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Akademický článek

Plantar pressure distribution profile of type 2 diabetes mellitus with diabetic foot syndrome: A hospital-based observational study

Autor: H. Ya. Korada, E. Arora, Sh. K. Rao, M. Hande, S. Shetty, A. G. Maiya

Publikováno v: Сахарный диабет, Vol 24, Iss 6, Pp 548-552 (2022)

INTRODUCTION: The prevalence of diabetic foot syndrome is increasing in the Indian population. It is a triad of neurological, vascular, and biomechanical changes due to long term diabetes mellitus (DM). Altered plantar pressure distribution is a risk

Externí odkaz: https://doaj.org/article/80ca6207ef5e4ba7a9ff15007f4b61cb

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Akademický článek

The epidemiology and clinical manifestation of neurological melioidosis: A series of 19 cases from Southwest India over 10 years

Autor: I. Halim, T. Shaw, T. A. K. Chaitanya, K. E. Vandana, M. Hande, G. Menon, S. P. Gorthy, C. Mukhopadhyay

Publikováno v: Sri Lankan Journal of Infectious Diseases, Vol 7, Iss 0 (2017)

No abstract available

Externí odkaz: https://doaj.org/article/4df34d2a8e5d43389d10c3662d988143

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Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Publikováno v: Journal of Medicinal Chemistry. 64:14498-14512

Poly-ADP-ribose-polymerase (PARP) inhibitors have achieved regulatory approval in oncology for homologous recombination repair deficient tumors including BRCA mutation. However, some have failed in combination with first-line chemotherapies, usually

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d5da59f02fe0bf1798c2492422c31c3
https://doi.org/10.1021/acs.jmedchem.1c01012

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TB disease patterns by HIV and diabetes status

Autor: S. F. Weber, L. C. Ruby, T. Heller, M. Hande, B. A. Shastry, R. V. Acharya, R. Bhat, S. Shankar, M. Prabhu, A. K. Mohapatra, R. Magazine, R. Kadavigere, C. M. Denkinger, S. Gehring, S. Bélard, K. Saravu

Publikováno v: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 26(8)

BACKGROUND: TB is commonly categorised as pulmonary (PTB) or extrapulmonary TB (EPTB). Knowledge of TB disease patterns (PTB and/or EPTB) and determining risk factors remains limited.METHODS: This was a prospective cohort study using point-of-care ul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ebd12978b121576c548244e5513fc5
https://pubmed.ncbi.nlm.nih.gov/35898145

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Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies

Publikováno v: Journal of Medicinal Chemistry. 63:15564-15590

A CDK9 inhibitor having short target engagement would enable a reduction of Mcl-1 activity, resulting in apoptosis in cancer cells dependent on Mcl-1 for survival. We report the optimization of a series of amidopyridines (from compound 2), focusing o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46785e29e943e36954f937d0f6b5666c
https://doi.org/10.1021/acs.jmedchem.0c01754

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Photoredox and Weak Brønsted Base Dual Catalysis: Alkylation of α-Thio Alkyl Radicals

Autor: Edwin Alfonzo, Sudhir M. Hande

Publikováno v: ACS Catalysis. 10:12590-12595

We report the C–H activation of thioethers to α-thio alkyl radicals and their addition to electron-deficient olefins to afford alkylated products through dual photoredox and weak Bronsted base cata...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a38aecc24e0de571ded2d1a0177eb3a
https://doi.org/10.1021/acscatal.0c03851

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Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement

Publikováno v: Journal of medicinal chemistry. 64(20)

Optimization of a series of azabenzimidazoles identified from screening hit 2 and the information gained from a co-crystal structure of the azabenzimidazole-based lead 6 bound to CDK9 led to the discovery of azaindoles as highly potent and selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640b617db421bd84b5fcddd8d48d0b58
https://pubmed.ncbi.nlm.nih.gov/34647738

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Akademický článek

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Palladium-catalyzed intramolecular carboborylation of 1,3-diene and synthesis of ABCD ring of communesins

Autor: Motoyuki Nakajima, Yoshiji Takemoto, Chihiro Tsukano, Sudhir M. Hande

Publikováno v: Organic & Biomolecular Chemistry. 17(7):1731-1735

A palladium-catalyzed intramolecular carboborylation of 1, 3-diene has been developed for the synthesis of iminoindolines with a quaternary carbon centre. This method was applied to a substrate bearing several functional groups to afford a complex im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdccff768fe8f6c339b8b90a866d4dd
http://hdl.handle.net/2433/243175

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