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Development of [ ¹⁸ F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease.

Autor: Wong SW; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia., Vivash L; The Central Clinical School and The Alfred Hospital, Monash University, Melbourne, Victoria, Australia., Mudududdla R; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia., Nguyen N; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia., Hermans SJ; ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia., Shackleford DM; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia., Field J; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, 3010, Australia., Xue L; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia., Aprico A; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, 3010, Australia., Hancock NC; ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia., Haskali M; Centre for Molecular Imaging, Peter MacCallum Cancer Centre, Parkville, Victoria, 3052, Australia., Stashko MA; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States., Frye SV; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States., Wang X; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States., Binder MD; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, 3010, Australia; Department of Anatomy and Physiology, University of Melbourne, Parkville, Victoria, 3010, Australia., Ackermann U; Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, 3084, Australia., Parker MW; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, 3010, Australia; ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, 3065, Australia., Kilpatrick TJ; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, 3010, Australia; The Florey Department of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, 3010, Australia. Electronic address: tkilpat@florey.edu.au., Baell JB; School of Pharmaceutical Sciences, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing, 211816, People's Republic of China; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia. Electronic address: jonathan.baell@monash.edu.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2021 Dec 15; Vol. 226, pp. 113822. Date of Electronic Publication: 2021 Sep 04.