Výsledky vyhledávání

Reduced expression of mitochondrial fumarate hydratase in progressive multiple sclerosis contributes to impaired in vitro mesenchymal stromal cell-mediated neuroprotection

Autor: Neil J Scolding, Anastasia Georgievskaya, Kate J. Heesom, Kelly M Hares, Juliana Redondo, Pamela Sarkar, Steven Bailey, Kevin C Kemp, Claire M Rice

Publikováno v: Sarkar, P, Redondo, J, Hares, K M, Bailey, S, Georgievskaya, A, Heesom, K J, Kemp, K C, Scolding, N J & Rice, C M 2021, ' Reduced expression of mitochondrial fumarate hydratase in progressive multiple sclerosis contributes to impaired in vitro mesenchymal stromal cell-mediated neuroprotection ', Multiple Sclerosis Journal . https://doi.org/10.1177/13524585211060686

Background: Cell-based therapies for multiple sclerosis (MS), including those employing autologous bone marrow-derived mesenchymal stromal cells (MSC) are being examined in clinical trials. However, recent studies have identified abnormalities in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a14b578ae9c3cacd16bd9a36ffc4b3
https://pubmed.ncbi.nlm.nih.gov/34841955

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Akademický článek

Genetic analysis of circadian responses to low frequency electromagnetic fields in Drosophila melanogaster.

Autor: Giorgio Fedele, Mathew D Edwards, Supriya Bhutani, John M Hares, Manuel Murbach, Edward W Green, Stephane Dissel, Michael H Hastings, Ezio Rosato, Charalambos P Kyriacou

Publikováno v: PLoS Genetics, Vol 10, Iss 12, p e1004804 (2014)

The blue-light sensitive photoreceptor cryptochrome (CRY) may act as a magneto-receptor through formation of radical pairs involving a triad of tryptophans. Previous genetic analyses of behavioral responses of Drosophila to electromagnetic fields usi

Externí odkaz: https://doaj.org/article/f5e421b5af99434280b222d247c90bf9

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KIF5A and the contribution of susceptibility genotypes as a predictive biomarker for multiple sclerosis

Autor: Neil J Scolding, Neil Robertson, Emma C. Tallantyre, Alastair Wilkins, Kevin C Kemp, Kelly M Hares, Samantha Loveless, Claire M Rice

Publikováno v: Journal of Neurology
Hares, K, Kemp, K, Loveless, S, Rice, C M, Scolding, N, Tallantyre, E, Robertson, N & Wilkins, A 2021, ' KIF5A and the contribution of susceptibility genotypes as a predictive biomarker for multiple sclerosis ', Journal of Neurology, vol. 268, no. 6, pp. 2175-2184 . https://doi.org/10.1007/s00415-020-10373-w

There is increasing interest in the development of multiple sclerosis (MS) biomarkers that reflect central nervous system tissue injury to determine prognosis. We aimed to assess the prognostic value of kinesin superfamily motor protein KIF5A in MS b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3885e366b3fe590e9f358636ac6acc9b

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shRNA‐mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth

Publikováno v: The Journal of Pathology
Haynes, H R, Scott, H L, Killick-Cole, C L, Shaw, G, Brend, T, Hares, K M, Redondo, J, Kemp, K C, Ballesteros, L S, Herman, A, Cordero-Llana, O, Singleton, W G, Mills, F, Batstone, T, Bulstrode, H, Kauppinen, R A, Wurdak, H, Uney, J B, Short, S C, Wilkins, A & Kurian, K M 2019, ' shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth ', Journal of Pathology, vol. 247, no. 4, pp. 422-434 . https://doi.org/10.1002/path.5201

The overall survival for patients with primary glioblastoma is very poor. Glioblastoma contains a subpopulation of glioma stem cells (GSC) that are responsible for tumour initiation, treatment resistance and recurrence. PPARα is a transcription fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39bf5d26efe7fd0d11f188b4b54bded
http://europepmc.org/articles/PMC6462812

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Bone marrow transplantation stimulates neural repair in Friedreich's ataxia mice

Autor: Juliana Redondo, Harry R Haynes, Neil J Scolding, Alastair Wilkins, Mark A. Pook, Amelia J. Cook, Claire M Rice, Bronwen R Burton, Kevin C Kemp, Kelly M Hares

Publikováno v: Annals of Neurology. 83:779-793

Objective Friedreich's ataxia is an incurable inherited neurological disease caused by frataxin deficiency. Here, we report the neuroreparative effects of myeloablative allogeneic bone marrow transplantation in a humanized murine model of the disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b356dde97f42dc1a4cb795c74596870
https://doi.org/10.1002/ana.25207

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The transcription factor PPARα is overexpressed and is associated with a favourable prognosis in IDH-wildtype primary glioblastoma

Autor: Krishnakumar Garadi, Clare L Killick-Cole, Alastair Wilkins, Juliana Redondo, Paul D. White, Harry R Haynes, Sam Guglani, Kelly M Hares, Kathreena M Kurian, Kevin C Kemp, William G B Singleton, Jonathan R Stevens

Publikováno v: Histopathology. 70:1030-1043

© 2016 John Wiley & Sons Ltd Aims: PPARα agonists are in current clinical use as hypolipidaemic agents and show significant antineoplastic effects in human glioblastoma models. To date however, the expression of PPARα in large-scale glioblastoma d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4375b68b222c536f8de2a3519bb163
https://doi.org/10.1111/his.13142

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Cytokine therapy-mediated neuroprotection in a Friedreich's ataxia mouse model

Autor: Neil J Scolding, Richard Apps, Alastair Wilkins, Kelly M Hares, Nadia L Cerminara, Mark A. Pook, Juliana Redondo, Kevin C Kemp, Bronwen R Burton, Harry R Haynes, Amelia J. Cook

Publikováno v: Annals of Neurology. 81:212-226

Objectives: Friedreich's ataxia is a devastating neurological disease currently lacking any proven treatment. We studied the neuro-protective effects of the cytokines granulocyte-colony stimulating factor and stem cell factor in a humanised murine mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2730d6ee2e25c50e7d35bb4e607c8aa2
https://doi.org/10.1002/ana.24846

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KIF5A and KLC1 expression in Alzheimer’s disease: relationship and genetic influences

Autor: Neil J Scolding, Scott Miners, Kelly M Hares, Alastair Wilkins, Seth Love

Publikováno v: Hares, K M, Miners, S, Scolding, N, Love, S & Wilkins, A 2019, ' KIF5A and KLC1 expression in Alzheimer’s disease: relationship and genetic influences ', AMRC Open Research, vol. 1, 1 . https://doi.org/10.12688/amrcopenres.12861.1

Background: Early disturbances in axonal transport, before the onset of gross neuropathology, occur in a spectrum of neurodegenerative diseases including Alzheimer’s disease. Kinesin superfamily motor proteins (KIFs) are responsible for anterograde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2421ec062855f8691109e9f76e45b332
https://research-information.bris.ac.uk/en/publications/709c1ad3-cad6-4a3e-af2c-40d171cf7d4b

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