Zobrazeno 1 - 10
of 351
pro vyhledávání: '"M. Hartig be"'
Autor:
Sandra L. Grimm, Samuel Reddick, Xiaoyu Dong, Connor Leek, Amy Xiao Wang, Manuel Cantu Gutierrez, Sean M. Hartig, Bhagavatula Moorthy, Cristian Coarfa, Krithika Lingappan
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Bronchopulmonary dysplasia (BPD) is characterized by an arrest in lung development and is a leading cause of morbidity in premature neonates. It has been well documented that BPD disproportionally affects males compared to females
Externí odkaz:
https://doaj.org/article/b08c6f1bdb5049889cfae7c8a2b0788f
Autor:
Peter M Masschelin, Pradip Saha, Scott A Ochsner, Aaron R Cox, Kang Ho Kim, Jessica B Felix, Robert Sharp, Xin Li, Lin Tan, Jun Hyoung Park, Liping Wang, Vasanta Putluri, Philip L Lorenzi, Alli M Nuotio-Antar, Zheng Sun, Benny Abraham Kaipparettu, Nagireddy Putluri, David D Moore, Scott A Summers, Neil J McKenna, Sean M Hartig
Publikováno v:
eLife, Vol 12 (2023)
Flavin adenine dinucleotide (FAD) interacts with flavoproteins to mediate oxidation-reduction reactions required for cellular energy demands. Not surprisingly, mutations that alter FAD binding to flavoproteins cause rare inborn errors of metabolism (
Externí odkaz:
https://doaj.org/article/efada387f39b4eff8fe4ccda1c65b1f6
Autor:
Mi Jeong Heo, Ji Ho Suh, Sung Ho Lee, Kyle L. Poulsen, Yu A. An, Bhagavatula Moorthy, Sean M. Hartig, David D. Moore, Kang Ho Kim
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101717- (2023)
Objective: Mitophagy removes damaged mitochondria to maintain cellular homeostasis. Aryl hydrocarbon receptor (AhR) expression in the liver plays a crucial role in supporting normal liver functions, but its impact on mitochondrial function is unclear
Externí odkaz:
https://doaj.org/article/13b0b290b21c4a599188bb3f6154ef68
Autor:
Chung Hwan Hong, Myoung Seok Ko, Jae Hyun Kim, Hyunkyung Cho, Chi-Ho Lee, Ji Eun Yoon, Ji-Young Yun, In-Jeoung Baek, Jung Eun Jang, Seung Eun Lee, Yun Kyung Cho, Ji Yeon Baek, Soo Jin Oh, Bong Yong Lee, Joon Seo Lim, Jongkook Lee, Sean M. Hartig, Laura Conde de la Rosa, Carmen Garcia-Ruiz, Ki-Up Lee, Jose C. Fernández-Checa, Ji Woong Choi, Sanghee Kim, Eun Hee Koh
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 925-947 (2022)
Background & Aims: Sphingosine 1-phosphate receptors (S1PRs) are a group of G-protein–coupled receptors that confer a broad range of functional effects in chronic inflammatory and metabolic diseases. S1PRs also may mediate the development of nonalc
Externí odkaz:
https://doaj.org/article/9e46029d27bf4714b479e2ac2776f414
Autor:
Hua Mao, Luge Li, Qiying Fan, Aude Angelini, Pradip K. Saha, Huaizhu Wu, Christie M. Ballantyne, Sean M. Hartig, Liang Xie, Xinchun Pi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Type 2 diabetes is associated with chronic inflammation and is characterized by insulin resistance. Here, the authors identify a crucial role for endothelial BMPER function in glucose homeostasis, and BMPER overexpression was shown to alleviate insul
Externí odkaz:
https://doaj.org/article/955957e083474c468a00c6e9258ec4a1
Autor:
Neeti Agarwal, Claudia E. Ramirez Bustamante, Huaizhu Wu, Reina Armamento‐Villareal, Jordan E. Lake, Ashok Balasubramanyam, Sean M. Hartig
Publikováno v:
Physiological Reports, Vol 10, Iss 9, Pp n/a-n/a (2022)
Abstract Plasma biomarkers that reflect energy balance disorders in people living with HIV (PLWH) remain limited. Growth differentiation factor 15 (GDF15) abundance in plasma of mice and humans induces negative energy balance but also becomes highly
Externí odkaz:
https://doaj.org/article/d305955a3d7c4aa78b5e34a1362655a4
Autor:
Ayala Tovy, Jaime M Reyes, Linda Zhang, Yung-Hsin Huang, Carina Rosas, Alexes C Daquinag, Anna Guzman, Raghav Ramabadran, Chun-Wei Chen, Tianpeng Gu, Sinjini Gupta, Laura Ortinau, Dongsu Park, Aaron R Cox, Rachel E Rau, Sean M Hartig, Mikhail G Kolonin, Margaret A Goodell
Publikováno v:
eLife, Vol 11 (2022)
DNA Methyltransferase 3 A (DNMT3A) is an important facilitator of differentiation of both embryonic and hematopoietic stem cells. Heterozygous germline mutations in DNMT3A lead to Tatton-Brown-Rahman Syndrome (TBRS), characterized by obesity and exce
Externí odkaz:
https://doaj.org/article/50aa572dd7974a318da9ef564b060f60
Autor:
Lindsey S. Treviño, Jianrong Dong, Ahkilesh Kaushal, Tiffany A. Katz, Rahul Kumar Jangid, Matthew J. Robertson, Sandra L. Grimm, Chandra Shekar R. Ambati, Vasanta Putluri, Aaron R. Cox, Kang Ho Kim, Thaddeus D. May, Morgan R. Gallo, David D. Moore, Sean M. Hartig, Charles E. Foulds, Nagireddy Putluri, Cristian Coarfa, Cheryl Lyn Walker
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Early life exposure to environmental stressors, including endocrine disrupting chemicals (EDCs), can impact health later in life. Here, the authors show that neonatal EDC exposure in rats causes epigenetic reprogramming in the liver, which is transcr
Externí odkaz:
https://doaj.org/article/1bd07351812944de819b5ad960475b3b
Autor:
Aaron R. Cox, Natasha Chernis, Kang Ho Kim, Peter M. Masschelin, Pradip K. Saha, Shawn M. Briley, Robert Sharp, Xin Li, Jessica B. Felix, Zheng Sun, David D. Moore, Stephanie A. Pangas, Sean M. Hartig
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101221- (2021)
Objective: White adipose tissue (WAT) expansion regulates energy balance and overall metabolic homeostasis. The absence or loss of WAT occurring through lipodystrophy and lipoatrophy contributes to the development of hepatic steatosis and insulin res
Externí odkaz:
https://doaj.org/article/b4e693534e744d1f9c3d3f322b504585
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
Overnutrition and sedentary activity reinforce the growing trend of worldwide obesity, insulin resistance, and type 2 diabetes. However, we have limited insight into how food intake generates sophisticated metabolic perturbations associated with obes
Externí odkaz:
https://doaj.org/article/9e433f14b3f741188a5c62a5e527d548