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Akademický článek

Sex-specific single cell-level transcriptomic signatures of Rett syndrome disease progression

Autor: Osman Sharifi, Viktoria Haghani, Kari E. Neier, Keith J. Fraga, Ian Korf, Sophia M. Hakam, Gerald Quon, Nelson Johansen, Dag H. Yasui, Janine M. LaSalle

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)

Abstract Dominant X-linked diseases are uncommon due to female X chromosome inactivation (XCI). While random XCI usually protects females against X-linked mutations, Rett syndrome (RTT) is a female neurodevelopmental disorder caused by heterozygous M

Externí odkaz: https://doaj.org/article/27f2deea1c084c859913e45acdf66dda

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Akademický článek

567 Multigenerational impacts on DNA methylation signatures in autism spectrum disorder

Autor: George Eusebio Kuodza, Ray Kawai, Yunin J.L. Rodriguez, Julia S. Mouat, Sophia M. Hakam, Timothy N. Sullivan, Cole R. Torvick, Deborah Bennett, Irva Hertz-Picciotto, Janine M. LaSalle

Publikováno v: Journal of Clinical and Translational Science, Vol 8, Pp 169-169 (2024)

OBJECTIVES/GOALS: to investigate the potential impact of grandparental factors and multigenerational epigenetic inheritance on the development of ASD METHODS/STUDY POPULATION: Our study recruited participants from the CHARGE (Child Autism Risks from

Externí odkaz: https://doaj.org/article/5602fbb4f9dd4c11bec540ab8b0e27eb

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Akademický článek

Sex disparate gut microbiome and metabolome perturbations precede disease progression in a mouse model of Rett syndrome

Autor: Kari Neier, Tianna E. Grant, Rebecca L. Palmer, Demario Chappell, Sophia M. Hakam, Kendra M. Yasui, Matt Rolston, Matthew L. Settles, Samuel S. Hunter, Abdullah Madany, Paul Ashwood, Blythe Durbin-Johnson, Janine M. LaSalle, Dag H. Yasui

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)

Using a mouse model for Rett syndrome (RTT), Neier et al analyze gut microbiome and metabolome profiles during disease progression. They show that pathophysiology and progression of RTT is different in females than in males and suggest that changes i

Externí odkaz: https://doaj.org/article/c1d9cbe8712d4cf99e5108bdab6417d3

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Effect of two fascial incision options for access to the temporomandibular joint on facial nerve function: objective investigation

Autor: S.A. Elsayed, S. Hassan, M. Hakam, S. Mekhemer, F. Mobarak

Publikováno v: International Journal of Oral and Maxillofacial Surgery. 51:933-941

This study was performed to compare the effects on facial nerve (FN) function of the deep supra-temporalis muscle subfascial approach (DSFA) and traditional fascial approach (TFA) for access to the temporomandibular joint (TMJ), via qualitative and q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddca58f3daeb0558b65c0be11c309aff
https://doi.org/10.1016/j.ijom.2021.12.010

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Akademický článek

Gustatory dysfunction in relation to circumvallate papilla’s taste buds structure upon unilateral maxillary molar extraction in Wistar rats: an in vivo study [version 1; peer review: 2 approved]

Autor: Sana Mostafa, Heba M. Hakam, Amal El-motayam

Publikováno v: F1000Research, Vol 8 (2019)

Background: The interaction between taste sensation and dentoalveolar innervation is still under research. teeth loss can alter taste thresholds in humans, but the underlying mechanisms are still obscure. This study investigated the effect of unilate

Externí odkaz: https://doaj.org/article/5d22f0541e264c79b082d3751013162f

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Akademický článek

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Effect of Absorbable Gelatin Sponge on osteogenic activity in Atrophied Posterior Maxilla. (Histopathological and gene expression studies)

Autor: Heba M. Hakam, Hamida Mohammad Refaee, Reem Hassan Saad

Publikováno v: Egyptian Dental Journal. 66:1055-1062

Objective: Clinical trials studied different materials and techniques for atrophied ridge augmentation regarding function implant stability and bone level. Microanalysis of the bone reaction to augmentation is still under investigation. The present s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82eefde1678293cb2b049f23246ed3b8
https://doi.org/10.21608/edj.2020.24057.1022

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EFFECT OF DEXAMETHASONE INFILTRATION ON PERIODONTAL LIGAMENT AFTER EXPERIMENTAL MOLAR LUXATION IN RATS

Autor: Heba M. Hakam

Publikováno v: Egyptian Dental Journal. 66:301-312

Aim of the study: Dexamethasone is a popular corticosteroid in dental practice. Submucosal infiltration of dexamethasone proved to be effective to relief post-operative symptoms in different clinical and research application. This study was conducted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::591fda65965c040b91d36247dc314a9f
https://doi.org/10.21608/edj.2020.77548

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