Zobrazeno 1 - 10
of 188
pro vyhledávání: '"M. Halper"'
Publikováno v:
ACS Synthetic Biology. 9:1563-1571
The synthesis and assembly of long DNA fragments has greatly accelerated synthetic biology and biotechnology research. However, long turnaround times or synthesis failures create unpredictable bottlenecks in the design-build-test-learn cycle. We deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7759fc81ef3caf13c35bc3e90d4101c7
https://doi.org/10.1021/acssynbio.9b00460
https://doi.org/10.1021/acssynbio.9b00460
Autor:
Ayaan Hossain, Sean M. Halper, Grace E. Vezeau, Daniel P. Cetnar, Phillip R. Clauer, Alexander C. Reis, Howard M. Salis
Publikováno v:
Nature Biotechnology. 37:1294-1301
Engineering cellular phenotypes often requires the regulation of many genes. When using CRISPR interference, coexpressing many single-guide RNAs (sgRNAs) triggers genetic instability and phenotype loss, due to the presence of repetitive DNA sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134a5834282915ae8f008928b0f9c326
https://doi.org/10.1038/s41587-019-0286-9
https://doi.org/10.1038/s41587-019-0286-9
The synthesis and assembly of long DNA fragments has greatly accelerated synthetic biology and biotechnology research. However, long turnaround times or synthesis failures create unpredictable bottlenecks in the design-build-test-learn cycle. We deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c303ad253c13b3ba476e881eedd2eecc
https://doi.org/10.1101/2020.06.05.136820
https://doi.org/10.1101/2020.06.05.136820
Autor:
Eric Klavins, Ayaan Hossain, Devin Strickland, Daniel P. Cetnar, Eriberto Lopez, Alexander C. Reis, Howard M. Salis, Sean M. Halper
Publikováno v:
Nature biotechnology. 38(12)
Engineered genetic systems are prone to failure when their genetic parts contain repetitive sequences. Designing many nonrepetitive genetic parts with desired functionalities remains a difficult challenge with high computational complexity. To overco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8dcae595dbea38a3895984e22fb4afb
https://pubmed.ncbi.nlm.nih.gov/32661437
https://pubmed.ncbi.nlm.nih.gov/32661437
Publikováno v:
Methods in Molecular Biology ISBN: 9781493972944
Engineering many-enzyme metabolic pathways suffers from the design curse of dimensionality. There are an astronomical number of synonymous DNA sequence choices, though relatively few will express an evolutionary robust, maximally productive pathway w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75411c992d7039b087a7d02f31a392ca
https://doi.org/10.1007/978-1-4939-7295-1_4
https://doi.org/10.1007/978-1-4939-7295-1_4
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1671
Engineering many-enzyme metabolic pathways suffers from the design curse of dimensionality. There are an astronomical number of synonymous DNA sequence choices, though relatively few will express an evolutionary robust, maximally productive pathway w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3da3d16c359b374e9b42c6f462c33249
https://pubmed.ncbi.nlm.nih.gov/29170952
https://pubmed.ncbi.nlm.nih.gov/29170952
Engineered heterologous metabolic pathways can convert low-cost feedstock into high-value products, though it remains a significant challenge to reliably and efficiently maximize end-product biosynthesis, particularly when many enzymes must be co-exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cef1f09323d9a6f8936ea9d81544048
https://doi.org/10.1101/161372
https://doi.org/10.1101/161372
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Autor:
C.M. Starks, M. Halper
Since 1971 when useful working concepts for the technique of phase-transfer catalysis (PTC) were introduced, the understanding, development, and applica tions of this method for conducting organic reactions has expanded exponentially. PTC has broug
Autor:
P. A. R. Ade, Z. Ahmed, M. Amiri, D. Barkats, R. Basu Thakur, C. A. Bischoff, D. Beck, J. J. Bock, H. Boenish, E. Bullock, V. Buza, J. R. Cheshire IV, J. Connors, J. Cornelison, M. Crumrine, A. Cukierman, E. V. Denison, M. Dierickx, L. Duband, M. Eiben, S. Fatigoni, J. P. Filippini, S. Fliescher, C. Giannakopoulos, N. Goeckner-Wald, D. C. Goldfinger, J. Grayson, P. Grimes, G. Hall, G. Halal, M. Halpern, E. Hand, S. Harrison, S. Henderson, S. R. Hildebrandt, J. Hubmayr, H. Hui, K. D. Irwin, J. Kang, K. S. Karkare, E. Karpel, S. Kefeli, S. A. Kernasovskiy, J. M. Kovac, C. L. Kuo, K. Lau, E. M. Leitch, A. Lennox, K. G. Megerian, L. Minutolo, L. Moncelsi, Y. Nakato, T. Namikawa, H. T. Nguyen, R. O’Brient, R. W. Ogburn IV, S. Palladino, M. Petroff, T. Prouve, C. Pryke, B. Racine, C. D. Reintsema, S. Richter, A. Schillaci, R. Schwarz, B. L. Schmitt, C. D. Sheehy, B. Singari, A. Soliman, T. St. Germaine, B. Steinbach, R. V. Sudiwala, G. P. Teply, K. L. Thompson, J. E. Tolan, C. Tucker, A. D. Turner, C. Umiltà, C. Vergès, A. G. Vieregg, A. Wandui, A. C. Weber, D. V. Wiebe, J. Willmert, C. L. Wong, W. L. K. Wu, H. Yang, K. W. Yoon, E. Young, C. Yu, L. Zeng, C. Zhang, S. Zhang, BICEP/Keck Collaboration
Publikováno v:
The Astrophysical Journal, Vol 949, Iss 2, p 43 (2023)
We present estimates of line-of-sight distortion fields derived from the 95 and 150 GHz data taken by BICEP2, BICEP3, and the Keck Array up to the 2018 observing season, leading to cosmological constraints and a study of instrumental and astrophysica
Externí odkaz:
https://doaj.org/article/1936f647975d4d0384d181a7e1cf562a