Zobrazeno 1 - 10
of 438
pro vyhledávání: '"M. Harnett"'
Autor:
Piaopiao Pan, Yilin Wang, Mukanthu H. Nyirenda, Zainulabedin Saiyed, Elnaz Karimian Azari, Amy Sunderman, Simon Milling, Margaret M. Harnett, Miguel Pineda
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Oral administration of harmless antigens can induce suppression of reactive immune responses, a process that capitalises on the ability of the gastrointestinal tract to tolerate exposure to food and commensal microbiome without triggering in
Externí odkaz:
https://doaj.org/article/640b84d26b4140398d5bb2b0ccf82607
Autor:
Margaret M. Harnett, James Doonan, Anuradha Tarafdar, Miguel A. Pineda, Josephine Duncombe-Moore, Geraldine Buitrago, Piaopiao Pan, Paul A. Hoskisson, Colin Selman, William Harnett
Publikováno v:
Frontiers in Tropical Diseases, Vol 4 (2024)
The parasitic worm-derived immunomodulator, ES-62 rescues defective levels of IL-10-producing regulatory B cells (Bregs) and suppresses chronic Th1/Th17-driven inflammation to protect against joint destruction in the mouse collagen-induced arthritis
Externí odkaz:
https://doaj.org/article/683e487bd806486f86d7ba45a7f58b53
Autor:
Margaret M. Harnett, Felicity E. Lumb, Jenny Crowe, James Doonan, Geraldine Buitrago, Stephanie Brown, Gillian Thom, Amy MacDonald, Colin J. Suckling, Colin Selman, William Harnett
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Mice develop pathology in the lungs as they age and this may be accelerated by a high calorie diet (HCD). ES-62 is a protein secreted by the parasitic worm Acanthocheilonema viteae that is immunomodulatory by virtue of covalently attached phosphorylc
Externí odkaz:
https://doaj.org/article/e3ecfaf3645f4e8596b6d32606f6e458
Autor:
Margaret M. Harnett, James Doonan, Felicity E. Lumb, Jenny Crowe, Roel Olde Damink, Geraldine Buitrago, Josephine Duncombe-Moore, Debbie I. Wilkinson, Colin J. Suckling, Colin Selman, William Harnett
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Despite significant increases in human lifespan over the last century, adoption of high calorie diets (HCD) has driven global increases in type-2 diabetes, obesity and cardiovascular disease, disorders precluding corresponding improvements in healths
Externí odkaz:
https://doaj.org/article/523ab5246f8f4ce380e052b716596cff
Autor:
Mark H. Eckman, Ruth Wise, Anthony C. Leonard, Pete Baker, Rob Ireton, Brett M. Harnett, Estrelita Dixon, Bi Awosika, Chika Ezigbo, Matthew L. Flaherty, Adeboye Adejare, Carol Knochelmann, Rachael Mardis, Sharon Wright, Ashish Gummadi, Richard Becker, Daniel P. Schauer, Alexandru Costea, Dawn Kleindorfer, Heidi Sucharew, Amy Costanzo, Lora Anderson, John Kues
Publikováno v:
American Heart Journal Plus, Vol 18, Iss , Pp 100170- (2022)
Study objective: Atrial fibrillation (AF) is the most common cardiac rhythm disorder, responsible for 15 % of strokes in the United States. Studies continue to document underuse of anticoagulation therapy in minority populations and women. Our object
Externí odkaz:
https://doaj.org/article/1d0b771c73fd4724a68bb2e953036008
Cytohesin-2/ARNO: A Novel Bridge Between Cell Migration and Immunoregulation in Synovial Fibroblasts
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
The guanine nucleotide exchange factor cytohesin-2 (ARNO) is a major activator of the small GTPase ARF6 that has been shown to play an important role(s) in cell adhesion, migration and cytoskeleton reorganization in various cell types and models of d
Externí odkaz:
https://doaj.org/article/53b96b484a8b4c4a8a0b786c355a451a
Autor:
Marlene Corbet, Miguel A. Pineda, Kun Yang, Anuradha Tarafdar, Sarah McGrath, Rinako Nakagawa, Felicity E. Lumb, Colin J. Suckling, William Harnett, Margaret M. Harnett
Publikováno v:
PLoS Pathogens, Vol 17, Iss 11 (2021)
ES-62 is the major secreted protein of the parasitic filarial nematode, Acanthocheilonema viteae. The molecule exists as a large tetramer (MW, ~240kD), which possesses immunomodulatory properties by virtue of multiple phosphorylcholine (PC) moieties
Externí odkaz:
https://doaj.org/article/88da2086d64c47acae3e522a690425a6
Autor:
James Doonan, Anuradha Tarafdar, Miguel A. Pineda, Felicity E. Lumb, Jenny Crowe, Aneesah M. Khan, Paul A. Hoskisson, Margaret M. Harnett, William Harnett
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Gastrointestinal infection with parasitic helminths can protect against mucosal diseases via impacting on the microbiome. Here the authors show that ES-62, a product secreted by a tissue-resident helminth modulates the host gut microbiome to protect
Externí odkaz:
https://doaj.org/article/8765710fbb1b48aea36aa040ff1dbf77
Autor:
Jenny Crowe, Felicity E Lumb, James Doonan, Margaux Broussard, Anuradha Tarafdar, Miguel A Pineda, Carmen Landabaso, Lorna Mulvey, Paul A Hoskisson, Simon A Babayan, Colin Selman, William Harnett, Margaret M Harnett
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008391 (2020)
Improvements in hygiene and health management have driven significant increases in human lifespan over the last 50 years. Frustratingly however, this extension of lifespan has not been matched by equivalent improvements in late-life health, not least
Externí odkaz:
https://doaj.org/article/2771c56a5ed84259b37550f07c50890c
Autor:
T. Kulkarni, J. Santiaguel, R. Aul, M. Harnett, H. Paden, A. Gara, J. Krop, M. Chen, T.M. Maher
Publikováno v:
D21. TRANSLATIONAL COVID-19 STUDIES.