Zobrazeno 1 - 10
of 505
pro vyhledávání: '"M. Havekes"'
Autor:
Sam J.L. van der Tuin, Susan Kühnast, Jimmy F.P. Berbée, Lars Verschuren, Elsbet J. Pieterman, Louis M. Havekes, José W.A. van der Hoorn, Patrick C.N. Rensen, J. Wouter Jukema, Hans M.G. Princen, Ko Willems van Dijk, Yanan Wang
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 11, Pp 2085-2093 (2015)
Recently, we showed in APOE*3-Leiden cholesteryl ester transfer protein (E3L.CETP) mice that anacetrapib attenuated atherosclerosis development by reducing (V)LDL cholesterol [(V)LDL-C] rather than by raising HDL cholesterol. Here, we investigated th
Externí odkaz:
https://doaj.org/article/703c44bd9c0c4c1b91d3e208489b298a
Autor:
Padmini P.S.J. Khedoe, Geerte Hoeke, Sander Kooijman, Wieneke Dijk, Jeroen T. Buijs, Sander Kersten, Louis M. Havekes, Pieter S. Hiemstra, Jimmy F.P. Berbée, Mariëtte R. Boon, Patrick C.N. Rensen
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 1, Pp 51-59 (2015)
Brown adipose tissue (BAT) produces heat by burning TGs that are stored within intracellular lipid droplets and need to be replenished by the uptake of TG-derived FA from plasma. It is currently unclear whether BAT takes up FA via uptake of TG-rich l
Externí odkaz:
https://doaj.org/article/f3b2d01a38d04a7389b7ab72af087a77
Autor:
Sander Kooijman, Mariëtte R. Boon, Edwin T. Parlevliet, Janine J. Geerling, Vera van de Pol, Johannes A. Romijn, Louis M. Havekes, Illiana Meurs, Patrick C.N. Rensen
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 2022-2032 (2014)
The melanocortin system is an important regulator of energy balance, and melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of obesity. We investigated whether the relationship between melanocortin system activity and energy
Externí odkaz:
https://doaj.org/article/1b0ca6cb4294435fa64980491e7d577b
Autor:
Janine J. Geerling, Mariëtte R. Boon, Sander Kooijman, Edwin T. Parlevliet, Louis M. Havekes, Johannes A. Romijn, Illiana M. Meurs, Patrick C.N. Rensen
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 2, Pp 180-189 (2014)
Important players in triglyceride (TG) metabolism include the liver (production), white adipose tissue (WAT) (storage), heart and skeletal muscle (combustion to generate ATP), and brown adipose tissue (BAT) (combustion toward heat), the collective ac
Externí odkaz:
https://doaj.org/article/22c9af50d84f4e3fa91da41d2927932a
Autor:
Thomas Gautier, Willeke de Haan, Jacques Grober, Dan Ye, Matthias J. Bahr, Thierry Claudel, Niels Nijstad, Theo J.C. Van Berkel, Louis M. Havekes, Michael P. Manns, Stefan M. Willems, Pancras C.W. Hogendoorn, Laurent Lagrost, Folkert Kuipers, Miranda Van Eck, Patrick C.N. Rensen, Uwe J.F. Tietge
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 8, Pp 2195-2205 (2013)
Cholesteryl ester transfer protein (CETP) activity results in a proatherogenic lipoprotein profile. In cholestatic conditions, farnesoid X receptor (FXR) signaling by bile acids (BA) is activated and plasma HDL cholesterol (HDL-C) levels are low. Thi
Externí odkaz:
https://doaj.org/article/70b732072eac42ef9a7951d48e70bab0
Autor:
Kanami Sugimoto-Kawabata, Hiroshi Shimada, Kaoru Sakai, Kazuo Suzuki, Thomas Kelder, Elsbet J. Pieterman, Louis H. Cohen, Louis M. Havekes, Hans M. Princen, Anita M. van den Hoek
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1255-1264 (2013)
Bile acid sequestrants (BASs) are cholesterol-lowering drugs that also affect hyperglycemia. The mechanism by which BASs exert these and other metabolic effects beyond cholesterol lowering remains poorly understood. The present study aimed to investi
Externí odkaz:
https://doaj.org/article/aef6254d56e24440b004893f7a2d5f51
Autor:
Janna A. van Diepen, Rinke Stienstra, Irene O. C.M. Vroegrijk, Sjoerd A.A. van den Berg, Daniela Salvatori, Guido J. Hooiveld, Sander Kersten, Cees J. Tack, Mihai G. Netea, Johannes W.A. Smit, Leo A.B. Joosten, Louis M. Havekes, Ko Willems van Dijk, Patrick C.N. Rensen
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 2, Pp 448-456 (2013)
Caspase-1 is known to activate the proinflammatory cytokines IL-1β and IL-18. Additionally, it can cleave other substrates, including proteins involved in metabolism. Recently, we showed that caspase-1 deficiency in mice strongly reduces high-fat di
Externí odkaz:
https://doaj.org/article/6e780bacf3b342febeb95866706387ee
Autor:
Carlos L.J. Vrins, Roelof Ottenhoff, Karin van den Oever, Dirk R. de Waart, J. Kar Kruyt, Ying Zhao, Theo J.C. van Berkel, Louis M. Havekes, Johannes M. Aerts, Miranda van Eck, Patrick C.N. Rensen, Albert K. Groen
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 10, Pp 2017-2023 (2012)
Transintestinal cholesterol efflux (TICE) provides an attractive target to increase body cholesterol excretion. At present, the cholesterol donor responsible for direct delivery of plasma cholesterol to the intestine is unknown. In this study, we inv
Externí odkaz:
https://doaj.org/article/699f266aedbf4186933a17a483e49497
Autor:
Claudia P. Coomans, Janine J. Geerling, Bruno Guigas, Anita M. van den Hoek, Edwin T. Parlevliet, D. Margriet Ouwens, Hanno Pijl, Peter J. Voshol, Patrick C.N. Rensen, Louis M. Havekes, Johannes A. Romijn
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 9, Pp 1712-1722 (2011)
Insulin signaling in the central nervous system (CNS) is required for the inhibitory effect of insulin on glucose production. Our aim was to determine whether the CNS is also involved in the stimulatory effect of circulating insulin on the tissue-spe
Externí odkaz:
https://doaj.org/article/e28774ae54384d0baefe6731789094a9
Autor:
Yanan Wang, Jimmy F.P. Berbée, Erik S. Stroes, Johannes W.A. Smit, Louis M. Havekes, Johannes A. Romijn, Patrick C.N. Rensen
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 8, Pp 1533-1541 (2011)
Human data suggest that reconstituted HDL (rHDL) infusion can induce atherosclerosis regression. Studies in mice indicated that rHDL infusion adversely affects VLDL levels, but this effect is less apparent in humans. This discrepancy may be explained
Externí odkaz:
https://doaj.org/article/44a44f64b8d94d30bf130024c70c02f9