis, A. Perea, R. Plag, R. Reifarth, A. Richter, K. Riisager, C. Rodriguez-Tajes, D. Rossi, D. Savran, H. Scheit, G. Schrieder, P. Schrock, H. Simon, J. Stroth, K. Sümmerer, O. Tengblad, H. Weick, C. Wimmer
Publikováno v:
Physics Letters B, Vol 827, Iss , Pp 136957- (2022)
The proton drip-line nucleus 17Ne is investigated experimentally in order to determine its two-proton halo character. A fully exclusive measurement of the 17Ne(p,2p)16F→15⁎O+p quasi-free one-proton knockout reaction has been performed at GSI at a
Externí odkaz:
https://doaj.org/article/c78af451b54e42e4974ebb4225bf3eeb
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-13 (2020)
Abstract Background Tuberous sclerosis complex (TSC) is a rare genetic multisystemic disorder resulting from autosomal dominant mutations in the TSC1 or TSC2 genes. It is characterised by hyperactivation of the mechanistic target of rapamycin complex
Externí odkaz:
https://doaj.org/article/2d5e00912a784374998241719343ff7e
Autor:
Josse A. Depla, Marina Sogorb-Gonzalez, Lance A. Mulder, Vivi M. Heine, Pavlina Konstantinova, Sander J. van Deventer, Katja C. Wolthers, Dasja Pajkrt, Adithya Sridhar, Melvin M. Evers
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 167-175 (2020)
The development of gene therapies for central nervous system disorders is challenging because it is difficult to translate preclinical data from current in vitro and in vivo models to the clinic. Therefore, we developed induced pluripotent stem cell
Externí odkaz:
https://doaj.org/article/6801bff942ae41f78c9545db8a90bbd9
Autor:
Danijela Drakulic, Srdjan Djurovic, Yasir Ahmed Syed, Sebastiano Trattaro, Nicolò Caporale, Anna Falk, Rivka Ofir, Vivi M. Heine, Samuel J. R. A. Chawner, Antonio Rodriguez-Moreno, Marianne B. M. van den Bree, Giuseppe Testa, Spyros Petrakis, Adrian J. Harwood
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-18 (2020)
Abstract Patients diagnosed with chromosome microdeletions or duplications, known as copy number variants (CNVs), present a unique opportunity to investigate the relationship between patient genotype and cell phenotype. CNVs have high genetic penetra
Externí odkaz:
https://doaj.org/article/d4e8450a48824f23b625b697df32b39b